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Journals / Turkish Journal of Biology / 2008 / Cilt: 32 - Sayı: 1

Antipyretic Activity of Peperomia pellucida Leaves in Rabbit

Alam KHAN
Moizur RAHMAN
Shariful ISLAM
Pages
37–41
Publication Date
2008-01-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This antipyretic effect has been compared with antipyretic effect of standard aspirin and the solvent used.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Antipyretic effects of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the leaves of Peperomia pellucida (Linn.) HBK (Fam.
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Key Findings & Data:Intraperitoneal administration of boiled milk at a dose of 0.5 ml/kg body weight in albino rabbit leads to pyrexia.
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Conclusion & Impact:This antipyretic effect has been compared with antipyretic effect of standard aspirin and the solvent used.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Peperomia pellucida · leaves · antipyretic

Abstract

Antipyretic effects of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the leaves of Peperomia pellucida (Linn.) HBK (Fam. Piperaceae) were investigated. Intraperitoneal administration of boiled milk at a dose of 0.5 ml/kg body weight in albino rabbit leads to pyrexia. Intraperitoneal (i.p.) administration of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the leaves of P. pellucida at a dose of 80 mg/kg body weight significantly reduced the elevated body temperature of rabbit. This antipyretic effect has been compared with antipyretic effect of standard aspirin and the solvent used.

Özet

Antipyretic effects of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the leaves of Peperomia pellucida (Linn.) HBK (Fam. Piperaceae) were investigated. Intraperitoneal administration of boiled milk at a dose of 0.5 ml/kg body weight in albino rabbit leads to pyrexia. Intraperitoneal (i.p.) administration of petroleum ether and ethyl acetate soluble fractions of ethanol extract of the leaves of P. pellucida at a dose of 80 mg/kg body weight significantly reduced the elevated body temperature of rabbit. This antipyretic effect has been compared with antipyretic effect of standard aspirin and the solvent used.

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Cite This Article

KHAN, A., RAHMAN, M., ISLAM, S. (2008). Antipyretic Activity of Peperomia pellucida Leaves in Rabbit. Turkish Journal of Biology, Cilt: 32 - Sayı: 1, 37–41. https://ajindex.com/articles/181898

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References (9)

  1. Ragasa CY, Dumato M, Rideout JA. Antifungal compounds from Peperomia pellucida. ACGC Chem Res Commun 7: 54-61, 1998. 9. Xu S, Li N, Ning MM et al. Bioactive compounds from Peperomia pellucida. J Nat Prod 69: 247-250, 2006.
  2. Chattopadhyay D, Arunachalam G, Ghosh L et al. Antipyretic activity of Alstonia macrophylla Wall ex A. DC: An ethnomedicine of Andaman Islands. J Pharm Pharmaceutical Sci 8: 558-564, 2005.
  3. Spacer CB, Breder CD. The neurologic basis of fever. N Engl J Med 330: 1880-1886, 1994.
  4. Veugelers PJ, Kaldor JM, Strathdee SA et al. Incidence and prognostic significance of symptomatic primary human immunodeficiency virus type 1 infection in homosexual men. J Infect Dis 176: 112-117, 1997.
  5. Cheng L, Ming-liang H, Lars B et al. Is COX-2 a perpetrator or a protector? Selective COX-2 inhibitors remain controversial. Acta Pharmacologica Sinica 26: 926-933, 2005.
  6. Bhal BS, Bhal A. A text book of Organic Chemistry. 13thed., Schand and Company Ltd. India; 1992: pp. 5-6, 11-12, 14. Jeffery GH, Bassett J, Mendham J et al. Vogel’s Textbook of Quantitative Chemical Analysis. 5thed., Longman Group UK Ltd. England; 2000: p. 161. Alam MK. Pharmacological Profile of CNS Receptors for Active Medicinal Plant of Bangladesh. M. Pharm Thesis, Jahangirnagar University, Bangladesh; 1997: pp. 91-101. Grover JK. Experiments in Pharmacy and Pharmacology. 1sted., Vol. 2, CBS Publisher and Distributor. Shahdara Delhi, India; 1990: p. 155. Nammi S, Boini MK, Lodagala SD et al. The juice of fresh leaves of Catharanthus roseus Linn. reduce blood glucose in normal and alloxan diabetic rabbits. BMC Complementary and Alternative Medicine 3: 4-7, 2003. Brithsh Veterinary Association Animal Welfare Foundation (BVAAWF), Fund for replacement of Animals in Medical Experiments (FRAME), Royal Society for the Prevention of Cruelty to Animal (RSPCA), Universities Federation for Animal Welfare (UFAW) Joint working group on Refinement. Refinement in rabbit husbandry. Lab Anim 27: 301-329, 1993.
  7. Mutalik S, Paridhavi K, Rao CM et al. Antipyretic and analgesic effect of leaves of Solanum Melongena Linn. in rodents. Indian J Pharmacol 35: 312-315, 2003.
  8. Taran SG, Bezuglyi PA, Depeshko IT et al. Synthesis, structure, and biological activity of α-acyl derivatives of N-R- oxamoylphenylhydrazines. Pharm Chem J 18:17-20, 1984.
  9. Kinsella JE, Lokesh B, Broughton S et al. Dietary polyunsaturated fatty acid and eicosanoids; Potential effects on the modulation of inflammatory and immuned cells: an overview. Nut