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Journals / Gülhane Tıp Dergisi / 2017 / Cilt: 59 - Sayı: 2

Early predictors of preterm labor and preeclampsia: A prospective study

Erken doğum ve preeklampsinin erken belirteçleri: prospektif bir çalışma

Ali BABACAN
Özgür DÜNDAR
MURAT MUHCU
Ercüment MÜNGEN
Vedat ATAY
Cem KIZILASLAN
Yaşam Kemal AKPAK
Pages
33–38
DOI
—
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Conclusions: These parameters deserve further investigation for their potential use (either alone or in combination) in the prediction of preeclampsia and preterm birth in the clinical setting.

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Objective & Hypothesis:Aims: This study aimed to investigate various clinical/biochemical parameters as potential predictors of preeclampsia and preterm labor. mmP-2, mmP-9, pregnancy-associated plasma protein A (PAPP-A), fms-like tyrosine kinase 1, and beta human chorionic gonadotropin (?-HCG) levels were measured and Doppler ultrasonography measurements were made in pregnant women at 11-14 weeks of gestation.
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Key Findings & Data:Results: Patients consisted of preeclampsia and/or preterm labor cases (n=40) and selected controls were pregnant women with a normal pregnancy period who delivered between 37 and 40 weeks of gestation (n=55). multivariate analysis identified high fms-like tyrosine kinase 1 level (Or, 1.004; 95% CI: 1.001-1.007, p= 0.005), high UtA PI (Or, 30.6; 95% CI: 1.1-852, p= 0.044) and presence of any notch (Or, 36.4; 95% CI: 1.6-826, p= 0.024) as independent predictors of preeclampsia; whereas only maternal mmP-9 level emerged as a significant predictor of preterm birth, (Or, 1.001; 95% CI: 1.000-1.001, p< 0.001).
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Conclusion & Impact:Conclusions: These parameters deserve further investigation for their potential use (either alone or in combination) in the prediction of preeclampsia and preterm birth in the clinical setting.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aims: This study aimed to investigate various clinical/biochemical parameters as potential predictors of preeclampsia and preterm labor. mmP-2, mmP-9, pregnancy-associated plasma protein A (PAPP-A), fms-like tyrosine kinase 1, and beta human chorionic gonadotropin (?-HCG) levels were measured and Doppler ultrasonography measurements were made in pregnant women at 11-14 weeks of gestation. Findings were recorded and patients were followed until delivery. Results: Patients consisted of preeclampsia and/or preterm labor cases (n=40) and selected controls were pregnant women with a normal pregnancy period who delivered between 37 and 40 weeks of gestation (n=55). multivariate analysis identified high fms-like tyrosine kinase 1 level (Or, 1.004; 95% CI: 1.001-1.007, p= 0.005), high UtA PI (Or, 30.6; 95% CI: 1.1-852, p= 0.044) and presence of any notch (Or, 36.4; 95% CI: 1.6-826, p= 0.024) as independent predictors of preeclampsia; whereas only maternal mmP-9 level emerged as a significant predictor of preterm birth, (Or, 1.001; 95% CI: 1.000-1.001, p< 0.001). Conclusions: These parameters deserve further investigation for their potential use (either alone or in combination) in the prediction of preeclampsia and preterm birth in the clinical setting.

Özet

Bu çalışmanın amacı, değişik klinik ve biyokimyasal parametreleri, preeklampsi ve erken doğumun olası belirteçleri olarak değerlendirmektir. Gebeliğinin 11-14 haftalarında olan kadınlarda mmP-2, mmP-9, gebelik ile ilişkili plazma protein A (PAPP-A), fms-benzeri tirozin kinaz 1, insan beta koriyonik gonadotropini (?-HCG) düzeyleri ölçülmüş ve Doppler ultrason ölçümleri yapılmıştır. Bulgular kaydedilmiş ve hastalar doğuma kadar izlenmiştir. Preeklampsi ve/veya erken doğum gelişen 40 hasta çalışma grubunu, gebeliğinin 37 ile 40. haftalarında normal doğum yapmış seçilmiş 55 hasta kontrol grubunu oluşturmuştur. Çok değişkenli analiz, yüksek fms-benzeri tirozin kinaz 1 düzeyini (Or, 1.004; 95% CI: 1.001-1.007, p= 0.005), yüksek UtA PI değerini (Or, 30.6; 95% CI: 1.1-852, p= 0.044) ve herhangi bir notch olması durumunu (Or, 36.4; 95% CI: 1.6-826, p= 0.024) preeklampsinin bağımsız belirteçleri olarak belirlemiştir. Erken doğumun anlamlı belirteci olarak ise sadece annenin mmP-9 düzeyi bulunmuştur (Or, 1.001; 95% CI: 1.000-1.001, p< 0.001). Klinik ortamda bu parametrelerin preeklampsi ve erken doğumu tahmin etmedeki değerinin (tek başına ya da kombinasyon olarak) daha ileri çalışmalarda araştırılması gerekmektedir.

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Cite This Article

BABACAN, A., DÜNDAR, Ö., MUHCU, M., MÜNGEN, E., ATAY, V., KIZILASLAN, C., AKPAK, Y. K. (2017). Early predictors of preterm labor and preeclampsia: A prospective study. Gülhane Tıp Dergisi, Cilt: 59 - Sayı: 2, 33–38. https://ajindex.com/articles/178143

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