Silica phosphoric acid could be reused for 3 times without visible loss of activity.
📌 3 Key Takeaways
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Objective & Hypothesis:Reaction of sulfonamides with carboxylic acid anhydrides and chlorides in the presence of silica phosphoric acid provided N-acyl sulfonamides in good to high yields.
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Key Findings & Data:All reactions were performed under mild conditions in solvent-free and heterogeneous systems and the products were obtained in high purity after a simple work-up.
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Conclusion & Impact:Silica phosphoric acid could be reused for 3 times without visible loss of activity.
Reaction of sulfonamides with carboxylic acid anhydrides and chlorides in the presence of silica phosphoric acid provided N-acyl sulfonamides in good to high yields. All reactions were performed under mild conditions in solvent-free and heterogeneous systems and the products were obtained in high purity after a simple work-up. Silica phosphoric acid could be reused for 3 times without visible loss of activity.
Özet
Reaction of sulfonamides with carboxylic acid anhydrides and chlorides in the presence of silica phosphoric acid provided N-acyl sulfonamides in good to high yields. All reactions were performed under mild conditions in solvent-free and heterogeneous systems and the products were obtained in high purity after a simple work-up. Silica phosphoric acid could be reused for 3 times without visible loss of activity.
MASSAH, A. R., DABAGH, M., AFSHAR, M., MOMENI, A. R. (2007). A Convenient and Efficient Synthesis of N-Acylsulfonamides in the Presence of Silica Phosphoric Acid under Heterogeneous and Solvent-Free Conditions. Turkish Journal of Chemistry, Cilt: 31 - Sayı: 6, 611–616. https://ajindex.com/articles/184942