Vitamin and mineral deficiency in children newly diagnosed with celiac disease

Objective & Hypothesis:Background/aim: To establish the frequency of vitamin and mineral deficiency in children newly diagnosed with celiac disease.

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Key Findings & Data:Materials and methods: The files of patients diagnosed with celiac disease in our Pediatric Gastroenterology Clinic from June 2008 to June 2013 were reviewed retrospectively.

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Conclusion & Impact:Therefore, serum vitamin D, zinc, and iron levels should be checked in all children diagnosed with celiac disease.

🔬Design:Review & Systematic Survey

📍Scope:2008 Verileri

⚙️Variables:Celiac · iron · vitamin A

Abstract

Background/aim: To establish the frequency of vitamin and mineral deficiency in children newly diagnosed with celiac disease. Materials and methods: The files of patients diagnosed with celiac disease in our Pediatric Gastroenterology Clinic from June 2008 to June 2013 were reviewed retrospectively. Results: A total of 52 pediatric patients diagnosed with celiac disease via serology and duodenal biopsy and who fulfilled the study criteria were enrolled in the study. The mean diagnosis age of the patients was 8.5 ± 3.9 years and 33 (63.5%) of the patients were female. Vitamin D, vitamin A, vitamin E, zinc, and iron deficiencies were determined in 27 (51.9%), 4 (7.7%), 7 (13.5%), 35 (67.3%), and 18 (34.6%) patients, respectively, at the time of diagnosis. Vitamin D deficiency was observed more frequently in patients with growth retardation at the time of application (P = 0.02). Conclusion: Vitamin D, zinc, and iron deficiency are frequently observed in pediatric patients with celiac disease at the time of diagnosis. Therefore, serum vitamin D, zinc, and iron levels should be checked in all children diagnosed with celiac disease.

Özet

Background/aim: To establish the frequency of vitamin and mineral deficiency in children newly diagnosed with celiac disease. Materials and methods: The files of patients diagnosed with celiac disease in our Pediatric Gastroenterology Clinic from June 2008 to June 2013 were reviewed retrospectively. Results: A total of 52 pediatric patients diagnosed with celiac disease via serology and duodenal biopsy and who fulfilled the study criteria were enrolled in the study. The mean diagnosis age of the patients was 8.5 ± 3.9 years and 33 (63.5%) of the patients were female. Vitamin D, vitamin A, vitamin E, zinc, and iron deficiencies were determined in 27 (51.9%), 4 (7.7%), 7 (13.5%), 35 (67.3%), and 18 (34.6%) patients, respectively, at the time of diagnosis. Vitamin D deficiency was observed more frequently in patients with growth retardation at the time of application (P = 0.02). Conclusion: Vitamin D, zinc, and iron deficiency are frequently observed in pediatric patients with celiac disease at the time of diagnosis. Therefore, serum vitamin D, zinc, and iron levels should be checked in all children diagnosed with celiac disease.

Keywords

Celiac iron vitamin A vitamin D vitamin E zinc

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Cite This Article

TOPAL, E., ÇATAL, F., ACAR, N. Y., ERMİŞTEKİN, H., SİNANOĞLU, M. S., KARABİBER, H., SELİMOĞLU, M. A. (2015). Vitamin and mineral deficiency in children newly diagnosed with celiac disease. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 4, 833–836. https://ajindex.com/articles/186188

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References (2)

Setty M, Hormaza L, Guandalini S. Celiac disease: risk assessment, diagnosis, and monitoring. Mol Diagn Ther 2008; 12: 289‒298. Farrel RJ, Kelly CP. Celiac sprue and refractory sprue. In: Feldman M, editor. Sleisenger & Fordtran’s Gastrointestinal and Liver Disease Pathophysiology/Diagnosis/Management. 7th ed. Philadelphia, PA, USA: WB Saunders; 2002. pp. 1818‒1841. Farrell RJ, Kelly CP. Celiac sprue. N Engl J Med 2002; 346: 180‒188. 4. Unsworth DJ, Lock FJ, Harvey RF. Iron deficiency anaemia in premenopausal women. Lancet 1999; 353: 1100. Bottaro G, Cataldo F, Rotolo N, Spina M, Corazza GR. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. Am J Gastroenterol 1999; 94: 691‒696. Kolho KL, Farkkila MA, Savilahti E. Undiagnosed coeliac disease is common in Finnish adults. Scand J Gastroenterol 1998; 33: 1280‒1283. 7. Hin H, Bird G, Fisher P, Mahy N, Jewell D. Coeliac disease in primary care: case finding study. BMJ 1999; 318: 164‒167. Lo W, Sano K, Lebwohl B, Diamond B, Green PH. Changing presentation of adult celiac disease. Dig Dis Sci 2003; 48: 395‒398. Çatal F, Topal E, Ermiştekin H, Yıldırım N, Sinanoğlu MS, Karabiber H, SelimoğluMA. Hematologic manifestations of pediatric celiac disease at the time of diagnosis and efficiency of gluten-free diet. Turk J Med Sci 2015; 45: 663-667
Rastogi A, Bhadada SK, Bhansali A, Kochhar R, Santosh R. Celiac disease: a missed cause of metabolic bone disease. Indian J Endocrinol Metab 2012; 16: 780‒785. Wierdsma NJ, van Bokhorst-de van der Schueren MA, Berkenpas M, Mulder CJ, van Bodegraven AA. Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients. Nutrients 2013; 5: 3975‒3992. Husby S, Koletzko S, Korponay-Szabo IR, Shamir R, Troncone R, Giersiepen K, Branski D, Catassi C, Lelgeman M, Mäki M et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012; 54: 136‒160. Oberhuber G. Histopathology of celiac disease. Biomed Pharmacother 2000; 54: 368‒372. Tavakkoli A, DiGiacomo D, Green PH, Lebwohl B. Vitamin D status and concomitant autoimmunity in celiac disease. J Clin Gastroenterol 2013; 47: 515‒519. Pınar AA. Çocukluk çağı laboratuar referans değerleri. In: Hasanoğlu E, Düşünsel R, Bideci A, editors. Temel Pediatri. 1st ed. Ankara, Turkey: Güneş Tıp Kitabevi; 2010. pp. 1755‒1783 (in Turkish). McGough N, Cummings JH. Coeliac disea