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Journals / Interdisciplinary Medical Journal / 2026 / Volume: 14 Issue: 48

Evaluation of serum adipocytokine and interleukin-18 levels in patients with epilepsy

Ahmet Dündar(Mardin Artuklu University, Vocational School of Health Services, Department of Medical Services and Techniques, Mardin, Türkiye)0000-0003-0527-189X
Derya Kılınç(Mardin Artuklu University, Graduate Education Institute, Department of Biology, Mardin, Türkiye)0000-0002-2905-6636
Ahmet Yılmaz(Dicle University, Faculty of Medicine, Department of Family Medicine, Diyarbakır, Türkiye)0000-0002-2648-2824
Vugar Jafar(Istinye University, Faculty of Medicine, Department of Neurology, İstanbul, Türkiye)0000-0001-5384-3464
Orhan Ayan(Bozo Özdemir Family Health Center, Batman, Türkiye)0000-0003-4009-1157
Mehmet Uğur Çevik(Dicle University, Faculty of Medicine, Department of Neurology, Diyarbakır, Türkiye)0000-0003-0861-8588
Hamza Aslanhan(Nova Public Health and Safety Unit, Diyarbakır, Türkiye)0000-0002-0904-3811
Pages
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Publication Date
2023-04-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found that the body mass index (BMI) ratio of epilepsy patients who received antiepileptic treatment decreased and was significant compared to the control group and the group that did not receive treatment (p<0.01).

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Epilepsy is a neurological disease characterized by recurrent seizures.
📊
Key Findings & Data:Our aim is to investigate the relationship between serum adipocytokine and interleukin (IL)-18 levels in epilepsy patients receiving and not receiving antiepileptic therapy.
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Conclusion & Impact:It was found that the body mass index (BMI) ratio of epilepsy patients who received antiepileptic treatment decreased and was significant compared to the control group and the group that did not receive treatment (p<0.01).
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Topiramate · Interleukin-18 · Adipocytokine

Abstract

Objective: Epilepsy is a neurological disease characterized by recurrent seizures. The underlying pathophysiological mechanisms in epilepsy are not fully known. Our aim is to investigate the relationship between serum adipocytokine and interleukin (IL)-18 levels in epilepsy patients receiving and not receiving antiepileptic therapy. Method: Our study was established as three groups. I: Epilepsy patients receiving antiepileptic therapy (n=30), II: Newly diagnosed epilepsy patients (n=30) and III: Control group (n=30). Serum adipocytokine and IL-18 levels were measured by enzyme-linked immunoassorbent assay method. Results: It was determined that serum adipocytokine and IL-18 levels were increased in epilepsy patients who received topiramate treatment and did not receive antiepileptic therapy compared to the control group. Serum glucose, total protein, cholesterol and albumin concentrations of patients who received antiepileptic treatment were decreased compared to the control group (p 0.05). It was found that the body mass index (BMI) ratio of epilepsy patients who received antiepileptic treatment decreased and was significant compared to the control group and the group that did not receive treatment (p<0.01). Conclusion: In our study, it was shown that serum adipocytokine and IL-18 levels were increased in epilepsy patients who received and did not receive antiepileptic therapy. Findings from this study suggest that adipocytokine and IL-18 may be useful markers for the inflammatory process of epileptogenesis.

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Cite This Article

Dündar, A., Kılınç, D., Yılmaz, A., Jafar, V., Ayan, O., Çevik, M. U., Aslanhan, H. (2023). Evaluation of serum adipocytokine and interleukin-18 levels in patients with epilepsy. Interdisciplinary Medical Journal, Volume: 14 Issue: 48. https://doi.org/10.17944/interdiscip.1285784

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