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Journals / Turkish Journal of Chemistry / 2018 / Cilt: 42 - Sayı: 5

A novel core-shell-based chromatographic method supported by ratio derivative spectrophotometry for the simultaneous determination of perindopril, indapamide, and amlodipine ternary mixtures

Leyla KARADURMUŞ
Mehmet GÜMÜŞTAŞ
Sevinç KURBANOĞLU
Bengi USLU
Sibel A. ÖZKAN
Pages
1408–1419
Publication Date
2018-10-11
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The proposed methods were successfully applied for the simultaneous assay of the drug combination in pharmaceutical dosage forms and the methods were compared to each other in terms of Student t and F tests for the comparison of their accuracy and precision parameters.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this work, ratio spectra of the first derivative spectrophotometric and liquid chromatographic methods have been described for the first time for the simultaneous determination of perindopril (PER), indapamide (IND), and amlodipine (AML) in dosage forms.
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Key Findings & Data:Optimum chromatographic separation was achieved using a Kinetex C18 column (150 ×× 4.6 mm I.D. 5 μμm) at a flow rate of 1.5 mL min−1−1.
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Conclusion & Impact:The proposed methods were successfully applied for the simultaneous assay of the drug combination in pharmaceutical dosage forms and the methods were compared to each other in terms of Student t and F tests for the comparison of their accuracy and precision parameters.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Amlodipine · indapamide · perindopril

Abstract

In this work, ratio spectra of the first derivative spectrophotometric and liquid chromatographic methods have been described for the first time for the simultaneous determination of perindopril (PER), indapamide (IND), and amlodipine (AML) in dosage forms. For chromatographic separations several mobile phase compositions were tested for efficient separation with the use of a new column technology related to superficially porous particles. Optimum chromatographic separation was achieved using a Kinetex C18 column (150 ×× 4.6 mm I.D. 5 μμm) at a flow rate of 1.5 mL min−1−1. The separation was carried out at 30 ∘∘C and the diode array detector was adjusted to 215 nm. As a comparison, a spectrophotometric method depending on the first derivative of the ratio spectra was developed. The first derivative of the ratio amplitudes at 227.2 nm for PER, 269.4 nm for AML, 292.0 nm for IND were selected. The proposed methods were successfully applied for the simultaneous assay of the drug combination in pharmaceutical dosage forms and the methods were compared to each other in terms of Student t and F tests for the comparison of their accuracy and precision parameters.

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Cite This Article

KARADURMUŞ, L., GÜMÜŞTAŞ, M., KURBANOĞLU, S., USLU, B., ÖZKAN, S. A. (2018). A novel core-shell-based chromatographic method supported by ratio derivative spectrophotometry for the simultaneous determination of perindopril, indapamide, and amlodipine ternary mixtures. Turkish Journal of Chemistry, Cilt: 42 - Sayı: 5, 1408–1419. https://ajindex.com/articles/184279

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