Journals / Çocuk Enfeksiyon Dergisi / 2017 / Cilt: 11 - Sayı: 3

Assessment of Platelet Parameters in Children with Pneumonia

Pnömonili Çocuklarda Trombosit Parametrelerinin Değerlendirilmesi

Pages
122–128
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies are required to confirm whether platelet volume parameters are decisive laboratory parameters for the follow-up of pneumonia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study is to compare the platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrits (PCT) of patients with pneumonia with those of healthy controls, and to investigate the correlation of the disease with other laboratory parameters.
📊
Key Findings & Data:Material and Methods: One hundred and ninety child patients with pneumonia and 71 healthy children were included in the study and their platelet parameters were compared, with correlations examined between the clinical and laboratory parameters of patients with pneumonia and platelet parameters.
💡
Conclusion & Impact:Further studies are required to confirm whether platelet volume parameters are decisive laboratory parameters for the follow-up of pneumonia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study is to compare the platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrits (PCT) of patients with pneumonia with those of healthy controls, and to investigate the correlation of the disease with other laboratory parameters. Material and Methods: One hundred and ninety child patients with pneumonia and 71 healthy children were included in the study and their platelet parameters were compared, with correlations examined between the clinical and laboratory parameters of patients with pneumonia and platelet parameters. The data analysis was carried out using the SPSS for Windows version 15.0 program Results: No significant difference was observed between the groups in terms of age or gender, while the leucocyte, platelet count and PCT of the patients with pneumonia was statistically significantly higher in the patient group than in the control group (p< 0.05). The MPV and PDW values of the patients with pneumonia were statistically significantly lower than those of the control group (p< 0.05). In the pneumonia and control groups, MPV was found to be significantly positively correlated with age and hemoglobin, but had a significant negative correlation with platelet count (pneumonia group p= 0.046, p= 0.008, p< 0.001; control group p= 0.002, p= 0.019, p= 0.003, respectively). In the pneumonia group, PDW was found to have a significant positive correlation with leucocyte and hemoglobin, and a significant negative correlation with platelet (p= 0.006, p= 0.018 p< 0.001, respectively). On the other hand, PCT was identified to have a statistically significant positive correlation only with platelet (p< 0.001). The patients were divided into two groups based on hospitalization duration. No significant difference was observed in the platelets parameters of the two groups. Conclusion: Significant differences were identified between the patients with pneumonia and the healthy controls in terms of platelet parameters. Further studies are required to confirm whether platelet volume parameters are decisive laboratory parameters for the follow-up of pneumonia.

Özet

Giriş: Çalışmamızda pnömoni tanısı ile izlenen hastaların trombosit, ortalama trombosit hacmi (MPV), trombosit dağılım aralığı (PDW), plateletcrit (PCT) değerlerinin sağlıklı kontrol grubuyla karşılaştı-rılması ve ayrıca yatış sürelerine ve komplikasyon gelişmesine göre farklılık gösterip göstermediğinin belirlenmesi amaçlandı. Gereç ve Yöntemler: Çalışmaya 190 pnömoni hastası ile 71 sağlıklı çocuk alındı. Gruplar trombosit parametreleri yönünden karşılaştırıldı. Pnömonili olguların klinik ve laboratuvar bulguları ile trombosit para-metreleri arasındaki ilişki incelendi. Verilerin analizi SPSS for Windows 15.0 programında yapıldı. Bulgular: Gruplar arasında yaş ve cinsiyet açısından anlamlı farklılık yoktu. Hasta grupta lökosit, trombosit sayısı ve PCT ortalaması kontrol grubuna göre istatistiksel olarak anlamlı yüksek bulunurken (p< 0.05) MPV ve PDW ortalaması anlamlı olarak düşüktü (p< 0.05). MPV hasta ve kontrol grubunda yaş ve hemoglobin ile pozitif yönde trombosit sayısı ile negatif yönde (hasta grubunda p= 0.046, p= 0.008 p< 0.001; kontrol grubunda p= 0.002, p= 0.019, p= 0.003, sırası ile) istatistiksel olarak an-lamlı ilişkiliydi. PDW hastalarda lökosit ve hemoglobin ile pozitif yönde trombosit ile negatif yönde (p= 0.006, p= 0.018 p< 0.001 sırası ile) ista-tistiksel olarak anlamlı ilişkiliydi. PCT trombosit ile çok iyi derecede po-zitif yönde (p< 0.001) istatistiksel olarak anlamlı ilişkili bulundu. Olgular hastanede yatış sürelerine göre 14 gün ve altı ve 14 gün üstü yatanlar olarak iki gruba ayrıldı. Gruplar arasında trombosit parametreleri açısın-dan anlamlı farklılık gözlenmedi. Sonuç: Çalışmamızda trombosit parametreleri; pnömonili hastalarda sağlam çocuklardan anlamlı farklılıklar gösterdi. Pnömonili çocukların izleminde trombosit parametrelerinin belirleyici olup olmayacağını saptamak için konu ile ilgili daha kapsamlı çalışmalar gereklidir.

🔖

Cite This Article

ŞAHİN, M., DURU, H. N. S., ELEVLİ, M., ÇİVİLİBAL, M. (2017). Assessment of Platelet Parameters in Children with Pneumonia. Çocuk Enfeksiyon Dergisi, Cilt: 11 - Sayı: 3, 122–128. https://ajindex.com/articles/164750

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. He C, Kang L, Miao L, et al. Pneumonia Mortality among Children under 5 in China from 1996 to 2013: An Analysis from National Surveillance System. PLoS One 2015;10:e0133620. Elzey BD, Sprague DL, Ratliff TL. The emerging role of platelets in adaptive immunity. Cell Immunol 2005;238:1-9.
  2. Karadag-Oncel E, Ozsurekci Y, Kara A, Karahan S, Cengiz AB, Ceyhan M. The value of mean platelet volume in the determination of community acquired pneumonia in children. Ital J Pediatr 2013;39:16. Türk Toraks Dernegi Cocuklarda Toplumda Gelisen Pnömoni Tanı ve Tedavi Uzlası Raporu 2009. Toraks Dergisi 2009;10(Ek-3) Chen HL, Chiou SS, Sheen JM, Jang RC, Lu CC, Chang TT. Thrombocytosis in children at one medical center of southern Taiwan. Acta Paediatr Taiwan 1999;40:309e13. Indolfi G, Catania P, Bartolini E, et al. Incidence and clinical significance of reactive thrombocytosis in children aged 1 to 24 months, hospitalized for community-acquired infections. Platelets 2008;19:409-14.
  3. Wang JL, Huang LT, Wu KH, Lin HW, Ho MY, Liu HE. Associations of reactive thrombocytosis with clinical characteristics in pediatric diseases. Pediatr Neonatol 2011;52:261-6.
  4. Mirsaeidi M, Peyrani P, Aliberti S, et al. Thrombocytopenia and thrombocytosis at time of hospitalization predict mortality in patients with community-acquired pneumonia. Chest 2010;137:416-20.
  5. Wolach B, Morag H, Drucker M, Sadan N. Thrombocytosis after pneumonia with empyema and other bacterial infections in children. Pediatr Infect Dis J 1990;9:718-21.
  6. Zheng SY, Xiao QY, Xie XH, et al. Association between secondary thrombocytosis and viral respiratory tract infections in children. Sci Rep 2016;6:22964. Kim JK, Jeon JS, Kim JW, Kim GY. Correlation between abnormal platelet count and respiratory viral infection in patients from Cheonan, Korea. J Clin Lab Anal 2016;30:185-9.
  7. Prina E, Ferrer M, Ranzani OT, et al. Thrombocytosis is a marker of poor outcome in community-acquired pneumonia. Chest 2013;143:767-75.
  8. Dodig S, Raos M, Kovac K, et al. Thrombopoietin and interleukin-6 in children with pneumonia-associated thrombocytosis. Arch Med Res 2005;362:124-8. Dow RB. The clinical and laboratory utility of platelet volume parameters. Aust J Med Sci 1994;15:12-5. Rowan RM. Platelet size distribution analysis: principles techniques and potential clinical utility. Hematol Rev 1986;1:109-44.
  9. Kim KY, Kim KE, Kim KH. Mean platelet volume in the normal state and in various clinical disorders. Yonsei Med J 1986;27:219-26.
  10. Uysal P, Tuncel T