Journals / Ege Tıp Dergisi / 2019 / Cilt: 58 - Sayı: 0

Epidemiological and overall survival characteristics of central nervous system tumors in Ege University Hospital

Ege Üniversitesi Hastanesi merkezi sinir sistemi tümörlerinin epidemiyolojik ve genel sağ kalım özellikleri

Pages
10–18
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Aim: The aim of this study was to evaluate the epidemiological and overall survival characteristics of 5877 patients diagnosed with Central Nervous System tumors in the database of Ege University Faculty of Medicine and compare them with the literature.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The aim of this study was to evaluate the epidemiological and overall survival characteristics of 5877 patients diagnosed with Central Nervous System tumors in the database of Ege University Faculty of Medicine and compare them with the literature.
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Key Findings & Data:Materials and Methods: 5877 cases of CNS cancer diagnosed at Ege University Hospital between 1992 and 2017 were recorded by specially trained and certified cancer registry staff of Ege University Cancer Control, Application and Research Center(EUCRC) analyzed using linear modeling method and Chi-Square test and p <0.05 was considered statistically significant.
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Conclusion & Impact:Conclusion: In general, EUCRC data and literature data is overlapping and increase in the incidence of CNS tumors is also seen in the data of CBTRUS, GLOBOCAN and Turkey Cancer Statistics.
🔬Design:Modeling & Simulation
📍Scope:2017 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of this study was to evaluate the epidemiological and overall survival characteristics of 5877 patients diagnosed with Central Nervous System tumors in the database of Ege University Faculty of Medicine and compare them with the literature. Materials and Methods: 5877 cases of CNS cancer diagnosed at Ege University Hospital between 1992 and 2017 were recorded by specially trained and certified cancer registry staff of Ege University Cancer Control, Application and Research Center(EUCRC) analyzed using linear modeling method and Chi-Square test and p <0.05 was considered statistically significant. Results: According to EUCRC data, the total number of cancer cases diagnosed at Ege University Hospital between 1992 and 2017 was 117139 and CNS tumors accounted for 5% of all cancer cases with 5877 cases. 66.7% of the most common brain tumors were observed. CNS tumors were most frequently observed in the 50-59 age range. Brain tumors were most commonly located in the frontal lobe. Diffuse astrocytic and oligodendroglial tumors (63%) were the most common group among brain tumors. Similar to all CNS tumors, a linear increase was observed in the total number of brain tumors between 1992 and 2017. The 5-year survival rate was found to be the highest in meningeal tumors with a rate of 86.3%. It was observed that survival rates were the lowest in the 70-year-old group and Glioblastomas were more common in males (60.4%). The mean survival time in glioblastomas was 11.6 months for males and 13.3 months for females. Conclusion: In general, EUCRC data and literature data is overlapping and increase in the incidence of CNS tumors is also seen in the data of CBTRUS, GLOBOCAN and Turkey Cancer Statistics.

Özet

Amaç: Bu çalışmanın amacı, Ege Üniversitesi Tıp Fakültesi Hastanesi veri tabanında bulunan, merkezi sinir sistemi (MSS) tümörü tanısı ile tedavi edilen 5877 adet olgunun epidemiyolojik ve genel sağ kalım özelliklerini istatistiksel açıdan değerlendirmek ve literatür ile karşılaştırmaktır. Gereç ve Yöntem: 1992 ile 2017 yılları arasında Ege Üniversitesi Tıp Fakültesi Hastanesinde tanı alan 5877 adet MSS kanseri olgusu, Ege Üniversitesi Kanserle Savaş, Uygulama ve Araştırma Merkezi’nin (EÜKAM) özel eğitimli ve sertifikalı kanser kayıt elemanları tarafından kayıt altına alınan veriler, Ki-kare testi ve doğrusal modelleme yöntemi kullanılarak analiz edilmiş, p<0,05 değeri anlamlı kabul edilmiştir. Bulgular: EÜKAM verilerine göre 1992 ile 2017 yılları arasında Ege Üniversitesi Tıp Fakültesi Hastanesinde tanı olan toplam kanser olgu sayısı 117139 olarak bulunmuş olup MSS tümörleri, 5877 adet olgu ile tüm kanser olgularının %5’ini oluşturmuştur. %66,7 oranında en sık beyin tümörleri izlenmiştir. MSS tümörleri en sık 50-59 yaş aralığında izlenmiştir. Beyin tümörlerinin en sık frontal lob lokalizasyonunda yerleştiği görülmüştür. Beyin tümörleri arasında diffüz astrositik ve oligodendroglial tümörler (%63) en sık izlenen grup olmuştur. Beyin tümörlerinin toplam sayısında da tüm MSS tümörleriyle benzer şekilde, 1992-2017 yılları arasında doğrusal bir artış izlenmiştir. Beş yıllık sağ kalım oranı, %86,3 oranı ile meninks tümörlerinde en fazla olduğu bulunmuştur. Sağ kalım oranlarının, 70 yaş ve üzeri grupta en düşük oranda olduğu, glioblastomların, erkeklerde (%60,4) daha sık görüldüğü izlenmiştir. Glioblastomlarda ortalama sağ kalım süresi, erkeklerde 11,6 ay, kadınlarda ise 13,3 ay olduğu bulunmuştur. Sonuç: Genel olarak EÜKAM verileri ve literatür bilgileri örtüşmektedir ve MSS tümörlerinin insidansında artış olduğu; CBTRUS, GLOBOCAN ve Türkiye Kanser İstatistiği verilerinde de izlenmektedir.

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Cite This Article

ÖZGİRAY, E., ÇALIŞKAN, K. E., ÇAĞLI, M. S., YURTSEVEN, T., ERTAN, Y., AKALIN, T., ŞANLI, U., KAMER, S., ANACAK, Y., HAYDAROĞLU, A. (2019). Epidemiological and overall survival characteristics of central nervous system tumors in Ege University Hospital. Ege Tıp Dergisi, Cilt: 58 - Sayı: 0, 10–18. https://ajindex.com/articles/166987

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