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Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2018 / Cilt: 24 - Sayı: 2

Influence of Maternal Toxoplasmosis on the Second-Trimester Aneuploidy Screening Test

Ümit GÖRKEM
Ayşe Semra GÜRESER
Cihan TOĞRUL
Djursun KARASARTOVA
Tayfun GÜNGÖR
Ayşegül Taylan ÖZKAN
Özgür KOÇAK
Pages
71–75
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There was no data regarding the unaffected population whom used for calculation of MoM, if they had toxoplasmosis in their life span.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: With apoptosis being critical for the development and homeostasis of placental tissues, it is possible to hypothesize that accelerated trophoblastic apoptosis during pregnancy may result in a partial loss of trophoblastic activity or trophoblastic cell mass, and ultimately may alter the second-trimester screening test parameters.
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Key Findings & Data:STUDY DESIGN: This retrospective study was conducted with 552 pregnant women admitted to our University Hospital.
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Conclusion & Impact:There was no data regarding the unaffected population whom used for calculation of MoM, if they had toxoplasmosis in their life span.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

OBJECTIVE: With apoptosis being critical for the development and homeostasis of placental tissues, it is possible to hypothesize that accelerated trophoblastic apoptosis during pregnancy may result in a partial loss of trophoblastic activity or trophoblastic cell mass, and ultimately may alter the second-trimester screening test parameters. Thus, this study was conducted to investigate the influence of maternal toxoplasmosis on second-trimester aneuploidy screening tests. STUDY DESIGN: This retrospective study was conducted with 552 pregnant women admitted to our University Hospital. The demographic data such as maternal age and weight; and the main parameters of second-trimester aneuploidy screening test including maternal serum alpha-fetoprotein, unconjugated estriol (uE3) and human chorionic gonadotropin were analyzed with the comparison of their Toxoplasma immunoglobulin serology results. RESULTS: The mean age of the pregnant women was 27.6 (17.0 - 43.0) years, and the mean maternal weight was 65.0 (40.0 - 120.0) kg. The pregnant women with positive Toxoplasma IgG antibody had a higher mean maternal age than those with negative Toxoplasma IgG antibody (p 0.05, for all). CONCLUSION: Although IgG-seropositivity of toxoplasmosis may lead to an accelerated trophoblastic apoptosis during pregnancy, there is no significant influence on the second-trimester screening test results. There was no data regarding the unaffected population whom used for calculation of MoM, if they had toxoplasmosis in their life span.

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Cite This Article

GÖRKEM, Ü., GÜRESER, A. S., TOĞRUL, C., KARASARTOVA, D., GÜNGÖR, T., ÖZKAN, A. T., KOÇAK, Ö. (2018). Influence of Maternal Toxoplasmosis on the Second-Trimester Aneuploidy Screening Test. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 24 - Sayı: 2, 71–75. https://ajindex.com/articles/164691

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