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Journals / Interdisciplinary Medical Journal / 2026 / Volume: 17 Issue: 57

Effect of preoperative intravenous iron therapy on transfusion requirements and morbidity in adult patients undergoing open heart surgery

İbrahim Demir(ISTANBUL MEDIPOL UNIVERSITY)0000-0003-3813-922X
Özlem Turhan(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0000-0003-2127-8135
Türkan Tansel(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0000-0003-3069-777X
Ufuk Alpagut(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0000-0001-6052-2773
Onur Selçuk Göksel(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE)0000-0001-8103-3709
Pages
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Publication Date
2026-04-16
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Larger randomized controlled trials are required to confirm efficacy.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: This study compared postoperative transfusion requirements, morbidity and mortality between adult cardiac surgery patients with preoperative anemia treated with intravenous ferric carboxymaltose and non-anemic patients.
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Key Findings & Data:Methods: This was a prospective study including 95 patients undergoing elective open heart surgery with cardiopulmonary bypass between April 2019 and April 2022.
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Conclusion & Impact:Larger randomized controlled trials are required to confirm efficacy.
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:Transfusion · Open Heart Surgery · Anemia

Abstract

Objective: This study compared postoperative transfusion requirements, morbidity and mortality between adult cardiac surgery patients with preoperative anemia treated with intravenous ferric carboxymaltose and non-anemic patients. Methods: This was a prospective study including 95 patients undergoing elective open heart surgery with cardiopulmonary bypass between April 2019 and April 2022. Twenty-five (26.3%) patients had preoperative iron deficiency anemia and received intravenous ferric carboxymaltose (1000 mg, with an additional 500 mg if indicated preoperatively based on BMI). Seventy patients were non-anemic controls. Transfusion criteria were based on hemoglobin 0.05). The mean operation time was shorter in the anemic treated group, partly reflecting a lower CABG rate. Baseline demographics were similar across groups (mean age 61.6 ± 11.0 vs 60.2 ± 15.9 years). Conclusion: Preoperative intravenous iron therapy in anemic patients did not reduce postoperative transfusion needs but allowed outcomes comparable to non-anemic patients. Intravenous (IV) iron therapy was safe, and patients experienced similar ICU and hospital courses. Larger randomized controlled trials are required to confirm efficacy.

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Cite This Article

Demir, İ., Turhan, Ö., Tansel, T., Alpagut, U., Göksel, O. S. (2026). Effect of preoperative intravenous iron therapy on transfusion requirements and morbidity in adult patients undergoing open heart surgery. Interdisciplinary Medical Journal, Volume: 17 Issue: 57. https://doi.org/10.17944/interdiscip.1798695

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References (16)

  1. DeLoughery TG. Iron Deficiency Anemia. Med Clin North Am. 2017;101(2):319-332. doi: 10.1016/j.mcna.2016.09.004. Epub 2016 Dec 8.
  2. Bellakhal S, Ouertani S, Antit S, Abdelaali I, Teyeb Z, Dougui MH. Iron deficiency anemia: clinical and etiological features. Tunis Med. 2019;97(12):1389-1398.
  3. Hubert M, Gaudriot B, Biedermann S, Gouezec H, Sylvestre E, Bouzille G, Verhoye JP, Flecher E, Ecoffey C. Impact of Preoperative Iron Deficiency on Blood Transfusion in Elective Cardiac Surgery. J Cardiothorac Vasc Anesth. 2019;33(8):2141-2150. doi: 10.1053/j.jvca.2019.02.006.
  4. Scott BH, Seifert FC, Glass PS, Grimson R. Blood use in patients undergoing coronary artery bypass surgery: impact of cardiopulmonary bypass pump, hematocrit, gender, age, and body weight. Anesthesia & Analgesia. 2003;97(4):958-63. https://doi.org/10.1213/01.ANE.0000081790.75298.D8
  5. Horvath KA, Acker MA, Chang H, Bagiella E, Smith PK, Iribarne A, et al. Blood transfusion and infection after cardiac surgery. Ann Thorac Surg. 2013;95(6):2194-201. doi: 10.1016/j.athoracsur.2012.11.078. E
  6. Koch CG, Li L, Duncan AI, Mihaljevic T, Cosgrove DM, Loop FD, et al. Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting. Crit Care Med. 2006;34(6):1608-16. doi: 10.1097/01.CCM.0000217920.48559.D8.
  7. Licker M, Ellenberger C, Sierra J, Christenson J, Diaper J, Morel D. Cardiovascular response to acute normovolemic hemodilution in patients with coronary artery diseases: Assessment with transesophageal echocardiography. Crit Care Med. 2005;33(3):591-7. doi: 10.1097/01.ccm.0000156446.03285.e0.
  8. Loor G, Li L, Sabik JF 3rd, Rajeswaran J, Blackstone EH, Koch CG. Nadir hematocrit during cardiopulmonary bypass: end-organ dysfunction and mortality. J Thorac Cardiovasc Surg. 2012;144(3):654-662.e4. doi: 10.1016/j.jtcvs.2012.03.058.
  9. Ranucci M, Conti D, Castelvecchio S, Menicanti L, Frigiola A, Ballotta A, et al. Hematocrit on cardiopulmonary bypass and outcome after coronary surgery in nontransfused patients. Ann Thorac Surg. 2010;89(1):11-7. doi: 10.1016/j.athoracsur.2009.07.078.
  10. Swaminathan M, Phillips-Bute BG, Conlon PJ, Smith PK, Newman MF, Stafford-Smith M. The association of lowest hematocrit during cardiopulmonary bypass with acute renal injury after coronary artery bypass surgery. Ann Thorac Surg. 2003;76(3):784-91; discussion 792. doi: 10.1016/s0003-4975(03)00558-7.
  11. Murphy GJ, Reeves BC, Rogers CA, Rizvi SI, Culliford L, Angelini GD. Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery. Circulation. 2007;116(22):2544-52. doi: 10.1161/CIRCULATIONAHA.107.698977.
  12. Roman MA, Abbasciano RG, Pathak S, Oo S, Yusoff S, Wozniak M, et al. Patient blood management interventions do not lead to important clinical benefits or cost-effectiveness for major surgery: a network meta-analysis. Br J Anaesth. 2021;126(1):149-156. doi: 10.1016/j.bja.2020.04.087.
  13. Günaydın S, Spahn DR, Özışık K, Demir A, Aşkın G, Sert DE, et al. Building a patient blood management program in a large-volume tertiary hospital setting: Problems and solutions. Turk Gogus Kalp Damar Cerrahisi Derg. 2020;28(3):560-569. doi: 10.5606/tgkdc.dergisi.2020.19701.
  14. Tatar M, Alkış N, Yıldırım Güçlü Ç, Bermede O, Erdemli B, Günaydın S. Cost-Effectiveness and Budget Impact of Comprehensive Anemia Management, The First Pillar of Patient Blood Management, on the Turkish Healthcare System. Clinicoecon Outcomes Res. 2022;14:415-426. doi: 10.2147/CEOR.S360944.
  15. Özhan A, Akgül E, Parlar Aİ, Çekirdekçi A. The association of blood transfusion and acute kidney injury in diabetic coronary artery bypass grafting patients. Cardiovasc Surg Int. 2021;8(1):13-19. doi: 10.5606/e-cvsi.2021.1065.
  16. Köseoğlu FD, Daylan A, Rahman ÖF, Cansu D, Metehan EO, Bozok Ş. Short-term preoperative intravenous iron replacement: Impact on surgical outcomes in cardiovascular disease. Cardiovasc Surg Int. 2024;11(1):42-51. doi: 10.5606/e-cvsi.2024.1635.