SavedAdd your journal

Journals / Ağrı / 2012 / Cilt: 24 - Sayı: 1

Botulinum neuro-toxin aype-A in the treatment of chronic tension type headache associated with pericranial tenderness

Perikranial hassasiyet ile ilişkili kronik gerilim tipi baş ağrısında botulinum toksin tip A tedavisi

Ömer KARADAŞ
İlker Hüseyin İPEKDAL
Ümit Hıdır ULAŞ
Yaşar KÜTÜKÇÜ
ZEKİ ODABAŞI
Journal
Ağrı
Pages
9–14
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: BoNTA treatment may be usefull in the treatment of patients with chronic TTH associated with PT.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Both peripheral and central nociceptive mechanisms are responsible in chronic TTH.
📊
Key Findings & Data:Methods: 14 patients with chronic TTH with PT were included in the study. 50 units Botox® injection was applied to the pericranial muscles (5 units for each muscles bilaterally: frontal, temporal, semispinalis capitis, spenius capitis and trapezius muscles) for each patient.
💡
Conclusion & Impact:Conclusion: BoNTA treatment may be usefull in the treatment of patients with chronic TTH associated with PT.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Both peripheral and central nociceptive mechanisms are responsible in chronic TTH. Analgegics are used in the acute treatment of chronic TTH and antidepressants are used in prophylactic treatment. However, further studies are needed to bring out new treatment options. The aim of our study is to investigate the effectiveness of Botulinum Neuro-toxin Type-A (BoNTA) in the treatment of chronic TTH associated with pericranial tenderness (PT). Methods: 14 patients with chronic TTH with PT were included in the study. 50 units Botox® injection was applied to the pericranial muscles (5 units for each muscles bilaterally: frontal, temporal, semispinalis capitis, spenius capitis and trapezius muscles) for each patient. Severity of headache was evaluated by VAS (Visual Analogue Scale) and number of days with headache per month were recorded before treatment and 2nd and 4th months after treatment. Results: Number of days with headache per month were 19.57±3.25 before treatment, 15.28±4.37 at the 2nd month after treatment and 15.78±3.90 at the 4th month after treatment. Severity of headache was 65.71±9.16 before the treatment, 50.71±13.56 at the 2nd month after treatment and 54.28±10.35 at the 4th month after treatment (p<0.05). Frequency and severity of headache before treatment were significantly decreased at the 2nd month after treatment and this significance continued at the 4th month after treatment (p<0.05). Conclusion: BoNTA treatment may be usefull in the treatment of patients with chronic TTH associated with PT.

Özet

Amaç: Kronik gerilim tipi baş ağrısının (GTBA) gelişiminden periferal ve santral nosiseptif mekanizmalar sorumludur. Kronik GTBA’nın akut tedavisinde analjezikler, koruyucu tedavisinde ise antidepresanlar kullanılmakla birlikte, yeni tedavi seçeneklerinin sunulduğu çalışmalara da ihtiyaç vardır. Çalışmamızın amacı, perikranial hassasiyet ile ilişkili kronik gerilim tipi baş ağrılı hastalarda Botulinum Nörotoksin Tip A (BoNTA) uygulamasının ağrı şiddeti ve ağrı sıklığı üzerine etkisini incelemektir. Gereç ve Yöntem: Perikranial hassasiyeti olan 14 kronik GTBA’lı hasta çalışmaya alındı. Her hastanın perikranial kaslarına toplam 50 ünite Botox® enjeksiyonu (iki taraflı olmak üzere frontal kaslara 5; temporal kaslara 5; servikal bölgede semispinalis capitis, splenius capitis ve trapezius kaslarına 5’er ünite) uygulandı. Uygulama öncesinde ve uygulama sonrası 2. ve 4. aylarda her hastanın VAS (Görsel Analog Skalası) ile ağrı şiddetleri ve bir ay içerisindeki ağrılı gün sayısı kaydedildi. Bulgular: Hastaların tedavi öncesi bir ay içindeki ağrılı gün sayısı 19.57±3.25 gün iken tedavi sonrası 2. ayda 15.28±4.37 gün, 4. ayda 15.78±3.90 gün idi. Ağrı şiddeti tedavi öncesinde 65.71±9.16 iken tedavi sonrası 2. ayda 50.71±13.56 ve 4. ayda 54.28±10.35 idi. Tedavi sonrası 2. ayda bir ay içerisindeki ağrılı gün sayısı ve ağrı şiddeti tedavi öncesine göre istatistiksel olarak anlamlı düzeyde düşmüş idi (p<0.05). Bu istatistiksel anlamlılık 4. ayda da devam etmekte idi (p<0.05). Sonuç: Perikranial hassasiyeti olan KGBT hastalarında BoNTA uygulaması etkili tedavi olabilir.

🔖

Cite This Article

KARADAŞ, Ö., İPEKDAL, İ. H., ULAŞ, Ü. H., KÜTÜKÇÜ, Y., ODABAŞI, Z. (2012). Botulinum neuro-toxin aype-A in the treatment of chronic tension type headache associated with pericranial tenderness. Ağrı, Cilt: 24 - Sayı: 1, 9–14. https://ajindex.com/articles/178223

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders: 2nd ed. Cephalalgia 2004;24:9-160
  2. Svensson P. Muscle pain in the head: overlap between temporomandibular disorders and tension-type headaches. Curr Opin Neurol 2007;20(3):320-5
  3. Stovner LJ, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A, et al. The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia 2007;27(3):193-210
  4. Ashkenazi A, Silberstein SD. Headache management for the pain specialist. Reg Anesth Pain Med 2004;29(5):462-75
  5. Siva A. Başağrısı epidemiyolojisi. Türkiye Klinikleri 2003;(1):94- 7
  6. Silberstein SD, Lipton RB, Goadsby PJ. Tension-type headache: diagnosis and treatment. In: Clinical practice of headache. 2nd ed. Oxford: Martin Dunitz; 2002. p. 113-28
  7. Lipton RB, Hamelsky SW. Epidemiology and impact of headache. In: Silberstein SD, Lipton RB, Dalessio DJ, editors. Wolff’s headache and other head pain. 7th ed. New York: Oxford University Press; 2001. p. 85-107
  8. Jensen R, Olesen J. Initiating mechanisms of experimentally induced tension-type headache. Cephalalgia 1996;16(3):175- 82
  9. Jensen R. Peripheral and central mechanisms in tension-type headache: an update. Cephalalgia 2003;23:49-52
  10. Buchgreitz L, Lyngberg AC, Bendtsen L, Jensen R. Increased prevalence of tension-type headache over a 12-year period is related to increased pain sensitivity. A population study. Cephalalgia 2007;27(2):145-52
  11. Mense S. Nociception from skeletal muscle in relation to clinical muscle pain. Pain 1993;54(3):241-89
  12. Schmidt RF. Sensitization of peripheral nocisensors in muscle. In: Olesen J, Schoenen J, editors. Tension-type headache: classification, mechanisms and treatment. New York: Raven Press; 1993. p. 47-59
  13. Hu JW, Sessle BJ, Raboisson P, Dallel R, Woda A. Stimulation of craniofacial muscle afferents induces prolonged facilitatory effects in trigeminal nociceptive brain-stem neurones. Pain 1992;48(1):53-60
  14. Zissis NP, Harmoussi S, Vlaikidis N, Mitsikostas D, Thomaidis T, Georgiadis G, et al. A randomized, double-blind, placebocontrolled study of venlafaxine XR in out-patients with tension- type headache. Cephalalgia 2007;27(4):315-24
  15. Silver N. Headache (chronic tension-type). Am Fam Physician 2007;76(1):114-6
  16. Evers S. Status on the use of botulinum toxin for headache disorders. Curr Opin Neurol 2006;19(3):310-5