SavedAdd your journal

Journals / Interdisciplinary Medical Journal / 2026 / Volume: 16 Issue: 54

Adiponectin and Lone atrial fibrillation

Özden Kutlay(AFYONKARAHISAR HEALTH SCIENCES UNIVERSITY)0000-0001-5509-6650
Arzu Keskin Aktan(AFYONKARAHISAR HEALTH SCIENCES UNIVERSITY)0000-0002-2878-0841
Zafer Yalım(AFYONKARAHISAR HEALTH SCIENCES UNIVERSITY)0000-0001-7736-0205
Pages
—
Publication Date
2025-04-12
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results indicated that low adiponectin levels are associated with Lone Atrial Fibrillation and that this relationship persists in patients with secondary Atrial Fibrillation.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Lone atrial fibrillation is an idiopathic arrhythmia seen in younger individuals without any secondary disease.
📊
Key Findings & Data:Adiponectin is an endogenous adipocytokine that increases insulin sensitivity with anti-inflammatory and anti-proliferative effects.
💡
Conclusion & Impact:Our results indicated that low adiponectin levels are associated with Lone Atrial Fibrillation and that this relationship persists in patients with secondary Atrial Fibrillation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Atrial fibrillation · Lone atrial fibrillation · adiponectin

Abstract

Objective: Lone atrial fibrillation is an idiopathic arrhythmia seen in younger individuals without any secondary disease. Adiponectin is an endogenous adipocytokine that increases insulin sensitivity with anti-inflammatory and anti-proliferative effects. Although the relationship between circulating adiponectin and atrial fibrillation has been suggested, it is questionable whether this relationship is arrhythmia-related. Therefore, the focus of this study is to investigate the relationship between adiponectin and Lone atrial fibrillation. Methods: In this prospective study, 26 healthy individuals in sinus rhythm, 34 patients with Lone Atrial Fibrillation, and 38 patients diagnosed with Atrial Fibrillation were included by questioning their cardiovascular histories and risk factors upon their arrival at the hospital. Echocardiography was performed to evaluate the left ventricular ejection fraction. Plasma adiponectin levels were studied with Enzyme-Linked ImmunoSorbent Assay (ELISA). Results: Plasma adiponectin levels were significantly lower in the Atrial Fibrillation and Lone Atrial Fibrillation groups compared to the control group (p<0.001, p<0.001). Adiponectin levels did not differ significantly between Atrial Fibrillation and Lone Atrial Fibrillation groups (p=0.191). Furthermore, adiponectin was positively correlated with left ventricular ejection fraction (r=0.208, p=0.04). Conclusion: This study reveals, for the first time, the relationship between plasma adiponectin levels and Lone Atrial Fibrillation. Our results indicated that low adiponectin levels are associated with Lone Atrial Fibrillation and that this relationship persists in patients with secondary Atrial Fibrillation. Therefore, we predict that adiponectin decreases in Atrial Fibrillation due to arrhythmia independent of secondary diseases.

🔖

Cite This Article

Kutlay, Ö., Aktan, A. K., Yalım, Z. (2025). Adiponectin and Lone atrial fibrillation. Interdisciplinary Medical Journal, Volume: 16 Issue: 54. https://doi.org/10.17944/interdiscip.1467199

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (20)

  1. Sawano M. Lone Atrial Fibrillation Reconfirmed as Unfavorable Arrhythmia. J Atheroscler Thromb. 2021;28(3):225-6. doi: 10.5551/jat.ED137. https://doi.org/10.5551/jat.ED137
  2. Roston TM, Islam S, Hawkins NM, et al. A Population-Based Study of Unexplained/Lone Atrial Fibrillation: Temporal Trends, Management, and Outcomes. CJC Open. 2021;4(1):65-74. https://doi.org/10.1016/j.cjco.2021.09.006
  3. Potpara TS, Lip GHY. Lone atrial fibrillation: what is known and what is to come. Int J Clin Pract. 2011;65(4):446-57. https://doi.org/10.1111/j.1742-1241.2010.02618.x
  4. Zoni-Berisso M, Lercari F, Carazza T, et al. Epidemiology of atrial fibrillation: European perspective. Clin Epidemiol. 2014;6:213-20. doi: 10.2147/CLEP.S47385. Available from: https://doi.org/10.2147/CLEP.S47385
  5. Frost L, Anderson LV, Godtfredsen J, et al. Age and risk of stroke in atrial fibrillation. Neuroepidemiology. 2007;28(2):109-15. https://doi.org/10.1159/000101509
  6. Yamaguchi N, Okumura Y, Watanabe I, et al. Clinical implications of serum adiponectin on progression of atrial fibrillation. JArrhythm. 2017;33(6):608-12. https://doi.org/10.1016/j.joa.2017.07.009
  7. Barnett AS, Piccini JP. Adiponectin: an accurate biomarker for patients at risk for atrial fibrillation? Heart. 2015;101(17):1351-2. https://doi.org/10.1136/heartjnl-2015-307816
  8. Shimano M, Shibata R, Tsuji Y, et al. Circulating Adiponectin Levels in Patients With Atrial Fibrillation. Circ J. 2008;72(7):1120-4. https://doi.org/10.1253/circj.72.1120
  9. Zhu T, Wang Z, Wang S, et al. Association between Serum Adiponectin and Atrial Fibrillation: A Case-Control Study Stratified by Age and Gender. Cardiol Res Pract. 2021;2021:6633948. https://doi.org/10.1155/2021/6633948
  10. Guo Y, Liu L, Wang J. Adiponectin and the risk of new-onset atrial fibrillation: a meta-analysis of prospective cohort studies. Biosci Rep. 2019;39(6):BSR20182284. https://doi.org/10.1042/BSR20182284
  11. Lin K, Marine JE, Calkins H, et al. Should we abandon the term “lone atrial fibrillation”? Hellenic J Cardiol. 2019;60(4):216-23. https://doi.org/10.1016/j.hjc.2019.04.005
  12. Hernández-Romero D, Jover E, Marín F, et al. The prognostic role of adiponectin levels in atrial fibrillation. Eur J Clin Invest. 2013;43(2):168-73. https://doi.org/10.1111/eci.12028
  13. Assar O. Low adiponectin level may contribute to higher incidence of post-cardiac surgery atrial fibrillation in obese patients. Ann Thorac Surg. 2012;93(5):1762-3. https://doi.org/10.1016/j.athoracsur.2011.09.025
  14. Choi BJ, Heo JH, Choi IS, et al. Hypoadiponectinemia in patients with paroxysmal atrial fibrillation. Korean Circ J. 2012;42(10):668-73. https://doi.org/10.4070/kcj.2012.42.10.668
  15. Ybarra J, Resmini E, Planas F, et al. Relationship between adiponectin and left atrium size in uncomplicated obese patients: adiponectin, a link between fat and heart. Obes Surg. 2009;19(9):1324-32. https://doi.org/10.1007/s11695-009-9924-5
  16. Wijesurendra RS, Liu A, Eichhorn C, et al. Lone Atrial Fibrillation Is Associated With Impaired Left Ventricular Energetics That Persists Despite Successful Catheter Ablation. Circulation.2016;134(15):1068-81. https://doi.org/10.1161/CIRCULATIONAHA.116.024679
  17. Thamilarasan M, Grimm RA, Rodriguez LL, et al. Left ventricular diastolic dysfunction in lone atrial fibrillation determined by Doppler tissue imaging of mitral annular motion. Am J Cardiol. 2000;86(9):1026-9, A10. https://doi.org/10.1016/s0002-9149(00)01144-9
  18. Pahlavani HA. Exercise Therapy for People With Sarcopenic Obesity: Myokines and Adipokines as Effective Actors. Front Endocrinol (Lausanne). 2022;13:811751. https://doi.org/10.3389/fendo.2022.811751
  19. Ermakov S, Azarbal F, Stefanick ML, et al. The associations of leptin, adiponectin, and resistin with incident atrial fibrillation in women. Heart. 2016;102(17):1354-62. https://doi.org/10.1136/heartjnl-2015-308927
  20. El-Assaad I, Al-Kindi SG, Saarel EV, et al. Lone Pediatric Atrial Fibrillation in the United States: Analysis of Over 1500 Cases. Pediatr Cardiol. 2017;38(5):1004-9. https://doi.org/10.1007/s00246-017-1608-7