Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Some isoxazolo[4,5-d]pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity.
📊
Key Findings & Data:The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references.
💡
Conclusion & Impact:Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Isoxazolo[4 · 5-d]pyridazin-4(5H)-one · hot-plate test
Abstract
Some isoxazolo[4,5-d]pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).
Özet
Some isoxazolo[4,5-d]pyridazin4(5H)-one derivatives were synthesized and tested for their analgesic activity. The analgesic activities of the compounds were determined by hot-plate and acetic acid writhing tests using morphine and diclofenac as references. Compounds 4a, 4f, 4g, and 4i (25 mg/kg) showed analgesic profiles similar to that of morphine (5 mg/kg).
TAN, O. Ü., ÖZADALI, K., YEŞİLYURT, Ö. (2011). Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives. Turkish Journal of Chemistry, Cilt: 35 - Sayı: 1, 121–130. https://ajindex.com/articles/174933