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Journals / Turkish Journal of Medical Sciences / 2015 / Cilt: 45 - Sayı: 4

A case-control study: evaluation of vitamin D metabolism in patients with vitiligo

ZENNURE TAKCI
ÖZLEM TEKİN
Derun Taner ERTUĞRUL
Ayşe Serap KARADAĞ
Kadir Okhan AKIN
Pages
837–841
Publication Date
2015-08-13
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies are needed to understand the role of vitamin D metabolism in the pathogenesis of vitiligo.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aim: Reduced vitamin D is considered as one of the environmental factors that can increase the prevalence of certain autoimmune diseases.
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Key Findings & Data:Materials and methods: A prospective case-control study was conducted on 44 consecutive patients with vitiligo vulgaris and 43 healthy controls.
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Conclusion & Impact:Further studies are needed to understand the role of vitamin D metabolism in the pathogenesis of vitiligo.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Vitiligo · 25-hydroxyvitamin D · vitamin D metabolism

Abstract

Background/aim: Reduced vitamin D is considered as one of the environmental factors that can increase the prevalence of certain autoimmune diseases. This study aimed to assess vitamin D metabolism in patients with vitiligo. Materials and methods: A prospective case-control study was conducted on 44 consecutive patients with vitiligo vulgaris and 43 healthy controls. Their plasma 25-hydroxyvitamin D (25(OH)D), parathormone (PTH), calcium, magnesium, and phosphate levels were measured. Results: There was no significant difference in the mean age, sex and Fitzpatrick skin phototype between the patient and control groups (P > 0.05). The plasma levels of 25(OH)D and calcium were signi?cantly decreased (P = 0.002, P < 0.0001, respectively) and PTH and magnesium levels were significantly increased in patients with vitiligo (P < 0.0001, P < 0.0001, respectively). The advancement of age (P = 0.03, R = -0.18) and comorbid autoimmune illnesses (P = 0.04) were found to be significantly associated with lower 25(OH)D levels. Conclusion: There is a universal lack of 25(OH)D in the Turkish population. Screening for vitamin D may be a tool for the presence of comorbid autoimmune diseases. Further studies are needed to understand the role of vitamin D metabolism in the pathogenesis of vitiligo.

Özet

Background/aim: Reduced vitamin D is considered as one of the environmental factors that can increase the prevalence of certain autoimmune diseases. This study aimed to assess vitamin D metabolism in patients with vitiligo. Materials and methods: A prospective case-control study was conducted on 44 consecutive patients with vitiligo vulgaris and 43 healthy controls. Their plasma 25-hydroxyvitamin D (25(OH)D), parathormone (PTH), calcium, magnesium, and phosphate levels were measured. Results: There was no significant difference in the mean age, sex and Fitzpatrick skin phototype between the patient and control groups (P > 0.05). The plasma levels of 25(OH)D and calcium were signi?cantly decreased (P = 0.002, P < 0.0001, respectively) and PTH and magnesium levels were significantly increased in patients with vitiligo (P < 0.0001, P < 0.0001, respectively). The advancement of age (P = 0.03, R = -0.18) and comorbid autoimmune illnesses (P = 0.04) were found to be significantly associated with lower 25(OH)D levels. Conclusion: There is a universal lack of 25(OH)D in the Turkish population. Screening for vitamin D may be a tool for the presence of comorbid autoimmune diseases. Further studies are needed to understand the role of vitamin D metabolism in the pathogenesis of vitiligo.

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Cite This Article

TAKCI, Z., TEKİN, Ö., ERTUĞRUL, D. T., KARADAĞ, A. S., AKIN, K. O. (2015). A case-control study: evaluation of vitamin D metabolism in patients with vitiligo. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 4, 837–841. https://ajindex.com/articles/186183

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