A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions.
📊
Key Findings & Data:Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions.
💡
Conclusion & Impact:A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Deprotection · ketal · IBX
Abstract
Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions. A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.
Özet
Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions. A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.
RAZA, A. R. (2009). A Mild Method for the Cleavage of Ketals Using IBX. Turkish Journal of Chemistry, Cilt: 33 - Sayı: 2, 209–214. https://ajindex.com/articles/184957