Journals / Phoenix Medical Journal / 2026 / Cilt: 8 Sayı: 2

Comparison of the Effects of Low-Flow and High-Flow Sevoflurane Anesthesia on Hemogram Parameters in Patients Undergoing Septorhinoplasty

Septorinoplasti Geçiren Hastalarda Düşük Akım ve Yüksek Akım Sevofluran Anestezisinin Hemogram Parametreleri Üzerine Etkilerinin Karşılaştırılması

Burçin Alaçam(SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ, TIP PR.)0009-0005-6064-8591
Havva Kocayigit(SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8719-7031
Ayça Taş Tuna(SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-6764-2647
Ali Fuat Erdem(SAKARYA ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-6994-3971
Pages
348–353
Publication Date
2026-07-10
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Low-flow sevoflurane anesthesia appears not to have adverse effects when hemogram and hemogram-derived inflammatory parameters are considered, and based on this, we believe that low-flow anesthesia can be regarded as a safe alternative to high-flow anesthesia in terms of inflammation.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Surgical procedures and anesthesia can influence perioperative parameters by triggering a systemic inflammatory response.
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Key Findings & Data:However, the effects of different fresh gas flow strategies applied during anesthesia on these parameters remain unclear.
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Conclusion & Impact:Conclusion: Low-flow sevoflurane anesthesia appears not to have adverse effects when hemogram and hemogram-derived inflammatory parameters are considered, and based on this, we believe that low-flow anesthesia can be regarded as a safe alternative to high-flow anesthesia in terms of inflammation.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Düşük akım anestezi · yüksek akım anestezi · hemogram

Abstract

Objective: Surgical procedures and anesthesia can influence perioperative parameters by triggering a systemic inflammatory response. This condition may also alter perioperative hematological values in individuals. Inflammatory indices calculated from hemogram analysis, such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), have increasingly been used to evaluate perioperative inflammation. However, the effects of different fresh gas flow strategies applied during anesthesia on these parameters remain unclear. Material and Methods: In this retrospective study, the data of 42 ASA I–II patients who underwent septorhinoplasty and received either low-flow (1–2 L/min) or high-flow (2–4 L/min) sevoflurane anesthesia during the operation were analyzed. Preoperative and postoperative 24-hour hemogram parameters and hemogram-derived inflammatory indices were compared between the groups. In addition, perioperative hemodynamic and respiratory parameters were also evaluated. Results: When the demographic characteristics of the patients were examined, no differences were observed between the groups. Hemogram parameters, including NLR, PLR, and SII, did not show significant differences between the low-flow and high-flow anesthesia groups in the preoperative and postoperative evaluations. Although postoperative increases in inflammatory indices tended to be higher in the high-flow group, these differences were not statistically significant. Hemodynamic and respiratory parameters throughout the procedure were also similar between the groups. The findings suggest that low-flow anesthesia does not increase perioperative inflammatory responses compared with high-flow anesthesia and provides comparable physiological stability. Conclusion: Low-flow sevoflurane anesthesia appears not to have adverse effects when hemogram and hemogram-derived inflammatory parameters are considered, and based on this, we believe that low-flow anesthesia can be regarded as a safe alternative to high-flow anesthesia in terms of inflammation.

Özet

Amaç: Cerrahi girişimler ve anestezi, sistemik inflamatuvar yanıtı tetikleyerek perioperatif parametreleri etkileyebilir. Bu durum bireylerde perioperatif hematolojik değerlerde de değişikliklere yol açabilir. Hemogram analizinden elde edilen nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı (PLR) ve sistemik immün-inflamasyon indeksi (SII) gibi inflamatuvar indeksler, perioperatif inflamasyonun değerlendirilmesinde giderek daha fazla kullanılmaktadır. Ancak anestezi sırasında uygulanan farklı taze gaz akım stratejilerinin bu parametreler üzerindeki etkileri net olarak bilinmemektedir. Gereç ve Yöntem: Bu retrospektif çalışmada, septorinoplasti geçiren ve operasyon sırasında düşük akım (1–2 L/dk) veya yüksek akım (2–4 L/dk) sevofluran anestezisi uygulanan ASA I–II sınıfındaki 42 hastanın verileri analiz edildi. Gruplar arasında preoperatif ve postoperatif 24. saat hemogram parametreleri ile hemogramdan türetilen inflamatuvar indeksler karşılaştırıldı. Ayrıca perioperatif hemodinamik ve solunumsal parametreler de değerlendirildi. Bulgular: Hastaların demografik özellikleri incelendiğinde gruplar arasında anlamlı fark saptanmadı. NLR, PLR ve SII dahil olmak üzere hemogram parametreleri açısından preoperatif ve postoperatif değerlendirmelerde düşük akım ve yüksek akım anestezi grupları arasında anlamlı fark bulunmadı. Postoperatif inflamatuvar indekslerdeki artış yüksek akım grubunda daha fazla eğilim göstermesine rağmen bu fark istatistiksel olarak anlamlı değildi. İşlem süresince hemodinamik ve solunumsal parametreler de gruplar arasında benzer bulundu. Bulgular, düşük akım anestezinin yüksek akım anesteziye kıyasla perioperatif inflamatuvar yanıtı artırmadığını ve benzer fizyolojik stabilite sağladığını göstermektedir. Sonuç: Hemogram ve hemogramdan türetilen inflamatuvar parametreler açısından değerlendirildiğinde, düşük akım sevofluran anestezisinin olumsuz bir etkisi olmadığı görülmektedir. Bu bulgular doğrultusunda, düşük akım anestezinin inflamasyon açısından yüksek akım anesteziye güvenli bir alternatif olarak değerlendirilebileceği düşünülmektedir.

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Cite This Article

Alaçam, B., Kocayigit, H., Tuna, A. T., Erdem, A. F. (2026). Comparison of the Effects of Low-Flow and High-Flow Sevoflurane Anesthesia on Hemogram Parameters in Patients Undergoing Septorhinoplasty. Phoenix Medical Journal, Cilt: 8 Sayı: 2, 348–353. https://doi.org/10.38175/phnx.1953958

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