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Journals / Fırat Tıp Dergisi / 2018 / Cilt: 23 - Sayı: 4

The Significance of Serum Zinc, Copper and Ceruloplasmin in Pregnancy Complications

Gebelik Komplikasyonlarında Serum Çinko, Bakır ve Serüloplazminin Önemi

Habibe DURMUŞOĞLU
ÖZGE TUĞÇE PAŞAOĞLU
Bayram ŞENLİK
NURAY BOZKURT
BÜLENT ÇELİK
HATİCE PAŞAOĞLU
Pages
158–163
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: These results suggest that serum copper and ceruloplasmin oxidase parameters might be important for both preeclampsia and missed abortion, and further far-reaching studies are needed to be conducted on this subject.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: In our study, serum zinc and copper levels, and ceruloplasmin oxidase activity were investigated in two of the pregnancy complications; preeclampsia and missed abortion.
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Key Findings & Data:Material and Method: For this purpose, serum zinc, copper and ceruloplasmin oxidase activity levels of the patients diagnosed with frequently seen pregnancy complications preeclampsia (n =10) and missed abortion (n =20) were compared with healthy pregnant women (n =10 and n =20, respecti-vely) of corresponding weeks.
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Conclusion & Impact:Conclusion: These results suggest that serum copper and ceruloplasmin oxidase parameters might be important for both preeclampsia and missed abortion, and further far-reaching studies are needed to be conducted on this subject.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: In our study, serum zinc and copper levels, and ceruloplasmin oxidase activity were investigated in two of the pregnancy complications; preeclampsia and missed abortion. Material and Method: For this purpose, serum zinc, copper and ceruloplasmin oxidase activity levels of the patients diagnosed with frequently seen pregnancy complications preeclampsia (n =10) and missed abortion (n =20) were compared with healthy pregnant women (n =10 and n =20, respecti-vely) of corresponding weeks. Serum zinc and copper levels were measured using atomic absorption spectroscopy. Ceruloplasmin oxidase activity was determined spectrophotometrically. Results: In the preeclampsia group, zinc levels were found to be diminished compared with controls, however this difference was not statistically significant. Serum copper and ceruloplasmin oxidase activity were detected to be increased (p <0.05). While no significant difference in serum zinc levels of patients diagnosed with missed abortion compared with control group was found, there was a decrease in serum copper levels and cerulop-lasmin oxidase activity (p <0.05). A positive correlation was present between ceruloplasmin activities and copper levels of all groups (for preeklamp-sia r =0,869 p <0,001 and for missed abortion r =0,902 p <0,001). Conclusion: These results suggest that serum copper and ceruloplasmin oxidase parameters might be important for both preeclampsia and missed abortion, and further far-reaching studies are needed to be conducted on this subject.

Özet

Amaç: Çalışmamızda gebelik komplikasyonlarından preeklampsi ve missed abortusta serum çinko ve bakır seviyeleri ile serüloplazmin oksidaz aktivitesi incelendi. Gereç ve Yöntem: Bu amaçla gebelik komplikasyonlarından sık görülen preeklampsi (n =10) ve missed abortus tanılı hastaların (n=20) serum çinko, bakır, serüloplazmin değerleri, aynı haftalardaki sağlıklı gebelerle (sırasıyla n =10, n =20), karşılaştırıldı. Serum çinko ve bakır düzeyleri atomik absorpsiyon spektrofotometre yöntemi ile ölçüldü. Serüloplazmin oksidaz aktivitesi ise spektrofotometrik olarak belirlendi. Bulgular: Preeklampsi grubunda çinko düzeyinde kontrollere göre düşme görüldü, ancak istatistik anlamlı bir fark gözlenmedi. Serum bakır düzeyi ve serüloplazmin oksidaz aktivitesinde artış olduğu tespit edildi (p <0,05). Missed abortus tanılı hastalarda ise sağlıklı kontrol gebelere göre serum çinko düzeylerinde anlamlı fark bulunamazken, serum bakır düzeyi ve seruloplazmin oksidaz aktivitesinde azalma olduğu tespit edildi (p <0,05).Tüm grupların serüloplazmin oksidaz aktiviteleri ile bakır düzeyleri arasında ise pozitif korelasyon vardı (Preeklampsi için; r =0,869 p <0,001 ve missed abortus için r =0,902 p <0,001). Sonuç: Bu sonuçlar, gerek preeklampsi gerekse missed abortus için bakır ve serüloplazmin oksidaz parametrelerinin önemli olabileceğini ve bu konuda daha geniş kapsamlı çalışmalar yapılması gerektiğini göstermektedir.

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Cite This Article

DURMUŞOĞLU, H., PAŞAOĞLU, Ö. T., ŞENLİK, B., BOZKURT, N., ÇELİK, B., PAŞAOĞLU, H. (2018). The Significance of Serum Zinc, Copper and Ceruloplasmin in Pregnancy Complications. Fırat Tıp Dergisi, Cilt: 23 - Sayı: 4, 158–163. https://ajindex.com/articles/165998

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