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Journals / Eurasian Dental Research / 2026 / Volume: 3 Issue: 1

The Effects of Hyaluronic Acid Gel on Oral Mucositis in Children Receiving Chemotherapy

Serap Keskin Tunç(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, HAMİDİYE DİŞ HEKİMLİĞİ FAKÜLTESİ, HAMİDİYE DİŞ HEKİMLİĞİ PR.)0000-0001-5439-6598
Yusuf Rodi Mızrak(VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ)0000-0003-4245-3780
Gamze Aksu(VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-6469-1045
Kamuran Karaman(VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-2991-3551
Mahide Büşra Başkan(İSTANBUL ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ, DİŞ HEKİMLİĞİ (DR))0000-0003-1217-5361
Pages
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Publication Date
2025-04-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion The study results show that both standard oral care with sodium bicarbonate and HA gel have similar effects on pain relief and regression of OM in pediatric cancer patients undergoing CT.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim Oral mucositis (OM) is a common side effect of systemic chemotherapy (CT) in cancer patients.
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Key Findings & Data:Material and method A total of 40 pediatric patients aged between 3 and 18 years who were diagnosed with leukemia and treated with CT in the inpatient setting were included.
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Conclusion & Impact:Conclusion The study results show that both standard oral care with sodium bicarbonate and HA gel have similar effects on pain relief and regression of OM in pediatric cancer patients undergoing CT.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Chemotherapy · Childhood leukemia · Hyaluronic acid gel

Abstract

Aim Oral mucositis (OM) is a common side effect of systemic chemotherapy (CT) in cancer patients. The aim of this study was to investigate the effect of hyaluronic acid (HA) gel on OM in children receiving CT. Material and method A total of 40 pediatric patients aged between 3 and 18 years who were diagnosed with leukemia and treated with CT in the inpatient setting were included. The patients were randomly divided into groups. The HA group (n=20) received HA gel and the control group (n=20) received sodium bicarbonate. The grade of OM was evaluated based on the World Health Organization Common Toxicity Criteria Scale. The pain severity was assessed using the Visual Analog Scale (VAS). Results Of the patients, 21 (52.5%) were girls and 19 (47.5%) were boys. The mean age was 9.37±5.11 (range, 3 to 18) years. The majority of the patients (77.5%) had a diagnosis of pro-B-cell acute lymphoblastic leukemia (ALL). There was no statistically significant difference in the number of OM lesions and VAS scores between the groups (p>0.05). Conclusion The study results show that both standard oral care with sodium bicarbonate and HA gel have similar effects on pain relief and regression of OM in pediatric cancer patients undergoing CT. The HA gel is a feasible alternative for the pediatric population.

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Cite This Article

Tunç, S. K., Mızrak, Y. R., Aksu, G., Karaman, K., Başkan, M. B. (2025). The Effects of Hyaluronic Acid Gel on Oral Mucositis in Children Receiving Chemotherapy. Eurasian Dental Research, Volume: 3 Issue: 1. https://doi.org/10.62243/edr.1586384

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