The resulting biodegradable block copolymer polyester was characterized by Fourier transform infrared spectroscopy (FTIR), 1 H nuclear magnetic resonance spectroscopy ( 1 H-NMR), and gel permeation chromatography (GPC).
📌 3 Key Takeaways
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Objective & Hypothesis:In this study, biodegradable polyethylene glycol (PEG)-based block copolymer polyester was synthesized and evaluated by ring-opening polymerization (ROP).
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Key Findings & Data:Poly(ethylene glycol- b -ɛ-caprolactone) [PEG- b -PCL] block copolymer was prepared by ring-opening polymerization of ɛ-caprolactone (ɛ-CL) in the presence of polyethylene glycol (400 Da, 2000 Da, 3000 Da) as an initiator, employing two catalyst systems: dibutyltin dilaurate (DBTDL) and tin (II) 2-ethylhexanoate (Sn(Oct) 2 ).
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Conclusion & Impact:The resulting biodegradable block copolymer polyester was characterized by Fourier transform infrared spectroscopy (FTIR), 1 H nuclear magnetic resonance spectroscopy ( 1 H-NMR), and gel permeation chromatography (GPC).
In this study, biodegradable polyethylene glycol (PEG)-based block copolymer polyester was synthesized and evaluated by ring-opening polymerization (ROP). Poly(ethylene glycol- b -ɛ-caprolactone) [PEG- b -PCL] block copolymer was prepared by ring-opening polymerization of ɛ-caprolactone (ɛ-CL) in the presence of polyethylene glycol (400 Da, 2000 Da, 3000 Da) as an initiator, employing two catalyst systems: dibutyltin dilaurate (DBTDL) and tin (II) 2-ethylhexanoate (Sn(Oct) 2 ). Polymerization was conducted under both dispersion and bulk conditions to investigate the effect of solvent on copolymer molecular weight, dispersity, and polymerization time. The resulting biodegradable block copolymer polyester was characterized by Fourier transform infrared spectroscopy (FTIR), 1 H nuclear magnetic resonance spectroscopy ( 1 H-NMR), and gel permeation chromatography (GPC).
Göktaş, M. (2026). Synthesis and Characterization of Biodegradable Polyester by Ring-Opening Polymerization (ROP) Using Different Catalyst Systems. Sakarya University Journal of Science, Volume: 30 Issue: 4. https://doi.org/10.16984/saufenbilder.1868839
H. Qian, A. R. Wohl, J. T. Crow, C. W. Macosko, and T. R. Hoye, “A strategy for control of ‘random’ copolymerization of lactide and glycolide: Application to synthesis of PEG-b-PLGA block polymers having narrow dispersity,” Macromolecules, vol. 44, no. 18, pp. 7132–7140, Aug. 2011, doi: 10.1021/ma201169z.
J. Meyer, N. E. Göppert, L. M. Stafast, C. Weber, and U. S. Schubert, “Polyesteracetals via TBD-catalyzed ring-opening polymerization,” Macromol. Rapid Commun., vol. 46, no. 18, Art. no. e00273, Jul. 2025, doi: 10.1002/marc.202500273.
D. Y. Wong, S. J. Hollister, P. H. Krebsbach, and C. Nosrat, “Poly(ε-caprolactone) and poly(L-lactic-co-glycolic acid) degradable polymer sponges attenuate astrocyte response and lesion growth in acute traumatic brain injury,” Tissue Eng., vol. 13, no. 10, pp. 2515–2523, Oct. 2007, doi: 10.1089/ten.2006.0440.
M. Dirauf, I. Muljajew, C. Weber, and U. S. Schubert, “Recent advances in degradable synthetic polymers for biomedical applications—Beyond polyesters,” Prog. Polym. Sci., vol. 129, Art. no. 101547, Jun. 2022, doi: 10.1016/j.progpolymsci.2022.101547.
R. Wyrębiak et al., “Exploration of a novel catalytic approach for synthesizing glycolide and ε-caprolactone copolymers and their application as carriers for paclitaxel,” Molecules, vol. 30, no. 11, Art. no. 2318, May 2025, doi: 10.3390/molecules30112318.
B. G. Jastrzembski and A. S. Shah, “Microparticle drug delivery in ophthalmology,” Int. Ophthalmol. Clin., vol. 57, no. 4, pp. 129–136, Fall 2017, doi: 10.1097/IIO.0000000000000193.
J. Cheng, R. Gao, Y. Zhu, and Q. Lin, “Applications of biodegradable materials in food packaging: A review,” Alex. Eng. J., vol. 91, pp. 70–83, Mar. 2024, doi: 10.1016/j.aej.2024.01.080.
M. Bialik, M. Kuras, M. Sobczak, and E. Oledzka, “Biodegradable synthetic polyesters in the technology of controlled dosage forms of antihypertensive drugs—The overview,” Expert Opin. Drug Deliv., vol. 16, no. 9, pp. 953–967, Sep. 2019, doi: 10.1080/17425247.2019.1651716.
D. Wu et al., “Kinetics of Sn(Oct)₂-catalyzed ring opening polymerization of ε-caprolactone,” Macromol. Res., vol. 25, no. 11, pp. 1070–1075, Oct. 2017, doi: 10.1007/s13233-017-5148-z.
D. Bandelli, C. Weber, and U. S. Schubert, “Strontium isopropoxide: A highly active catalyst for the ring-opening polymerization of lactide and various lactones,” Macromol. Rapid Commun., vol. 40, no. 20, Art. no. 1900306, Oct. 2019, doi: 10.1002/marc.201900306.
W. Wang, “Recent advances in the titanium-based catalysts for ring-opening polymerization,” ACS Omega, vol. 9, no. 28, pp. 29983–29993, Jul. 2024, doi: 10.1021/acsomega.4c00048.
J. Torres-Rodríguez et al., “The hidden isodimorphic crystallization of poly(ε-caprolactone-ran-ω-pentadecalactone) copolymers,” Biomacromolecules, vol. 26, no. 5, pp. 3446–3462, May 2025, doi: 10.1021/acs.biomac.5c00075.
R. M. Mohamed and K. Yusoh, “A review on the recent research of polycaprolactone (PCL),” Adv. Mater. Res., vol. 1134, pp. 249–255, Dec. 2015, doi: 10.4028/www.scientific.net/AMR.1134.249.
T. K. Dash and V. B. Konkimalla, “Poly-ε-caprolactone based formulations for drug delivery and tissue engineering: A review,” J. Control. Release, vol. 158, no. 1, pp. 15–33, Feb. 2012, doi: 10.1016/j.jconrel.2011.09.064.
M. Safari et al., “Biodegradable binary blends of poly(butylene succinate) or poly(ε-caprolactone) with poly(butylene succinate-ran-ε-caprolactone) copolymers: Crystallization behavior,” Polymer, vol. 256, Art. no. 125206, Sep. 2022, doi: 10.1016/j.polymer.2022.125206.
R. El Yousfi et al., “Interaction-driven thermodynamic sol-gel mechanisms and gelation behavior of PEG-based multi-branched PCL copolymers toward injectable biodegradable hydrogels,” J. Mol. Liq., vol. 437, Art. no. 128322, Nov. 2025, doi: 10.1016/j.molliq.2025.128322.
Z. Wang, Q. Ye, S. Yu, and B. Akhavan, “Poly ethylene glycol (PEG)-based hydrogels for drug delivery in cancer therapy: A comprehensive review,” Adv. Healthcare Mater., vol. 12, no. 18, Art. no. 2300105, Jul. 2023, doi: 10.1002/adhm.202300105.
N. Di Trani et al., “Long-acting tunable release of amlodipine loaded PEG-PCL micelles for tailored treatment of chronic hypertension,” Nanomedicine, vol. 37, Art. no. 102417, Oct. 2021, doi: 10.1016/j.nano.2021.102417.
N. Guerrouani, A. Mas, and F. Schué, “MgH₂/PEG initiating system for ring opening polymerization of lactone and lactide,” e-Polymers, vol. 10, no. 1, Art. no. 024, 2010, doi: 10.1515/epoly.2010.10.1.224.
A. Kowalski, A. Duda, and S. Penczek, “Mechanism of cyclic ester polymerization initiated with tin(II) octoate. 2. Macromolecules fitted with tin(II) alkoxide species observed directly in MALDI-TOF spectra,” Macromolecules, vol. 33, no. 3, pp. 689–695, Feb. 2000, doi: 10.1021/ma9906940.
A. Kowalski, A. Duda, and S. Penczek, “Kinetics and mechanism of cyclic esters polymerization initiated with tin(II) octoate, 1. Polymerization of ε-caprolactone,” Macromol. Rapid Commun., vol. 19, no. 11, pp. 567–572, Nov. 1998, doi: 10.1002/(SICI)1521-3927(19981101)19:11 3.0.CO;2-T.
M. Göktaş, C. Aykaç, B. Hazer, and R. D. Ashby, “Synthesis of poly(styrene)-g-poly(oleic acid) graft copolymers via reversible addition/fragmentation transfer (RAFT) polymerization using a poly oleic acid macro-RAFT agent,” J. Polym. Environ., vol. 32, pp. 2629–2643, Jun. 2024, doi: 10.1007/s10924-023-03144-x.