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Journals / European Journal of Life Sciences / 2026 / Volume: 3 Issue: 2

Phytochemical quality analysis of commercial preparations containing Echinacea purpurea

Ayşe Esra Karadağ(ISTANBUL MEDIPOL UNIVERSITY, FACULTY OF PHARMACY)0000-0002-3412-0807
Rengin Baydar(ISTANBUL MEDIPOL UNIVERSITY)0009-0008-3754-0293
Damla Kırcı(IZMIR KATIP CELEBI UNIVERSITY)0000-0002-3479-3999
Pages
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Publication Date
2024-08-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In the sample purchased directly as a dried herb, all four of the required standards were determined to be following the ranges specified in the European Pharmacopoeia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Echinacea species have been medicinally important plants from the past to the present.
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Key Findings & Data:In the present study, it was aimed to analyze 5 different Echinacea preparations by the HPLC method.
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Conclusion & Impact:In the sample purchased directly as a dried herb, all four of the required standards were determined to be following the ranges specified in the European Pharmacopoeia.
🔬Design:Research Article
📍Scope:2 samples
⚙️Variables:Echinacea · HPLC · echinacoside

Abstract

Echinacea species have been medicinally important plants from the past to the present. Echinacea is used in many diseases, especially cold and wound treatment. The root, flower, and leaf parts of the plant, especially the flower, contain medicinally important components such as chlorogenic acid, caffeic acid, echinacoside and cichoric acid. Today, the medicinal use of the Echinacea can be achieved with its flowers and herbal teas sold in herbal markets. In addition, Echinacea preparations available in pharmacies are used especially for immune boosting and to prevent colds and flu. In the present study, it was aimed to analyze 5 different Echinacea preparations by the HPLC method. According to the HPLC results of Echinacea preparations in different forms (syrup, capsule, etc.), none of the 4 expected standards could be detected in the 2 samples stated to contain Echinacea, while 0.1% caffeic acid was detected in EP-1 and 0.4% cichoric acid, 0.6% chlorogenic acid, 0.2% caffeic acid were detected in EP-3. In the sample purchased directly as a dried herb, all four of the required standards were determined to be following the ranges specified in the European Pharmacopoeia.

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Cite This Article

Karadağ, A. E., Baydar, R., Kırcı, D. (2024). Phytochemical quality analysis of commercial preparations containing Echinacea purpurea. European Journal of Life Sciences, Volume: 3 Issue: 2. https://doi.org/10.55971/EJLS.1505892

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References (20)

  1. Huntley AL, Coon JT, Ernst E. The safety of herbal medicinal products derived from Echinacea species: A systematic review. Drug Saf. (2005); 28(5):387-400. https://doi.org/10.2165/00002018-200528050-00003
  2. Kumar K, Ramaiah S. Pharmacological importance of Echinacea purpurea. Int J Pharma Bio Sci. (2011); 2(4): 304–314.
  3. Shah SA, Sander S, White CM, Rinaldi M, Coleman CI. Evaluation of Echinacea for the prevention and treatment of the common cold: A meta-analysis. Lancet Infect Dis. (2007); 7(7):473-480. https://doi.org/10.1016/S1473-3099(07)70160-3
  4. European Directorate for the Quality of Medicines & HealthCare. (2010). European Pharmacopoeia (7th ed.). Strasbourg: Council of Europe. Volume 8.
  5. Sargin SA. Potential anti-influenza effective plants used in Turkish folk medicine: A review. J Ethnopharmacol. (2021); 265: 113319. https://doi.org/10.1016/j.jep.2020.113319.
  6. Hobbs C. Echinacea: A literature review: Botany, history, chemistry, pharmacology, toxicology, and clinical uses. Herb Gram. (1994); 30:33–48.
  7. Manayi A, Vazirian M, Saeidnia S. Echinacea purpurea: Pharmacology, phytochemistry and analysis methods. Pharmacogn Rev. (2015);9(17):63-72. https://doi.org/10.4103/0973-7847.156353
  8. Burlou-Nagy C, Bănică F, Jurca T, Vicaș LG, Marian E, Muresan ME, Bácskay I, Kiss R, Fehér P, Pallag A. Echinacea purpurea (L.) Moench: Biological and pharmacological properties. A review. Plants. (2022);11(9):1244. https://doi.org/10.3390/plants11091244
  9. Lopresti AL, Smith SJ. An investigation into the anxiety-relieving and mood-enhancing effects of Echinacea angustifolia (EP107™): A randomised, double-blind, placebo-controlled study. J Affect Disord. (2021);293:229-237. https://doi.org/10.1016/j.jad.2021.06.054
  10. Novika RGH, Wahidah NJ, Yunus A, Sumarno L, Ilyas MF. Clinical effect of Echinacea purpurea as an antiviral and its effect on reproductive hormones. J Pharm Pharmacogn Res. (2024);12(2):255–263. https://doi.org/10.56499/jppres23.1784_12.2.255
  11. Chang BY, Lee SK, Kim DE, Bae JH, Ho TT, Park SY, Lee MK, Kim SY. Effect of echinalkamide identified from Echinacea purpurea (L.) Moench on the inhibition of osteoclastogenesis and bone resorption. Sci Rep. (2020); 10: 10914. https://doi.org/10.1038/s41598-020-67890-x
  12. Vimalanathan S, Shehata M, Sadasivam K, Delbue S, Dolci M, Pariani E, D’Alessandro S, Pleschka S. Broad antiviral effects of Echinacea purpurea against SARS-CoV-2 variants of concern and potential mechanism of action. Microorganisms. (2022); 10(11):2145. https://doi.org/10.3390/microorganisms10112145
  13. Sullivan AM, Laba JG, Moore JA, Lee TDG. Echinacea-induced macrophage activation. Immunopharmacol Immunotoxicol. (2008);30(3): 553–574. https://doi.org/10.1080/08923970802135534
  14. Gancitano G, Mucci N, Stange R, Ogal M, Vimalanathan S, Sreya M, Booker A, Hadj-Cherif B, Albrich WC, Woelkart-Ardjomand K, et al. Echinacea reduces antibiotics by preventing respiratory infections: A meta-analysis (ERA-PRIMA). Antibiotics. (2024);13(4):364. https://doi.org/10.3390/antibiotics13040364
  15. Petrova A, Ognyanov M, Petkova N, Denev P. Phytochemical characterization of purple coneflower roots (Echinacea purpurea (L.) Moench.) and their extracts. Molecules. (2023); 28(9):3956. https://doi.org/10.3390/molecules28093956
  16. Kakouri E, Talebi M, Tarantilis PA. Echinacea spp.: The cold-fighter herbal remedy?. Pharmacol Res - Mod Chin Med. (2024); 10: 100397. https://doi.org/10.1016/j.prmcm.2024.100397
  17. Okur ME, Ayla Ş, Karadağ AE, Polat DÇ, Demirci S, Seçkin İ. Opuntia ficus indica fruits ameliorate cisplatin-induced nephrotoxicity in mice. Biol Pharm Bull. (2020); 43(5): 831-838. https://doi.org/10.1248/bpb.b19-01044
  18. Mølgaard P, Johnsen S, Christensen P, Cornett C. HPLC method validated for the simultaneous analysis of cichoric acid and alkamides in Echinacea purpurea plants and products. J Agric Food Chem. (2003);51(24):6922-6933. https://doi.org/10.1021/jf026158f
  19. Bauer R, Remiger P. TLC and HPLC analysis of alkamides in Echinacea Drugs. Planta Med. (1989); 55(4): 367–371. https://doi.org/10.1055/s-2006-962030
  20. Bruni R, Brighenti V, Caesar LK, Bertelli D, Cech NB, Pellati F. Analytical methods for the study of bioactive compounds from medicinally used Echinacea species. J Pharm Biomed Anal. (2018); 160: 443-477. https://doi.org/10.1016/j.jpba.2018.07.044