Here, we present a case of a 45-year-old woman with concurrent NMO and MG, aligning with findings from previous studies.
📌 3 Key Takeaways
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Objective & Hypothesis:Neuromyelitis optica (NMO, Devic syndrome) is an inflammatory, demyelinating central nervous system disorder typically associated with optic neuritis and transverse myelitis involving three or more segments in the spinal cord.
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Key Findings & Data:Myasthenia Gravis (MG) is an autoimmune disease characterized by weakness in fatiguing muscles due to impaired neuromuscular transmission.
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Conclusion & Impact:Here, we present a case of a 45-year-old woman with concurrent NMO and MG, aligning with findings from previous studies.
Neuromyelitis optica (NMO, Devic syndrome) is an inflammatory, demyelinating central nervous system disorder typically associated with optic neuritis and transverse myelitis involving three or more segments in the spinal cord. Myasthenia Gravis (MG) is an autoimmune disease characterized by weakness in fatiguing muscles due to impaired neuromuscular transmission. NMO can coexist with autoimmune diseases, and its association with myasthenia gravis is common. Studies in existing patients with both NMO and MG support that MG symptoms often appear earlier and tend to be milder. Here, we present a case of a 45-year-old woman with concurrent NMO and MG, aligning with findings from previous studies.
Akın, S. B., Atay, T., Güzel, A., Demiral, G. Z., Börü, Ü. T. (2024). Neuromyelitis Optica associated with Myastenia Gravis: A Case Report. ACH Medical journal, Volume: 3 Issue: 1. https://ajindex.com/articles/1628851
Ratelade, Julien, and AS22713791 Verkman. “Neuromyelitis optica: aquaporin-4 based pathogenesis mechanisms and new therapies.” The international journal of biochemistry & cell biology 44.9 (2012): 1519-1530.)
Graber, David J., et al. “Neuromyelitis optica pathogenesis and aquaporin 4.” Journal of neuroinflammation 5.1 (2008): 1-21
Oflazer, Piraye, Durmuş-Tekçe, Hacer, & Deymeer, Feza. (2020, July 23). KAS VE NÖROMÜSKÜLER KAVŞAK HASTALIKLARI. Istanbul Tıp Fakultesi Nöroloji Anabilim Dalı. http://www.itfnoroloji.org/kas/kasindex3.htm
Zekeridou, Anastasia, and Vanda A. Lennon. “Aquaporin-4 autoimmunity.” Neurology-Neuroimmunology Neuroinflammation 2.4 (2015)
Z, Yan Y. Immunopathogenesis in Myasthenia Gravis and Neuromyelitis Optica. Front Immunol. 2017 Dec 12;8:1785. doi: 10.3389/fimmu.2017.01785. PMID: 29312313; PMCID: PMC5732908
Berrih-Aknin, Sonia. “Myasthenia Gravis: paradox versus paradigm in autoimmunity.” Journal of autoimmunity 52 (2014): 1-28.
Leite MI, Coutinho E, Lana-Peixoto M, et al. Myasthenia gravis and neuromyelitis optica spectrum disorder: a multicenter study of 16 patients. Neurology. 2012;78(20):1601-1607. doi:10.1212/WNL.0b013e31825644ff
McKeon A, Lennon VA, Jacob A, Matiello M, Lucchinetti CF, Kale N, et al. Coexistence of myasthenia gravis and serological markers of neurological autoimmunity in neuromyelitis optica. Muscle Nerve (2009) 39:87–90. 10.1002/mus.21197
Wang Z, Yan Y. Immunopathogenesis in Myasthenia Gravis and Neuromyelitis Optica. Front Immunol. 2017 Dec 12;8:1785. doi: 10.3389/fimmu.2017.01785. PMID: 29312313; PMCID: PMC5732908.
Vaknin-Dembinsky A, Abramsky O, Petrou P, Ben-Hur T, Gotkine M, Brill L, et al. Myasthenia gravis associated neuromyelitis optica like disease: an immunological link between the central nervous system and muscle. ArchNeurol (2011) 68:1557–61. 10.1001/archneurol.2011.200
Iyer A, Elsone L, Appleton R, Jacob A. A review of thecurrentliteratureand a guide to the early diagnosis of to immune disorders associated with neuromyelitis optica. Autoimmunity (2014) 47:154–61.10.3109/08916934.2014.883501
Jarius, S., et al. “Neuromyelitis optica spectrum disorders in patients with myasthenia gravis: ten new aquaporin-4 antibody positive cases and a review of the literature.” Multiple Sclerosis Journal 18.8 (2012): 1135-1143