Effects of a Western-style diet high in cholesterol and saturated faton the rabbit exocrine pancreas

These results suggest a homeostatic adaptation of the pancreas to an atherogenic diet and a greater resistance to the development of lesions than exists in other organs.

📌 3 Key Takeaways

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Objective & Hypothesis:Abstract: Despite the well-known cardiovascular effects of an atherogenic diet, there are no data relating to its effect on the exocrine pancreas.

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Key Findings & Data:Twelve New Zealand rabbits were randomised to one of two dietary groups, control group (C) and hypercholesterolemic (HCHOL), that were fed for 50 days with a standard chow or a diet containing 95.7% standard chow, 3% lard, and 1.3% cholesterol, respectively.

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Conclusion & Impact:These results suggest a homeostatic adaptation of the pancreas to an atherogenic diet and a greater resistance to the development of lesions than exists in other organs.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Western diet · exocrine pancreas · membrane fatty acids

Abstract

Abstract: Despite the well-known cardiovascular effects of an atherogenic diet, there are no data relating to its effect on the exocrine pancreas. Therefore, the aim of this study was to investigate the consequences of this eating pattern on the exocrine pancreas. Twelve New Zealand rabbits were randomised to one of two dietary groups, control group (C) and hypercholesterolemic (HCHOL), that were fed for 50 days with a standard chow or a diet containing 95.7% standard chow, 3% lard, and 1.3% cholesterol, respectively. Pancreatic enzyme activity, cholesterol, and membrane fatty acids were determined by established methods. The activity of pancreatic lipase (6.46 ± 0.948 vs. 1.40 ± 0.460; P < 0.05), colipase (8.93 ± 2.138 vs. 2.36 ± 0.512; P < 0.05), and chymotrypsin (18.54 ± 3.125 vs. 9.69 ± 1.363; P < 0.05) were greater in group HCHOL than in group C. The HCHOL diet increased monounsaturated fatty acids and decreased saturated fatty acids in pancreatic plasma membranes compared with the standard chow. These results suggest a homeostatic adaptation of the pancreas to an atherogenic diet and a greater resistance to the development of lesions than exists in other organs. Further studies are needed, given the lack of research on this issue.

Özet

Abstract: Despite the well-known cardiovascular effects of an atherogenic diet, there are no data relating to its effect on the exocrine pancreas. Therefore, the aim of this study was to investigate the consequences of this eating pattern on the exocrine pancreas. Twelve New Zealand rabbits were randomised to one of two dietary groups, control group (C) and hypercholesterolemic (HCHOL), that were fed for 50 days with a standard chow or a diet containing 95.7% standard chow, 3% lard, and 1.3% cholesterol, respectively. Pancreatic enzyme activity, cholesterol, and membrane fatty acids were determined by established methods. The activity of pancreatic lipase (6.46 ± 0.948 vs. 1.40 ± 0.460; P < 0.05), colipase (8.93 ± 2.138 vs. 2.36 ± 0.512; P < 0.05), and chymotrypsin (18.54 ± 3.125 vs. 9.69 ± 1.363; P < 0.05) were greater in group HCHOL than in group C. The HCHOL diet increased monounsaturated fatty acids and decreased saturated fatty acids in pancreatic plasma membranes compared with the standard chow. These results suggest a homeostatic adaptation of the pancreas to an atherogenic diet and a greater resistance to the development of lesions than exists in other organs. Further studies are needed, given the lack of research on this issue.

Keywords

Western diet exocrine pancreas membrane fatty acids cholesterol saturated fat rabbit

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Cite This Article

BURGOS, M. A. M., TORREGROSA, M. D. Y., GARCÃA, M. D. M., MILLÃN, M. B. L., CARRILLO, J. A. B., VELASCO, A. R., HERNÃNDEZ, Ã. G., ALMENDROS, M. M., MUÃ'OZ, E. M. D. V. (2015). Effects of a Western-style diet high in cholesterol and saturated faton the rabbit exocrine pancreas. Turkish Journal of Biology, Cilt: 39 - Sayı: 5, 765–774. https://ajindex.com/articles/181488

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