The application of mesenchymal progenitor stem cells for the reduction of oxidative stress in animals

Abstract

Oxidative stress is the primary cause of lowering of the body's immune status. It arises as a result of intense metabolic processes in humans and animals that involve a decrease in antioxidant enzymes activity at the expense of increased production of free radicals and reactive oxygen species (ROS). Consequently, this leads to oxidation of lipids, proteins, DNA, and RNA, causing cell proliferation reduction, faster cell aging, and subsequent degradation. Currently, there is a search for methods to maintain an oxidation-antioxidant balance. The results of many authors' research point to the effectiveness of the use of mesenchymal stem cells (MSCs) in the treatment of various clinical disorders. Numerous studies indicate that, compared to other cells, MSCs have ability to regulate cell adhesion molecules. They also have specific immunogenic and immunosuppressive properties that determine their application in clinical research and regenerative medicine.