SavedAdd your journal

Journals / Turkish Journal of Biology / 2011 / Cilt: 35 - Sayı: 3

Determining mitotic index in peripheral lymphocytes of welders exposed to metal arc welding fumes

Ceylan ALAKOÇ
Halil Erhan EROĞLU
Pages
325–330
Publication Date
2011-03-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to the results, mitotic index (2.278 ± 1.325) of the welders was higher than that of those non-exposed (0.956 ± 0.616) (P < 0.01).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Gas metal arc welding is a widely used method in a lot of industrial areas as it is cheap and produces high quality results.
📊
Key Findings & Data:In the present study, peripheral blood lymphocytes of 23 welders and 25 non-exposed subjects were monitored for cytotoxicity.
💡
Conclusion & Impact:According to the results, mitotic index (2.278 ± 1.325) of the welders was higher than that of those non-exposed (0.956 ± 0.616) (P < 0.01).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Gas metal arc welding · mitotic index · welder

Abstract

Gas metal arc welding is a widely used method in a lot of industrial areas as it is cheap and produces high quality results. In the present study, peripheral blood lymphocytes of 23 welders and 25 non-exposed subjects were monitored for cytotoxicity. Information regarding the subjects' ages, smoking habits, alcohol consumption, duration of exposure, and medicine usage was recorded. According to the results, mitotic index (2.278 ± 1.325) of the welders was higher than that of those non-exposed (0.956 ± 0.616) (P < 0.01). There was no significant difference between mitotic index rates of smoking and non-smoking subjects. In contrast, there were significant differences between non-exposed subjects and welders for both smoking and non-smoking (P < 0.05). It was found that as the time of exposure to welding fumes increased so did the mitotic index rates (P < 0.05). Both a positive correlation in welders and a negative correlation in non-exposed subjects were observed between mitotic index frequency and age. In the light of the results obtained, it is advised that welders who work with gas metal arc welding be instructed and necessary protective measures be taken because of the risk caused by metal arc welding fumes.

Özet

Gas metal arc welding is a widely used method in a lot of industrial areas as it is cheap and produces high quality results. In the present study, peripheral blood lymphocytes of 23 welders and 25 non-exposed subjects were monitored for cytotoxicity. Information regarding the subjects' ages, smoking habits, alcohol consumption, duration of exposure, and medicine usage was recorded. According to the results, mitotic index (2.278 ± 1.325) of the welders was higher than that of those non-exposed (0.956 ± 0.616) (P < 0.01). There was no significant difference between mitotic index rates of smoking and non-smoking subjects. In contrast, there were significant differences between non-exposed subjects and welders for both smoking and non-smoking (P < 0.05). It was found that as the time of exposure to welding fumes increased so did the mitotic index rates (P < 0.05). Both a positive correlation in welders and a negative correlation in non-exposed subjects were observed between mitotic index frequency and age. In the light of the results obtained, it is advised that welders who work with gas metal arc welding be instructed and necessary protective measures be taken because of the risk caused by metal arc welding fumes.

🔖

Cite This Article

ALAKOÇ, C., EROĞLU, H. E. (2011). Determining mitotic index in peripheral lymphocytes of welders exposed to metal arc welding fumes. Turkish Journal of Biology, Cilt: 35 - Sayı: 3, 325–330. https://ajindex.com/articles/182019

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. IARC. Monographs on the evaluation of the carcinogenic risk of chemicals to humans: chromium, nickel and welding, Vol. 49. International Agency for Research on Cancer, Lyon; 1990: pp. 447-525.
  2. McNeilly JD, Heal MR, Beverland IJ et al. Soluble transition metals cause the pro-infl ammatory eff ects of welding fumes in vitro. Toxicol Appl Pharmacol 196: 95-107, 2004. Morgan WKC. On welding, wheezing, and whimsy. Am Ind Hyg Assoc J 50: 59-69, 1989.
  3. Tuschl H, Weber E, Kovac R. Investigations on immune parameters in welders. J Appl Toxicol 17: 377-383, 1997.
  4. Buerke U, Schneider J, Rosler J et al. Interstitial pulmonary fi brosis aft er severe exposure to welding fumes. Am J Ind Med 41: 259-268, 2002.
  5. Funahashi A, Schlueter DP, Pintar K et al. Welder’s pneumoconiosis: tissue elemental microanalysis by energy dispersive X-ray analysis. Br J Ind Med 45: 14-18, 1988.
  6. Martin CJ, Guidotti TL, Langaård S. Respiratory hazards of welding. Clin Pulm Med 4: 194-204, 1997.
  7. Lee CR, Ryu CI, Lee JH et al. Nasal septum perforation of welders. Korean J Occup Med 10: 404-411, 1998.
  8. Benova D, Hadjidekova V, Hristova R et al. Cytogenetic eff ects of hexavalent chromium in Bulgarian chromium platers. Mutat Res 514: 29-38, 2002.
  9. Huvinen M, Makitie A, Jarventaus H et al. Nasal cells micronuclei, cytology and clinical symptoms in stainless steel production workers exposed to chromium. Mutagenesis 17: 425-429, 2002.
  10. Blasiak J, Arabski M, Pertynski T et al. DNA damage in human colonic mucosa cells evoked by nickel and protective action of quercetin-involvement of free radicals. Cell Biol Toxicol 18: 279-288, 2002.
  11. Kiilunen M, Utela J, Rantanen T et al. Exposure to soluble nickel in electrolytic nickel refi ning. Ann Occup Hyg 41: 167- 188, 1997.
  12. Holland NT, Duramad P, Rothman N et al. Micronucleus frequency and proliferation in human lymphocytes aft er exposure to herbicide 2,4-dichlorophenoxyacetic acid in vitro and in vivo. Mutat Res 521: 165-178, 2002. Walker PMB. Th e mitotic index and interphase processes. Biophysics Research Unit. King’s College, London; 1952: pp. 8-15.
  13. Knudsen LE, Boisen T, Christensen JM et al. Biomonitoring of genotoxic exposure among stainless steel welders. Mutat Res 279: 129-143, 1992. Jelmert Ø, Hansteen IL, Langård S. Chromosome damage in lymphocytes of stainless steel welders related to past and current exposure to manual metal arc welding fumes. Mutat Res 320: 223-233, 1994. Jelmert Ø, Hansteen IL, Langård S. Cytogenetic studies of stainless steel welders