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Journals / Eastern Journal of Medicine / 2019 / Cilt: 24 - Sayı: 4

Association Between Endothelial Nitric Oxide Synthase Polymorphisms T786C and G894T and Ischaemic Stroke

Vedat ÇİLİNGİR
Ahmet DÖNDER
AYSEL MİLANLIOĞLU
Abdullah YILGÖR
Temel TOMBUL
Pages
472–477
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results suggest that the eNOS T786C gene polymorphism is associated with LAA in IS patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Endothelial nitric oxide synthase (eNOS) gene polymorphisms are suspected to increase the risk of ischaemic stroke (IS). eNOS-synthesized NO regulates vascular tone and inhibits the progression of atherosclero sis.
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Key Findings & Data:The present study aimed to determine the association between eNOS polymorphisms G894T and T786C and IS.
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Conclusion & Impact:Our results suggest that the eNOS T786C gene polymorphism is associated with LAA in IS patients.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Endothelial nitric oxide synthase (eNOS) gene polymorphisms are suspected to increase the risk of ischaemic stroke (IS). eNOS-synthesized NO regulates vascular tone and inhibits the progression of atherosclero sis. The present study aimed to determine the association between eNOS polymorphisms G894T and T786C and IS. Sixty acute IS patients (32 male, 28 female) were included and classified in accordance with the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Genotypes of patients with eNOS G894T and eNOS T786C polymorphisms were determined through polymerase chain reaction. Significant differences were observed in the distribution of eNOS T786C polymorphism among IS subgroups. The eNOS T786C polymorphism heterozygote (TC) and homozygote (CC) genotypes more frequent in patients in the large artery atherosclerosis (LAA) subgroup. Considering a dominant model of inheritance for eNOS T786C polymorphism, the risk of IS was higher for the LAA subgroup than for other IS subgroups. Among potential haplotypes, the eNOS 786C+ eNOS 894G haplotype was associated with an increased risk of LAA; however, this finding was not statistically significant. eNOS gene polymorphisms are suspected to increase the risk of ischaemic stroke. Our results suggest that the eNOS T786C gene polymorphism is associated with LAA in IS patients.

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Cite This Article

ÇİLİNGİR, V., DÖNDER, A., MİLANLIOĞLU, A., YILGÖR, A., TOMBUL, T. (2019). Association Between Endothelial Nitric Oxide Synthase Polymorphisms T786C and G894T and Ischaemic Stroke. Eastern Journal of Medicine, Cilt: 24 - Sayı: 4, 472–477. https://ajindex.com/articles/170410

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