Umpolung strategy: advances in catalytic C-C bond formations

Key Findings & Data:In the context of umpolung, the studies are evaluated under 3 main titles: enzyme, N-heterocyclic carbene, and cyanide ion catalyzed reactions.

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Conclusion & Impact:In particular, enzyme and NHC catalyzed reactions mainly involve asymmetric applications.

🔬Design:Review & Systematic Survey

📍Scope:Comprehensive Sample

⚙️Variables:Umpolung · thiamine pyrophosphate (TPP) · N-heterocyclic carbene

Abstract

This mini-review examines the recent advances in umpolung strategy, devised originally by Corey and Seebach. Although numerous stoichiometric variants have been published to date, this article covers just the catalytic C-C bond forming reactions due to their major benefits such as atom economy, less pollution, and workable simplicity. In the context of umpolung, the studies are evaluated under 3 main titles: enzyme, N-heterocyclic carbene, and cyanide ion catalyzed reactions. In particular, enzyme and NHC catalyzed reactions mainly involve asymmetric applications.

Özet

This mini-review examines the recent advances in umpolung strategy, devised originally by Corey and Seebach. Although numerous stoichiometric variants have been published to date, this article covers just the catalytic C-C bond forming reactions due to their major benefits such as atom economy, less pollution, and workable simplicity. In the context of umpolung, the studies are evaluated under 3 main titles: enzyme, N-heterocyclic carbene, and cyanide ion catalyzed reactions. In particular, enzyme and NHC catalyzed reactions mainly involve asymmetric applications.

Keywords

Umpolung thiamine pyrophosphate (TPP)N-heterocyclic carbene asymmetric synthesis

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Cite This Article

EYMUR, S., GÖLLÜ, M., TANYELİ, C. (2013). Umpolung strategy: advances in catalytic C-C bond formations. Turkish Journal of Chemistry, Cilt: 37 - Sayı: 4, 586–609. https://ajindex.com/articles/184761

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