Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2017 / Cilt: 23 - Sayı: 1

Total Blood Lymphocyte Count Alteration During and After Pregnancy

Pages
11–13
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Pregnancy and related hormones have a negative impact on total blood lymphocyte level.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: To investigate the impact of gestational changes on blood lymphocyte count in healthy pregnancies.
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Key Findings & Data:STUDY DESIGN: This retrospective study is consisted of 108 consecutive normal pregnancies who delivered at our department in December 2015.
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Conclusion & Impact:Pregnancy and related hormones have a negative impact on total blood lymphocyte level.
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: To investigate the impact of gestational changes on blood lymphocyte count in healthy pregnancies. STUDY DESIGN: This retrospective study is consisted of 108 consecutive normal pregnancies who delivered at our department in December 2015. High-risk pregnancies with poor neonatal outcome and pregnancies with maternal disorders which may affect lymphocyte counts were excluded from the study. “Complete blood count” results of the patients were obtained from the computerized data base system of Hacettepe University Hospital. Blood samples of patients which were withdrawn a) prior to pregnancy (1-6 months before getting pregnant), b) during pregnancy (11-14th gestational weeks) and c) post-partum first day were used in this study. RESULTS: The mean blood lymphocyte count was 2049.07 (±758.69) in patients before their pregnancies. The mean lymphocyte count decreased to 1850.93 and 1625 during pregnancy and after delivery respectively. A statistically significant decrease was found between three periods (before, during, and postpartum 1st day) (p:0.003). CONCLUSION: We have shown a significant decrease in total lymphocyte levels during pregnancy, consistent with the data presented in the literature. Pregnancy and related hormones have a negative impact on total blood lymphocyte level.

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Cite This Article

ÖRGÜL, G., SOYAK, B., AKÇİN, O. P., BEKSAÇ, M., BEKSAÇ, M. S. (2017). Total Blood Lymphocyte Count Alteration During and After Pregnancy. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 23 - Sayı: 1, 11–13. https://ajindex.com/articles/167558

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References (12)

  1. Robertson SA. Immune regulation of conception and embryo implantation-all about quality control? J Reprod Immunol 2010;85(1):51-7
  2. Dekel N, Gnainsky Y, Granot I, Mor G. Inflammation and implantation. Am J Reprod Immunol 2010;63(1):17-21
  3. Valdimarsson H, Mulholland C, Fridriksdottir V, Coleman DV. A longitudinal study of leucocyte blood counts and lymphocyte responses in pregnancy: a marked early increase of monocyte-lymphocyte ratio. Clin Exp Immunol 1983;53(2):437-43
  4. Tilburgs T, Claas FH, Scherjon SA. Elsevier Trophoblast Research Award Lecture: Unique properties of decidual T cells and their role in immune regulation during human pregnancy. Placenta 2010;31 Suppl:S82-6
  5. Milman N, Bergholt T, Byg KE, Eriksen L, Hvas AM. Reference intervals for haematological variables during normal pregnancy and postpartum in 434 healthy Danish women. Eur J Haematol 2007;79(1):39-46
  6. Iwatani Y, Amino N, Tachi J, Kimura M, Ura I, Mori M, et al. Changes of lymphocyte subsets in normal pregnant and postpartum women: postpartum increase in NK/K (Leu 7) cells. Am J Reprod Immunol Microbiol 1988; 18(2):52-5
  7. Akinbami AA, Ajibola SO, Rabiu KA, Adewunmi AA, Dosunmu AO, Adediran A, et al. Hematological profile of normal pregnant women in Lagos, Nigeria. International Journal of Women’s Health 2013;5:227-32
  8. Lurie S, Rahamim E, Piper I, Golan A, Sadan O. Total and differential leukocyte counts percentiles in normal pregnancy. Eur J Obstet Gynecol Reprod Biol 2008;136 (1):16-9
  9. Kühnert M, Strohmeier R, Stegmüller M, Halberstadt E. Changes in lymphocyte subsets during normal pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology 1998;76(2):147-51
  10. Rijhsinghani AG, Bhatia SK, Tygrett LT, Waldschmidt TJ. Effect of pregnancy on thymic T cell development. Am J Reprod Immunol 1996;35(6):523-8
  11. Kendall MD, Clarke AG. The thymus in the mouse changes its activity during pregnancy: a study of the microenvironment. Journal of anatomy 2000;197(03):393- 411
  12. Jaiswal M, Mallers T, Chaouat G, Gilman-Sachs A, Beaman K. Pregnancy alters T-cell development in the mouse thymus. J Immunol 2012;188(1 Supplement): 115.11 13. Onwukeme KE. Puerperal Haematological Indices in the Nigerian. African Journal of Medicine and Medical Sciences 1992;21(2):51-5.