Journals / Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi / 2025 / Cilt: 41 Sayı: 3

Assessment of the Presence of Aflatoxins and Pesticides in Food and Their Public Health Risks

Aflatoksin ve Pestisitlerin Gıdalardaki Varlığı ve Halk Sağlığı Açısından Risk Değerlendirmesi

Semra Kaçar(Mardin Artuklu University)0000-0002-9869-9045
Pages
770–782
Publication Date
2025-12-31
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The study aims to support the development of effective public health policies and to promote greater consumer awareness regarding these food safety hazards.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aflatoxins and pesticide residues are among the most critical chemical contaminants posing a threat to food safety worldwide.
📊
Key Findings & Data:Pesticides, extensively applied in agricultural production to enhance yield and prevent crop losses, may cause serious adverse effects on human health when used improperly or without regulation.
💡
Conclusion & Impact:The study aims to support the development of effective public health policies and to promote greater consumer awareness regarding these food safety hazards.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Aflatoksin · Pestisit · Gıda Güvenliği

Abstract

Aflatoxins and pesticide residues are among the most critical chemical contaminants posing a threat to food safety worldwide. Pesticides, extensively applied in agricultural production to enhance yield and prevent crop losses, may cause serious adverse effects on human health when used improperly or without regulation. Likewise, aflatoxins—secondary metabolites produced by Aspergillus species under warm and humid conditions—can contaminate food products and exert toxic, mutagenic, and carcinogenic effects, particularly targeting the liver. This review examines the occurrence of aflatoxins and pesticide residues in foods, their detection methods, regulatory standards, and associated public health risks in light of recent scientific evidence. In addition, challenges related to monitoring systems, consumer awareness, and the disproportionate impact on developing countries are discussed. The study aims to support the development of effective public health policies and to promote greater consumer awareness regarding these food safety hazards.

Özet

Aflatoksinler ve pestisit kalıntıları, küresel gıda güvenliğini tehdit eden en önemli kimyasal kontaminantlar arasında yer almaktadır. Tarımsal üretimde verimliliği artırmak ve ürün kayıplarını azaltmak amacıyla yaygın olarak kullanılan pestisitler, yanlış veya yetersiz düzenlemelerle kullanıldığında ciddi sağlık sorunlarına yol açabilmektedir. Benzer şekilde, Aspergillus türleri tarafından sıcak ve nemli koşullarda üretilen sekonder metabolitler olan aflatoksinler, gıdalara bulaşarak özellikle karaciğer üzerinde toksik, mutajenik ve kanserojen etkilere neden olabilmektedir. Bu derlemede, gıdalarda aflatoksin ve pestisit kalıntılarının varlığı, tespit yöntemleri, yasal düzenlemeler ve halk sağlığı açısından oluşturdukları riskler güncel bilimsel veriler ışığında ele alınmaktadır. Ayrıca zayıf izleme sistemleri, sınırlı tüketici farkındalığı ve gelişmekte olan ülkelerin artan hassasiyeti gibi sorunlara da dikkat çekilmektedir. Çalışma, bu kritik gıda güvenliği tehditlerine ilişkin halk sağlığı politikalarının geliştirilmesine ve tüketici bilincinin artırılmasına katkı sağlamayı amaçlamaktadır.

🔖

Cite This Article

Başhan, U., Kaçar, S. (2025). Assessment of the Presence of Aflatoxins and Pesticides in Food and Their Public Health Risks. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi, Cilt: 41 Sayı: 3, 770–782. https://doi.org/10.65520/erciyesfen.1720375

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (56)

  1. World Health Organization. 2020. The future of food safety: transforming knowledge into action for people, economies and the environment: technical summary of the 2019 international food safety conferences. World Health Organization.
  2. Ramadan, N. A., Al-Ameri, H. A. 2022. Aflatoxins. Aflatoxins-occurrence, detoxification, determination and health risks. IntechOpen. Available at: http://dx.doi.org/10.5772/intechopen.97292.
  3. Liu, Y., Wu, F. 2010. Global burden of aflatoxin-induced hepatocellular carcinoma: a risk assessment. Environmental health perspectives, 118(6), 818-824. http://dx.doi.org/ 10.1289/ehp.0901388.
  4. Mostafalou, S., Abdollahi, M. 2017. Pesticides: an update of human exposure and toxicity. Archives of toxicology, 91(2), 549-599. http://dx.doi.org/ 10.1007/s00204-016-1849-x.
  5. Adem, R. 2011. Three years of surveillance (2008-10) for the assessment of contaminants residues in milk produced in Kosovo. Università degli studi di Padova. Phd. Thesis.
  6. Singh, A. K., Singh, M. P., Parmanand, Bahadur, V., Rajput, S.S. 2025. 10 Mycotoxins as Food Contaminants and Their Detection Methods. In book: Nanomaterials for Electrochemical Sensing. http://dx.doi.org/10.1201/9781032654874-10
  7. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 2008. IARC monographs on the evaluation of carcinogenic risks to humans. Volume 97. 1, 3-butadiene, ethylene oxide and vinyl halides (vinyl fluoride, vinyl chloride and vinyl bromide). IARC monographs on the evaluation of carcinogenic risks to humans, 97, 3.
  8. Deveci, O., Sezgin, E. 2006. Aflatoxin M1 in milk and milk products and situation in our country. (Süt ve ürünlerinde aflatoksin M1 ve ülkemizdeki durum). Akademik Gıda, 4(4), 11-16.
  9. Wild, C. P., Gong, Y. Y. 2010. Mycotoxins and human disease: a largely ignored global health issue. Carcinogenesis, 31(1), 71-82. http://dx.doi.org/10.1093/carcin/bgp264.
  10. Yentür, G., Er, B. 2012. The evaluation of the aflatoxin presence in foods. (Gıdalarda aflatoksin varlığının değerlendirilmesi). Türk Hijyen ve Deneysel Biyoloji Dergisi, 69(1), 41-52. http://dx.doi.org/10.5505/TurkHijyen.2012.54154.
  11. Mottaghianpour, E., Nazari, F., Mehrasbi, M. R., Hosseini, M. J. 2017. Occurrence of aflatoxin B1 in baby foods marketed in Iran. Journal of the Science of Food and Agriculture, 97(9), 2690-2694. http://dx.doi.org/10.1002/jsfa.8092.
  12. Reddy, B. N., Raghavender, C. R. 2007. Outbreaks of aflatoxicoses in India. African journal of food, agriculture, nutrition and development, 7(5). http://dx.doi.org/10.18697/ajfand.16.2750
  13. Duman Aydın, B., Çelik, A., Güran, H. Ş. 2023. Determination of Aflatoxin M1 Levels in Raw Milk of Cow and Anatolian Water Buffalo. (İnek ve Anadolu Manda Çiğ Sütlerinde Aflatoksin M1 Düzeyinin Belirlenmesi). Firat Universitesi Saglik Bilimleri Veteriner Dergisi, 37(1).
  14. İnanç, A. L. 2024. Determination of Aflatoxin Contamination of Bulk and Packed Spice Red Peppers. (Dökme ve ambalajlı baharatlık kırmızı biberlerin aflatoksin kontaminasyonunun belirlenmesi). Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, 27(3), 695-703. https://doi.org/10.18016/ksutarimdoga.vi.1341076
  15. Dönmez, D., Uzun, M. 2024. Investigating the aflatoxin M1 level in butter samples collected from markets in winter and Spring. (Kış ve ilkbaharda marketlerden toplanan tereyağı örneklerinde Aflatoksin M1 düzeyinin araştırılması). Food and Health, 10(3), 235-243. https://doi.org/10.3153/FH23022.
  16. Naresh Magan, N. M., Aldred, D. 2007. Post-harvest control strategies: minimizing mycotoxins in the food chain. https://doi.org/10.1016/j.ijfoodmicro.2007.07.034
  17. Medina, A., Rodriguez, A., Magan, N. 2014. Effect of climate change on Aspergillus flavus and aflatoxin B1 production. Frontiers in microbiology, 5, 348. https://doi.org/10.3389/fmicb.2014.00348.
  18. Battilani, P., Toscano, P., Van der Fels-Klerx, H. J., Moretti, A., Camardo Leggieri, M., Brera, C., Robinson, T. 2016. Aflatoxin B1 contamination in maize in Europe increases due to climate change. Scientific reports, 6(1), 24328. https://doi.org/10.1038/srep24328.
  19. Karaoğlan, H., Yanık, E. D., Tunç, N. 2022. The presence of aflatoxin M1 in milk and dairy products in our country and in the World. (Ülkemizde ve dünyada süt ve süt ürünlerinde aflatoksin M1 varlığı). Atatürk Üniversitesi Ziraat Fakültesi Dergisi, 53(1), 81-87. https://doi.org/10.54614/AUAF.2022.995228.
  20. Mutiga, S. K., Were, V., Hoffmann, V., Harvey, J. W., Milgroom, M. G., Nelson, R. J. 2014. Extent and drivers of mycotoxin contamination. Phytopathology, 104(11), 1221-1231. https://doi.org/10.1094/PHYTO-01-14-0006-R.
  21. Mesterhazy, A., Szieberth, D., Tóth, E. T., Nagy, Z., Szabó, B., Herczig, B., Tóth, B. 2022. The role of preharvest natural infection and toxin contamination in food and feed safety in maize, South-East Hungary, 2014–2021. Journal of Fungi, 8(10), 1104. https://doi.org/10.3390/jof8101104.
  22. Kaya, S. B. 2012. Bazı organik tarım ürünlerinde aflatoksin, okratoksin a ve fumonisin varlığının araştırılması (Master's thesis, Fen Bilimleri Enstitüsü).
  23. Beyuo, J., Sackey, L.N.A., Yeboah, C. Kayoung, P.Y., Koudadje, D. 2024. The implications of pesticide residue in food crops on human health: a critical review. Discover Agriculture, 2, 123. https://doi.org/10.1007/s44279-024-00141-z.
  24. Tiryaki, O. 2016. Pesticide residue analyses and researches carried out inTurkey. (Türkiye’de yapılan pestisit kalıntı analiz ve çalışmaları). Erciyes Üniversitesi Fen Bilimleri Enstitüsü Fen Bilimleri Dergisi, 32(1), 72-80.
  25. Galli, F.S., Mollari, M., Tassinari, V., Alimonti, C., Ubaldi, A., Cuva, C., Marcoccia, D. 2024. Overview of human health effects related to glyphosate exposure. Frontiers in Toxicology, 18(6), 1474792. https://doi.org/10.3389/ftox.2024.1474792.
  26. Erbek, E., Özyörük, A., Arslan, Ü. 2018. Determination of attitudes and behaviors of fruit producers towards pesticide use in Gürsu and Kestel districts of Bursa province. (Bursa ili Gürsu ve Kestel ilçelerindeki meyve üreticilerinin pestisit kullanımına yönelik tutum ve davranışlarının belirlenmesi. Journal of Agricultural Faculty of Bursa Uludag University, 32(2), 69-76.
  27. Adesanya, A.W., Beauchamp, M.J., Lavine, M.D., Lavine, L.C., Zhu, F., Walsh, D.B. 2019. Physiological resistance alters behavioral response of Tetranychus urticae to acaricides. Scientific Reports, 9, 19308. https://doi.org/10.1038/s41598-019-55708-4.
  28. Witmer, G. 2019. The changing role of rodenticides and their alternatives in the management of commensal rodents. Human-Wildlife Interactions, 13(2), https://doi.org/10.26077/zqda-v434.
  29. Sikora, R.A.; Coyne, D.L.; Hallmann, J.; Timper, P. Reflections and challenges: Nematology in subtropical and tropical agriculture. In plant parasitic nematodes in subtropical and tropical agriculture, 3rd ed.; Sikora, R.A., Coyne, D.L., Hallmann, J., Timper, P., Eds.; CAB International: Boston, MA, USA, 2018; pp. 1–19.
  30. Doğan, F. N., Karpuzcu, M. E. 2019. Current status of agricultural pesticide pollution in Turkey and evaluation of alternative control methods. (Türkiye’de tarım kaynaklı pestisit kirliliğinin durumu ve alternatif kontrol tedbirlerinin incelenmesi). Pamukkale Üniversitesi Mühendislik Bilimleri Dergisi, 25(6), 734-747. https://doi.org/10.5505/pajes.2018.53189.
  31. Tarone, R. E. 2018. On the International Agency for Research on Cancer classification of glyphosate as a probable human carcinogen. European Journal of Cancer Prevention, 27(1), 82-87. https://doi.org/10.1097/CEJ.0000000000000289.
  32. Kaya, T., Tuna, A. L. 2019. Investigation of pesticide residue levels in fruit and vegetables collected from three farmers market in İzmir province. (İzmir ilindeki üç halk pazarından alınan meyve ve sebze örneklerindeki pestisit kalıntı miktarının araştırılması). Türkiye Tarımsal Araştırmalar Dergisi, 6(1), 32-38. https://doi.org/10.19159/tutad.437474.
  33. Uçak, H., Karaca, İ., Güven, Ö. 2014. The effects of some biopesticides on Frankliniella occidentalis (Pergade) (Thripidae: Thysanoptera). (Bazı biyopestisitlerin Frankliniella occidentalis (Pergande)(Thripidae: Thysanoptera)’e etkileri). Türkiye Biyolojik Mücadele Dergisi, 5(2), 137-148.
  34. Çevre, Ş., Bakanlığı, İ. D. 2022. Çevresel göstergeler.
  35. Wang, S., Wang, X., He, Q., Lin, H., Chang, H., Sun, H., Liu, Y. 2022. Simultaneous determination of seven pesticides and metabolite residues in litchi and longan through high-performance liquid chromatography-tandem mass spectrometry with modified QuEChERS. Molecules, 27(17),5737. https://doi.org/10.3390/molecules27175737.
  36. Wu, F., Khlangwiset, P. 2010. Health economic impacts and cost-effectiveness of aflatoxin-reduction strategies in Africa: case studies in biocontrol and post-harvest interventions. Food additives and contaminants, 27(4), f6-509. https://doi.org/10.1080/19440040903437865.
  37. World Health Organization. 2023. Evaluation of certain contaminants in food: ninety-third report of the joint fao/who expert committee on food additives. World Health Organization.
  38. Khandelwal, A., Joshi, R., Shrivastava, M., Singh, R. 2022. Maximum residue limit (MRL) of pesticides and their global significance. International Journal of Agriculture, Environment and Biotechnology, 15(2), 247-257. https://doi.org/10.30954/0974-1712.02.2022.13.
  39. Qıao, X. 2023. A critical review of dietary risk assessment of pesticide residues in foods. Chinese Journal of Pesticide Science, 25(1), 12-22. https://doi.org/10.16801/j.issn.1008-7303.2023.0007.
  40. Benkerroum, N. 2020. Aflatoxins: Producing-molds, structure, health issues and incidence in Southeast Asian and Sub-Saharan African countries. International journal of environmental research and public health, 17(4), 1215. https://doi.org/10.3390/ijerph17041215.
  41. Czyżewski, B., Kryszak, Ł. 2022. Sustainable agriculture policies for human well-being. Integrated efficiency approach. Switzerland: Springer Nature. https://doi.org/10.1007/978-3-031-09796-6.
  42. Hell, K., Mutegi, C. 2011. Aflatoxin control and prevention strategies in key crops of Sub-Saharan Africa. African Journal of Microbiology Research, 5(5), 459-466.
  43. Benbrook, C. M., Baker, B. P. 2014. Perspective on dietary risk assessment of pesticide residues in organic food. Sustainability, 6(6), 3552-3570. https://doi.org/10.3390/su6063552.
  44. Kaushik, G., Satya, S., Naik, S. N. 2009. Food processing a tool to pesticide residue dissipation–A review. Food research international, 42(1), 26-40. https://doi.org/10.1016/j.foodres.2008.09.009.
  45. Keikotlhaile, B. M., Spanoghe, P., Steurbaut, W. 2010. Effects of food processing on pesticide residues in fruits and vegetables: A meta-analysis approach. Food and Chemical Toxicology, 48(1), 1-6. https://doi.org/10.1016/j.fct.2009.10.031.
  46. Bhanti, M., Taneja, A. 2007. Contamination of vegetables of different seasons with organophosphorous pesticides and related health risk assessment in northern India. Chemosphere, 69(1), 63-68. https://doi.org/10.1016/j.chemosphere.2007.04.071.
  47. Patel, T. K. 2025. Mycotoxins: Challenges and Strategies for Mitigation. In Mycological Inventions for Sustainable Agriculture and Food Production (pp. 377-406). IGI Global Scientific Publishing.
  48. Boobis, A. R., Cohen, S. M., Dellarco, V., McGregor, D., Meek, M. E., Vickers, C., Farland, W. 2006. IPCS framework for analyzing the relevance of a cancer mode of action for humans. Critical reviews in toxicology, 36(10), 781-792. https://doi.org/10.1080/10408440600977677.
  49. Abrol, D. P., Shankar, U. (Eds.). 2012. Integrated pest management: principles and practice. CABI.
  50. Cycoń, M., Mrozik, A., Piotrowska-Seget, Z. 2017. Bioaugmentation as a strategy for the remediation of pesticide-polluted soil: A review. Chemosphere, 172, 52-71. https://doi.org/10.1016/j.chemosphere.2016.12.129.
  51. Biniş, A. B., Demir, T. 2023. Investigation of aflatoxin M1 presence in open and packaged ice creams. (Açık ve Ambalajlı Dondurmalarda Aflatoksin M1 Varlığının Araştırılması). Instıtute of Health Sciences Journal, 8(3), 418-427. https://doi.org/10.51754/cusbed.1326151.
  52. Şen, L., Nas, S. 2010. Occurrence of mycotoxins in dried figs, raisins and paprika. (Kuru incir, üzüm ve kırmızıbiberlerde mikotoksin varlığı). Akademik Gıda, 8(3), 24-32.
  53. Özercan, B., Taşcı, R. 2022. Investigation of pesticide use in Türkiye in terms of provinces, regions and pesticide groups. (Türkiye’de pestisit kullanımının iller, bölgeler ve pestisit grupları açısından incelenmesi). Ziraat Mühendisliği, (375), 75-88. https://doi.org/10.33724/zm.1120599.
  54. Yılmaz, H., Düzenli, A., Dağ, M. M. 2024. Pesticide use and legal regulations in the World, European Union Countries and Türkiye. (Dünya, Avrupa Birliği Ülkeleri ve Türkiye’de Pestisit Kullanımı ve Yasal Düzenlemeler). Türkiye Tarımsal Araştırmalar Dergisi, 11(3), 315-330. https://doi.org/10.19159/tutad.1536186.
  55. Demircioğlu, S., Filazi, A. 2010. Detection of Aflatoxin Levels in Red Pepper Produced in Turkey. (Türkiye’de Üretiler Kırmızı Biberlerde Aflatoksin Kalıntılarının Araştırılması). Veteriner Hekimler Derneği Dergisi, 81(2), 63-66.
  56. Dağaşan, Ö., Özen, N. 2011. Aflatoxin, heavy metal and pesticide residue contents of some compound feeds produced in Turkey. (Türkiye’de üretilen bazı karma yemlerin aflatoksin, ağır metal ve pestisid kalıntı düzeyleri). Akdeniz University Journal of the Faculty of Agriculture, 24(1), 9-13.