SavedAdd your journal

Journals / Journal of AI / 2025 / Volume: 9 Issue: 1

Global Research Trends for Platelet-Rich Plasma: A Science Mapping with Machine Learning Techniques

Tuncay Küme(DOKUZ EYLUL UNIVERSITY)0000-0003-3440-3513
Muhammet Damar(MUGLA UNIVERSITY)0000-0002-3985-3073
Meltem Çetinkaya(DOKUZ EYLUL UNIVERSITY)0009-0007-0858-357X
Melih Takyaci(DOKUZ EYLÜL ÜNİVERSİTESİ)0009-0008-5987-5924
Muhammet Ali Aydın(DOKUZ EYLUL UNIVERSITY, FACULTY OF SCIENCE)0009-0004-7650-8860
Pages
—
Publication Date
2025-12-31
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In recent years, prominent topics in the literature on PRP include PRP – PRF differences, factors affecting healing and tissue repair, in vitro PRP studies, musculoskeletal injuries, wound healing, and dental treatments.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Platelet-Rich Plasma (PRP) is a product prepared from a person's own blood in the form of platelet-enriched plasma and used to stimulate and regulate healing in many areas of medicine.
📊
Key Findings & Data:This study aimed to bibliometrically evaluate articles published in the field of PRP. 5741 articles published on the Web of Science (WoS) Core Collection between 1980 and 2024 were analyzed using text mining and bibliometric methods using machine learning techniques.
💡
Conclusion & Impact:In recent years, prominent topics in the literature on PRP include PRP – PRF differences, factors affecting healing and tissue repair, in vitro PRP studies, musculoskeletal injuries, wound healing, and dental treatments.
🔬Design:Modeling & Simulation
📍Scope:2024 Verileri
⚙️Variables:Platelet-rich plasma · Platelet · Thrombocyte

Abstract

Platelet-Rich Plasma (PRP) is a product prepared from a person's own blood in the form of platelet-enriched plasma and used to stimulate and regulate healing in many areas of medicine. This study aimed to bibliometrically evaluate articles published in the field of PRP. 5741 articles published on the Web of Science (WoS) Core Collection between 1980 and 2024 were analyzed using text mining and bibliometric methods using machine learning techniques. The WoS Reporting Page, the InCites Report Page, the R Bibliyometrix Package Biblioshiny library, the Python Scikit-learn library for LDA Analysis, the VosViewer package, the Microsoft Excel program, the Oracle Database, and the SQL Query language tools were used. Türkiye ranks fourth in research in the relevant field with 378 articles (6.58%), following the USA, China and Italy. 5741 research articles were published in 1432 different journals and a total of 97584 works were cited in these 5741 articles, with a total of 141229 citations for the relevant publications, with an average citation value of 24.60 per article. The top three research areas most frequently associated with articles on PRP are "orthopedics, surgery, dentistry and oral surgery." In recent years, the topics of "orthodontic tooth movement, low-level laser therapy, exosomes, pregnancy, and endometrium" have become prominent. PRP therapy is used in many different areas, including tissue healing, wound healing, pain management, and cartilage repair. A text mining study found that articles in the field were clustered into eight different groups: “PRP therapy and cellular regeneration, orthopedic treatment applications of PRP, the use of PRP in osteoarthritis and joint diseases, the effect of PRP on wound and skin healing, PRP and autologous treatment methods, bone and tissue healing with PRP, the effect of PRP on tissue and wound healing, platelet activation, and the role of PRP in cardiovascular rehabilitation.”. In recent years, prominent topics in the literature on PRP include PRP – PRF differences, factors affecting healing and tissue repair, in vitro PRP studies, musculoskeletal injuries, wound healing, and dental treatments.

🔖

Cite This Article

Küme, T., Damar, M., Çetinkaya, M., Takyaci, M., Aydın, M. A. (2025). Global Research Trends for Platelet-Rich Plasma: A Science Mapping with Machine Learning Techniques. Journal of AI, Volume: 9 Issue: 1. https://doi.org/10.61969/jai.1819178

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (71)

  1. Altuntaş, Z., Gündeşlioğlu, A. Ö., İnce, B., Dadacı, M., & Savacı, N. (2014). Platelet-rich plasma, platelet-poor plasma, platelet-rich fibrin concepts, their biological roles in wound healing and their areas of use in plastic surgery. Turkish Journal of Plastic Reconstructive and Aesthetic Surgery, 22(2), 49-53. https://dergipark.org.tr/en/download/article-file/214480
  2. Arnoczky, SP, & Shebani-Rad, S. (2013). The basic science of platelet-rich plasma (PRP): what clinicians need to know. Sports Medicine and Arthroscopy Review, 21(4), 180-185. https://doi.org/10.1097/JSA.0b013e3182999712
  3. Beitia, M., Delgado, D., Mercader, J., Sánchez, P., López de Dicastillo, L., & Sánchez, M. (2023). Effect of Platelet-Rich Plasma on Cellular Bioactivity in Vitro: More Than Just Platelets. International Journal of Molecular Sciences, 24(6), 5367. https://doi.org/10.3390/ijms24065367
  4. Bertrand-Duchesne, MP, Grenier, D., & Gagnon, G. (2010). Epidermal growth factor released from platelet‐rich plasma promotes endothelial cell proliferation in vitro. Journal of Periodontal Research, 45(1), 87–93. https://doi.org/10.1111/j.1600-0765.2009.01205.x
  5. Borzini, P., & Mazzucco, I. (2007). Platelet-rich plasma (PRP) and platelet derivatives for topical therapy. What is biologically correct? ISBT Science Series, 2(1), 272-281. https://doi.org/10.1111/j.1751-2824.2007.00085.x
  6. Cakin, MC, Ozdemir, B., Kaya-Dagistanli, F., Arkan, H., Bahtiyar, N., Anapali, M.,. & Onaran, I. (2020). Evaluation of in vivo wound healing potential of lipid fraction from activated platelet-rich plasma. Platelets, 31(4), 513-520. https://doi.org/10.1080/09537104.2019.1663805
  7. Carlson, NE, & Roach Jr, RB (2002). Platelet-rich plasma: clinical applications in dentistry. Journal of the American Dental Association, 133(10), 1383-1386. https://doi.org/10.14219/jada.archive.2002.0054
  8. Carter, CA, Jolly, DG, Worden Sr, CE, Hendren, DG, & Kane, CJ (2003). Platelet-rich plasma gel promotes differentiation and regeneration during equine wound healing. Experimental and molecular pathology, 74(3), 244-255. https://doi.org/10.1016/S0014-4800(03)00017-0
  9. Cavallo, C., Filardo, G., Mariani, E., Kon, E., Marcacci, M., Ruiz, MTP,. & Grigolo, B. (2014). Comparison of platelet-rich plasma formulations for cartilage healing: an in vitro study. JBJS, 96(5), 423-429. https://doi.org/10.2106/JBJS.M.00726
  10. Çelik, B., Damar, M., Bilik, O., Özdağoğlu, G., Özdağoğlu, A., & Damar, HT (2023). Scientometric analysis of nursing research on hip fracture: trends, topics, and profiles. Acta Paulista de Enfermagem, 36, eAPE026132. https://doi.org/10.37689/acta-ape/2023AO0261332
  11. Chang, Y., Li, J., Chen, Y., Wei, L., Yang, X., Shi, Y., & Liang, X. (2015). Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcomes during in vitro fertilization. International Journal of Clinical and Experimental Medicine, 8(1), 1286. https://pmc.ncbi.nlm.nih.gov/articles/PMC4358582/
  12. Chen, L., Wu, D., Zhou, L., & Ye, Y. (2022). Platelet-rich plasma promotes diabetic ulcer repair via inhibition of ferroptosis. Annals of Translational Medicine, 10(20), 1121. https://doi.org/10.21037/atm-22-4654
  13. Choi, BH, Zhu, SJ, Kim, BY, Huh, JY, Lee, SH, & Jung, JH (2005). Effect of platelet-rich plasma (PRP) concentration on the viability and proliferation of alveolar bone cells: an in vitro study. International Journal of Oral and Maxillofacial Surgery, 34(4), 420-424. https://doi.org/10.1016/j.ijom.2004.10.018
  14. Damar, M., Damar, HT, Özbiçakcı, Ş., Yaslı, G., Erenay, FS, Özdağoğlu, G., & Pinto, AD (2025a). Mapping the intellectual structure and research hotspots of cancer studies in primary health care: A machine learning-based analysis. Medicine, 104(12), e41749. https://doi.org/10.1097/MD.0000000000041749
  15. Damar, M., Hosseini, B., Pinto, A. D., Aydin, O., & Cali, U. (2025b). Science mapping of COVID-19 contributions in primary health care by OECD countries: A machine learning approach. Digital Health, 11, 20552076251389341. https://doi.org/10.1177/20552076251389341
  16. Damar, M., Köse, H. Ö., Cagle, MN, & Özen, A. (2024). Mapping the Digital Frontier: Bibliometric and Machine Learning Insights into Public Administration Transformation. Journal of Turkish Court of Accounts, (132), 9-41. https://doi.org/10.52836/sayistay.1455036
  17. De Vos, RJ, Weir, A., van Schie, HT, Bierma-Zeinstra, SM, Verhaar, JA, Weinans, H., & Tol, JL (2010). Platelet-rich plasma injection for chronic Achilles tendinopathy: a randomized controlled trial. Jama, 303(2), 144-149. https://doi.org/10.1001/jama.2009.1986
  18. DeLong, JM, Russell, RP, & Mazzocca, AD (2012). Platelet-rich plasma: the PAW classification system. Arthroscopy: The Journal of Arthroscopic and Related Surgery, 28(7), 998-1009. https://doi.org/10.1016/j.arthro.2012.04.148
  19. Ehrenfest, DMD, Andia, I., Zumstein, MA, Zhang, CQ, Pinto, NR, & Bielecki, T. (2014). Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedics and sports medicine: current consensus, clinical implications, and perspectives. Journal of Muscles, Ligaments & Tendons, 4(1), 3. https://pmc.ncbi.nlm.nih.gov/articles/PMC4049647/
  20. Eichler, C., Baucks, C., Uner, J., Pahmeyer, C., Ratiu, D., Gruettner, B.,. & Sıcak, M. (2020). Platelet-Rich Plasma (PRP) in Breast Cancer Patients: Application Analysis of 163 Sentinel Lymph Node Biopsies. Biomed Research International, 2020(1), 3432987. https://doi.org/10.1155/2020/3432987
  21. El-Sharkawy, H., Kantarcı, A., Deady, J., Hasturk, H., Liu, H., Alshahat, M., & Van Dyke, TE (2007). Platelet‐rich plasma: growth factors and pro‐ and anti‐inflammatory properties. Journal of Periodontics, 78(4), 661–669. https://doi.org/10.1902/jop.2007.060302
  22. Eppley, BL, Woodell, JE, & Higgins, J. (2004). Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing. Plastic and Reconstructive Surgery, 114(6), 1502-1508. https://doi.org/10.1097/01.PRS.0000138251.07040.51
  23. Feng, W., Yang, L., Li, J., Chen, Y., & Yao, B. (2024). Bibliometric analysis of trends in platelet-rich plasma application in cosmetic research between 2001 and 2022. Journal of Cosmetic Dermatology, 23(3), 780-793. https://doi.org/10.1111/jocd.16062
  24. Foster, TE, Puskas, BL, Mandelbaum, BR, Gerhardt, MB, & Rodeo, SA (2009). Platelet-rich plasma: from basic science to clinical applications. American Journal of Sports Medicine, 37(11), 2259-2272. https://doi.org/10.1177/0363546509349921
  25. Gaßling, VL, Açil, Y., Springer, IN, Hubert, N., & Wiltfang, J. (2009). Platelet-rich plasma and platelet-rich fibrin in human cell culture. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 108(1), 48-55. https://doi.org/10.1016/j.tripleo.2009.02.007
  26. Giusti, I., Di Francesco, M., D'Ascenzo, S., Palumbo, P., Rughetti, A., Dell'Orso, L.,. & Dolo, V. (2018). Leukocyte depletion does not affect the healing ability of platelet-rich plasma in vitro. Experimental And Therapeutic Medicine, 15(4), 4029-4038. https://doi.org/10.3892/etm.2018.5887
  27. González, M., Arteaga-Vizcaíno, M., Benito, M., & Benito, M. (2012). Application of platelet-rich plasma (PRP) and its derivatives in dental implantology and plastic surgery. Investigación Clínica, 53(4), 408-418. https://ve.scielo.org/pdf/ic/v53n4/art09.pdf
  28. Gökdemir, G. (2014). Mesotherapy and platelet-rich plasma in the treatment of hair loss. Archives of the Turkish Dermatology & Venerology/Turkderm, 48 (Special issue 1), 74-79. https://doi.org/10.4274/turkderm.48.s17
  29. Gupta, AK, & Taylor, D. (2024). Bibliometric analysis of platelet-rich plasma therapy for hair restoration, facial rejuvenation, dental procedures, and gynecological rejuvenation. Skin Appendage Disorders, 1-10. https://doi.org/10.1159/000541528
  30. Hargrave, B., Varghese, F., Barabutis, N., Catravas, J., & Zemlin, C. (2016). Nanosecond pulsed platelet-rich plasma (ns PRP) improves mechanical and electrical cardiac function following myocardial reperfusion injury. Physiological reports, 4(4), e12710. https://doi.org/10.14814/phy2.12710
  31. Kageyama, T., Nanmo, A., Yan, L., Nittami, T., & Fukuda, J. (2020). Effects of platelet-rich plasma on in vitro hair follicle germ preparation for hair regenerative medicine. Journal of Bioscience and Bioengineering, 130(6), 666-671. https://doi.org/10.1016/j.jbiosc.2020.08.005
  32. Kim, TH, Kim, SH, Sándor, GK, & Kim, YD (2014). Comparison of platelet-rich plasma (PRP), platelet-rich fibrin (PRF) and concentrated growth factor (CGF) in rabbit-skull defect healing. Archives of Oral Biology, 59(5), 550-558. https://doi.org/10.1016/j.archoralbio.2014.02.004
  33. Kobayashi, E., Flückiger, L., Fujioka-Kobayashi, M., Sawada, K., Sculean, A., Schaller, B., & Miron, R. J. (2016). Comparative release of growth factors from PRP, PRF, and advanced PRF. Clinical Oral Research, 20, 2353–2360. https://doi.org/10.1007/s00784-016-1719-1
  34. Kon, E., Buda, R., Filardo, G., Di Martino, A., Timoncini, A., Cenacchi, A.,. & Marcacci, M. (2010). Platelet-rich plasma: intra-articular knee injections yielded positive results in degenerative cartilage lesions. Knee Surgery, Sports Traumatology, Arthroscopy, 18, 472-479. https://doi.org/10.1007/s00167-009-0940-8
  35. Lai, H., Chen, G., Zhang, W., Wu, G., & Xia, Z. (2023). Research trends on platelet-rich plasma in wound management from 2002 to 2021: a 20-year bibliometric analysis. International Wound Journal, 20(6), 1882-1892. https://doi.org/10.1111/iwj.14047
  36. Li, T., Ma, Y., Wang, M., Wang, T., Wei, J., Ren, R.,. & Chen, B. (2019). Platelet-rich plasma plays an antibacterial, anti-inflammatory, and cell proliferation-promoting role in an in vitro model for diabetic infected wounds. Infection and Drug Resistance, 297-309. https://doi.org/10.2147/IDR.S186651
  37. Li, X., Gao, J., Zheng, H., Zou, C., Yu, Z., Wu, Z., & Zhang, J. (2023). Review of platelet-rich plasma application for skin and plastic surgery in the past 20 years: A bibliometric analysis. Journal of Cosmetic Dermatology, 22(6), 1852-1862. https://doi.org/10.1111/jocd.15653
  38. Luzo, AC, Fávaro, WJ, Seabra, AB, & Durán, N. (2020). What is the potential use of platelet-rich plasma (PRP) in cancer treatment? A mini-review. Heliyon, 6(3), e03660. https://doi.org/10.1016/j.heliyon.2020.e03660
  39. Malhotra, A., Pelletier, M. H., Yu, Y., & Walsh, W. R. (2013). Can platelet-rich plasma (PRP) improve bone healing? A comparison between theory and experimental results. Archives of Orthopaedic And Trauma Surgery, 133, 153-165. https://doi.org/10.1007/s00402-012-1641-1
  40. Marx, RE (2001). Platelet-rich plasma (PRP): What is PRP and what is not PRP? Implant Dentistry, 10(4), 225-228. https://journals.lww.com/implantdent/fulltext/2001/10000/Platelet_Rich_Plasma__PRP___What_Is_PRP_and_What.2.aspx
  41. Marx, RE, Carlson, ER, Eichstaedt, RM, Schimmele, SR, Strauss, JE, & Georgeff, KR (1998). Platelet-rich plasma: growth factor boost for bone grafts. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 85(6), 638-646. https://doi.org/10.1016/S1079-2104(98)90029-4
  42. Masuki, H., Okudera, T., Watanebe, T., Suzuki, M., Nishiyama, K., Okudera, H.,. & Kawase, T. (2016). Growth factor and proinflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF) and concentrated growth factors (CGF). International Journal of Implant Dentistry, 2, 1-6. https://doi.org/10.1186/s40729-016-0052-4
  43. Mishra, A., & Pavelko, T. (2006). Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. American Journal Of Sports Medicine, 34(11), 1774-1778. https://doi.org/10.1177/0363546506288850
  44. Mishra, A., Woodall Jr, J., & Vieira, A. (2009). Tendon and muscle therapy using platelet-rich plasma. Sports Medicine Clinics, 28(1), 113-125. https://doi.org/10.1016/j.csm.2008.08.007
  45. Orban, YA, Soliman, MA, Hegab, YH, & Alkilany, MM (2022). Autologous platelet-rich plasma vs conventional dressing in the management of chronic diabetic foot ulcers. Wounds: A Compendium of Clinical Research and Practice, 33(2), 36-42. https://doi.org/10.25270/wnds/2022.3642
  46. Otero, L., Carrillo, N., Calvo-Guirado, J.L., Villamil, J., & Delgado-Ruíz, RA (2017). Osteogenic potential of platelet-rich plasma in dental stem cell cultures. British Journal of Oral and Maxillofacial Surgery, 55(7), 697-702. https://doi.org/10.1016/j.bjoms.2017.05.005
  47. Özdağoğlu, G., Özdağoğlu, A., & Damar, M. (2022). The Research Portfolio Of Lean Production From The Web Of Science Filter: Where Should We Start?. Verimlilik Dergisi, (2), 213-230. https://doi.org/10.51551/verimlilik.900359
  48. Patel, S., Dhillon, MS, Aggarwal, S., Marwaha, N., & Jain, A. (2013). Treatment with platelet-rich plasma is more effective than placebo for knee osteoarthritis: a prospective, double-blind, randomized trial. American Journal of Sports Medicine, 41(2), 356-364. https://doi.org/10.1177/0363546512471299
  49. Phoebe, LKW, Lee, KWA, Chan, LKW, Hung, LC, Wu, R., Wong, S.,. & Yi, KH (2024). Use of platelet-rich plasma for skin rejuvenation. Skin Research and Technology, 30(4), e13714. https://doi.org/10.1111/srt.13714
  50. Raeissadat, SA, Karimzadeh, A., Hashemi, M., & Bagherzadeh, L. (2018). Safety and efficacy of platelet-rich plasma in the treatment of carpal tunnel syndrome; a randomized controlled trial. BMC Musculoskeletal Disorders, 19, 1-6. https://doi.org/10.1186/s12891-018-1963-4
  51. Ren, B., Lv, X., Tu, C., & Li, Z. (2021). Research trends of platelet-rich plasma application in orthopedics from 2002 to 2020: a bibliometric analysis. Orthopedics International, 45, 2773–2790. https://doi.org/10.1007/s00264-021-05163-6
  52. Somasundaram, V., Basudhar, D., Bharadwaj, G., No, J.H., Ridnour, LA, Cheng, RY,. & Wink, DA (2019). Molecular mechanisms of nitric oxide in cancer progression, signal transduction, and metabolism. Antioxidants & Redox Signaling, 30(8), 1124-1143. https://doi.org/10.1089/ars.2018.7527
  53. Somoza, RA, Welter, JF, Correa, D., & Caplan, AI (2014). Chondrogenic differentiation of mesenchymal stem cells: challenges and unmet expectations. Tissue Engineering Part B: Reviews, 20(6), 596-608. https://doi.org/10.1089/ten.teb.2013.0771
  54. Stewart, S., Bryant, S.J., Ahn, J., & Hankenson, KD (2015). Bone regeneration. In Translational regenerative medicine (pp. 313–333). Academic Press.
  55. Szwedowski, D., Szczepanek, J., Paczesny, Ł., Zabrzyński, J., Gagat, M., Mobasheri, A., & Jeka, S. (2021). Effect of platelet-rich plasma on the intra-articular microenvironment in knee osteoarthritis. International Journal of Molecular Sciences, 22(11), 5492. https://doi.org/10.3390/ijms22115492
  56. Tozum, TF, & Demiralp, B. (2003). Platelet-rich plasma: a promising innovation in dentistry. Journal-Canadian Dental Association, 69(10), 664-665. https://stage.cda-adc.ca/jadc/vol-69/issue-10/664.pdf
  57. Weibrich, G., Hansen, T., Kleis, W., Buch, R., & Hitzler, W. E. (2004). Effect of platelet concentration in platelet-rich plasma on periimplant bone regeneration. Bone, 34(4), 665-671. https://doi.org/10.1016/j.bone.2003.12.010
  58. Weibrich, G., Kleis, W.K., Hafner, G., & Hitzler, WE (2002). Growth factor levels in platelet-rich plasma and their correlation with donor age, sex, and platelet count. Journal of Cranio-Maxillofacial Surgery, 30(2), 97-102. https://doi.org/10.1054/jcms.2002.0285
  59. Xu, J., Du, W., Xue, X., Chen, M., Zhou, W., & Luo, X. (2023). Global research trends on platelet-rich plasma for tendon and ligament injuries in the past two decades: a bibliometric and visualized study. Frontiers in Surgery, 10, 1113491. https://doi.org/10.3389/fsurg.2023.1113491
  60. Yasli, G., Damar, M., Ozbicakci, S., Alici, S., & Pinto, AD (2024). Primary care research on hypertension: A bibliometric analysis using machine learning. Medicine, 103(47), e40482. https://doi.org/10.1097/MD.0000000000040482
  61. Yıldız, C., & Özgürtaş, T. (2017). Platelet-rich plasma. Journal of the Turkish Orthopaedic and Traumatology Association, 16, 247-258. https://doi.org/10.14292/totbid.dergisi.2017.34
  62. Yiğitarslan, K., Ercan, Ş., Özcan, C., & Özcan, Ü. A. (2018). Platelet-Rich Plasma and Its Applications in Veterinary Medicine. Turkish Clinics Journal of Veterinary Sciences, 9(2), 52-61. https://doi.org/10.5336/vetsci.2018-61362
  63. Cakin, MC, Ozdemir, B., Kaya-Dagistanli, F., Arkan, H., Bahtiyar, N., Anapali, M.,. & Onaran, I. (2020). Evaluation of in vivo wound healing potential of lipid fraction from activated platelet-rich plasma. Platelets, 31(4), 513-520. https://doi.org/10.1080/09537104.2019.1663805
  64. Cavallo, C., Filardo, G., Mariani, E., Kon, E., Marcacci, M., Ruiz, MTP,. & Grigolo, B. (2014). Comparison of platelet-rich plasma formulations for cartilage healing: an in vitro study. JBJS, 96(5), 423-429. https://doi.org/10.2106/JBJS.M.00726
  65. Eichler, C., Baucks, C., Uner, J., Pahmeyer, C., Ratiu, D., Gruettner, B.,. & Sıcak, M. (2020). Platelet-Rich Plasma (PRP) in Breast Cancer Patients: Application Analysis of 163 Sentinel Lymph Node Biopsies. Biomed Research International, 2020(1), 3432987. https://doi.org/10.1155/2020/3432987
  66. Giusti, I., Di Francesco, M., D'Ascenzo, S., Palumbo, P., Rughetti, A., Dell'Orso, L.,. & Dolo, V. (2018). Leukocyte depletion does not affect the healing ability of platelet-rich plasma in vitro. Experimental And Therapeutic Medicine, 15(4), 4029-4038. https://doi.org/10.3892/etm.2018.5887
  67. Kon, E., Buda, R., Filardo, G., Di Martino, A., Timoncini, A., Cenacchi, A.,. & Marcacci, M. (2010). Platelet-rich plasma: intra-articular knee injections yielded positive results in degenerative cartilage lesions. Knee Surgery, Sports Traumatology, Arthroscopy, 18, 472-479. https://doi.org/10.1007/s00167-009-0940-8
  68. Li, T., Ma, Y., Wang, M., Wang, T., Wei, J., Ren, R.,. & Chen, B. (2019). Platelet-rich plasma plays an antibacterial, anti-inflammatory, and cell proliferation-promoting role in an in vitro model for diabetic infected wounds. Infection and Drug Resistance, 297-309. https://doi.org/10.2147/IDR.S186651
  69. Masuki, H., Okudera, T., Watanebe, T., Suzuki, M., Nishiyama, K., Okudera, H.,. & Kawase, T. (2016). Growth factor and proinflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF) and concentrated growth factors (CGF). International Journal of Implant Dentistry, 2, 1-6. https://doi.org/10.1186/s40729-016-0052-4
  70. Phoebe, LKW, Lee, KWA, Chan, LKW, Hung, LC, Wu, R., Wong, S.,. & Yi, KH (2024). Use of platelet-rich plasma for skin rejuvenation. Skin Research and Technology, 30(4), e13714. https://doi.org/10.1111/srt.13714
  71. Somasundaram, V., Basudhar, D., Bharadwaj, G., No, J.H., Ridnour, LA, Cheng, RY,. & Wink, DA (2019). Molecular mechanisms of nitric oxide in cancer progression, signal transduction, and metabolism. Antioxidants & Redox Signaling, 30(8), 1124-1143. https://doi.org/10.1089/ars.2018.7527