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Journals / ACH Medical journal / 2026 / Volume: 4 Issue: 2

From Inflammation to Frailty: Investigating the Systemic Immunity-Inflammation Index in Older Patient

Zeynep Şahiner(Ankara Bilkent Şehir Hastanesi)0000-0003-1256-4412
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Publication Date
2025-06-30
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The results of this cross-sectional study indicate a positive correlation between systemic inflammatory biomarkers (SII, SIRI) and frailty.

📌 3 Key Takeaways

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Objective & Hypothesis:Introductıon: Chronic inflammation is increasingly recognized as a crucial contributor to frailty pathogenesis, but accurate diagnosis remains a challenge.
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Key Findings & Data:Methods: This cross-sectional study enrolled 200 patients.
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Conclusion & Impact:Conclusion: The results of this cross-sectional study indicate a positive correlation between systemic inflammatory biomarkers (SII, SIRI) and frailty.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Systemic Immunity-inflammation index · Frailty · Older people

Abstract

Introductıon: Chronic inflammation is increasingly recognized as a crucial contributor to frailty pathogenesis, but accurate diagnosis remains a challenge. Aim Our study aims to investigate the relationship between frailty and the Systemic Immunity-Inflammation Index (SII, SIRI), a comprehensive indicator of inflammation. Methods: This cross-sectional study enrolled 200 patients. All participants underwent a comprehensive geriatric assessment. Frailty was assessed using the clinical frailty scale, (≥ 4; frail, 596. At this threshold, the negative predictive values were determined to be 83.8%, with a specificity of 86%, cut-off for SIRI in predicting sarcopenia as > 1.1 . Conclusion: The results of this cross-sectional study indicate a positive correlation between systemic inflammatory biomarkers (SII, SIRI) and frailty.

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Cite This Article

Şahiner, Z. (2025). From Inflammation to Frailty: Investigating the Systemic Immunity-Inflammation Index in Older Patient. ACH Medical journal, Volume: 4 Issue: 2. https://doi.org/10.5505/achmedj.2025.04127

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