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Journals / Acıbadem Üniversitesi Sağlık Bilimleri Dergisi / 2015 / Sayı: 1

An Overview To Cytokeratin Pattern of Cholesteatoma

KOLESTEATOMADA SİTOKERATİN PATERNİNE GENEL BİR BAKIŞ

Ahmet KOÇ
Emrah EMRE
Pages
1–6
Publication Date
2015-03-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this review article, a literature survey was done about cytokeratin patterns of cholesteatoma

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Cholesteatoma is a destructive pathology characterized with progressive and chronic infiltration of keratinized squamous epithelium that can be seen the middle ear and mastoid regions of temporal bone.
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Key Findings & Data:It has serious intra and extracranial complications which can be difficult to manage.
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Conclusion & Impact:In this review article, a literature survey was done about cytokeratin patterns of cholesteatoma
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:cholesteatoma · cytokeratin

Abstract

Cholesteatoma is a destructive pathology characterized with progressive and chronic infiltration of keratinized squamous epithelium that can be seen the middle ear and mastoid regions of temporal bone. It has serious intra and extracranial complications which can be difficult to manage. Embryologic remnants of squamous epithelium, squamous metaplasia of middle ear epithelium, migration of epidermal cells from external ear canal and tympanic membrane and cell seeding because of middle ear surgery or trauma were all stated as causes of cholesteatoma. Cytokeratins are important markers of cell differentiation. The patterns of cytokeratin expression correlate well with the state of keratinocyte proliferation, migration and differentiation. These patterns are known to be affected during the formation of cholesteatoma. Increasing our knowledge about cytokeratin patterns may help us understand the unknown formation of cholesteatoma. In this review article, a literature survey was done about cytokeratin patterns of cholesteatoma

Özet

Kolesteatoma, temporal kemiğin özellikle orta kulak ve mastoid bölgele- rinde görülen, keratinize yassı epitelin ilerleyici ve kronik infiltrasyonu ile karakterize tahrip edici bir patolojidir. Tedavisi güç olabilen ciddi kafa içi ve kafa dışı komplikasyonları vardır. Kolesteatoma oluşumunda; yassı epitelin embryolojik kalıntıları, orta kulak epitelinin yassı epitel metaplazisi, dış kulak yolu ve kulak zarından epidermal hücrelerin göç etmesi ve orta kulak cerrahisi yada travma nedeniyle hücre ekimi gibi nedenler suçlanmaktadır. Sitokeratinler, hücre farklılaşmasında önemli belirleyicilerdir. Sitokeratin oluşum paternleri; keratinosit proliferasyonu, göç ve farklılaşma ile yüksek oranda ilişkilidir. Bu paternlerin, kolesteatoma oluşumu sırasında etkili ol- duğu bilinmektedir. Sitokeratin paternleri hakkında bilgilerimiz arttıkça, kolesteatoma oluşumu hakkındaki bilgilerimiz de artacaktır. Bu makalede, kolesteatomada sitokeratin paternleri hakkında bir literatür taraması yapıl- mıştır

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Cite This Article

KOÇ, A., EMRE, E. (2015). An Overview To Cytokeratin Pattern of Cholesteatoma. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, Sayı: 1, 1–6. https://ajindex.com/articles/163015

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