SavedAdd your journal

Journals / Turkish Journal of Biology / 2018 / Cilt: 42 - Sayı: 5

In vitro anticancer effect of tricyclic antidepressant nortriptyline on multiple myeloma

Ayşenur BİBER
İpek Z. DURUSU
Can ÖZEN
Pages
414–421
Publication Date
2018-10-25
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Drug repurposing has been proved to be an effective strategy to meet the urgent need for novel anticancer agents for multiple

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Drug repurposing has been proved to be an effective strategy to meet the urgent need for novel anticancer agents for multiple
📊
Key Findings & Data:Drug repurposing has been proved to be an effective strategy to meet the urgent need for novel anticancer agents for multiple
💡
Conclusion & Impact:Drug repurposing has been proved to be an effective strategy to meet the urgent need for novel anticancer agents for multiple
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Tricyclic antidepressant · combination chemotherapy · cancer

Abstract

Drug repurposing has been proved to be an effective strategy to meet the urgent need for novel anticancer agents for multiple

🔖

Cite This Article

BİBER, A., DURUSU, İ. Z., ÖZEN, C. (2018). In vitro anticancer effect of tricyclic antidepressant nortriptyline on multiple myeloma. Turkish Journal of Biology, Cilt: 42 - Sayı: 5, 414–421. https://ajindex.com/articles/181381

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Bilir A, Erguven M, Oktem G, Ozdemir A, Uslu A, Aktas E, Bonavinda B (2008). Potentiation of cytotoxicity by combination of imatinib and chlorimipramine in glioma. Int J Oncol 32: 829- 839. Bilir A, Erguven M, Yazihan N, Aktas E, Oktem G, Sabanci A (2010). Enhancement of vinorelbine-induced cytotoxicity and apoptosis by clomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y. J Neurooncol 100: 385-395.
  2. Chou TC (2006). Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58: 621-681.
  3. Desmarais JE, Looper KJ (2009). Interactions between tamoxifen and antidepressants via cytochrome P450 2D6. J Clin Psychiatry 70: 1688-1697.
  4. DiPaola RS (2002). To arrest or not to G 2-M cell-cycle arrest. Clin Cancer Res 8: 3311-3314.
  5. Frick LR, Rapanelli M (2013). Antidepressants: Influence on cancer and immunity? Life Sci 92: 525-532.
  6. Hall MD, Okabe M, Shen DW, Liang XJ, Gottesman MM (2008). The role of cellular accumulation in determining sensitivity to platinum-based chemotherapy. Annu Rev Pharmacol Toxicol 48: 495-535.
  7. Heim M, Scharifi M, Zisowsky J, Jaehde U, Voliotis D, Seeber S, Strumberg D (2005). The Raf kinase inhibitor BAY 43- 9006 reduces cellular uptake of platinum compounds and cytotoxicity in human colorectal carcinoma cell lines. Anticancer Drugs 16: 129-136.
  8. Hsu SS, Huang CJ, Chen JS, Cheng HH, Chang HT, Jiann BP, Lin KL, Wang JL, Ho CM, Jan CR (2004). Effect of nortriptyline on intracellular Ca2+ handling and proliferation in human osteosarcoma cells. Basic Clin Pharmacol Toxicol 95: 124-130.
  9. Jeon SH, Kim SH, Kim Y, Kim YS, Lim Y, Lee YH, Shin SY (2011). The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun 413: 311-317.
  10. Kabolizadeh P, Engelmann BJ, Pullen N, Stewart JK, Ryan JJ, Farrell NP (2012). Platinum anticancer agents and antidepressants: desipramine enhances platinum-based cytotoxicity in human colon cancer cells. J Biol Inorg Chem 17: 123-132.
  11. Kelly CM, Juurlink DN, Gomes T, Duong-Hua M, Pritchard KI, Austin PC, Paszat LF (2010). Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study. BMJ 340: c693. Kinjo T, Kowalczyk P, Kowalczyk M, Walaszek Z, Nishimaki T, Slaga TJ, Hanausek M (2009). Desipramine inhibits the growth of a mouse skin squamous cell carcinoma cell line and affects glucocorticoid receptor