Journals / Journal of Medical Topics and Updates / 2025 / Cilt: 4 Sayı: 3

RSV Bronchiolitis in the Pediatric Intensive Care Unit: A Retrospective Single-Center Study

Pediatrik Yoğun Bakım Ünitesinde RSV Bronşioliti: Retrospektif Tek Merkezli Bir Çalışma

Abdulgani Gülyüz(MALATYA TURGUT ÖZAL ÜNİVERSİTESİ)0000-0001-5797-9115
Nazan Poyraz(Malatya Eğitim ve Araştırma Hastanesi)0009-0008-6586-6610
Sıla Yaldiz Ataş(Malatya Eğitim ve Araştırma Hastanesi)0009-0004-7046-2910
Emrullah Arıkanoğlu(Malatya Eğitim ve Araştırma Hastanesi)0000-0002-8356-6872
Pages
84–88
Publication Date
2025-12-31
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Seasonal clustering underscores the importance of appropriate resource planning and preventive strategies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Respiratory syncytial virus (RSV) is one of the most common causes of lower respiratory tract infections in childhood and contributes significantly to intensive care admissions, particularly among high-risk groups.
📊
Key Findings & Data:Materyals and Methods: In this retrospective study, data from 257 children admitted to the PICU with respiratory tract infection between January 1 and December 31, 2024 were reviewed.
💡
Conclusion & Impact:Seasonal clustering underscores the importance of appropriate resource planning and preventive strategies.
🔬Design:Review & Systematic Survey
📍Scope:2024 Verileri
⚙️Variables:RSV · bronchiolitis · pediatric intensive care

Abstract

Objective: Respiratory syncytial virus (RSV) is one of the most common causes of lower respiratory tract infections in childhood and contributes significantly to intensive care admissions, particularly among high-risk groups. This study aimed to evaluate the demographic, clinical, and laboratory characteristics of children admitted to the pediatric intensive care unit (PICU) with RSV bronchiolitis over a one-year period and to identify factors associated with length of stay. Materyals and Methods: In this retrospective study, data from 257 children admitted to the PICU with respiratory tract infection between January 1 and December 31, 2024 were reviewed. Nasopharyngeal swab samples of all patients were evaluated using a commercial multiplex PCR panel capable of detecting multiple respiratory pathogens. Demographic characteristics, comorbidities, laboratory parameters, and PICU length of stay were recorded. Appropriate parametric and nonparametric tests were used for statistical comparisons, and independent predictors of length of stay were evaluated using multiple linear regression analysis. Results: The mean age of RSV-positive patients was 3.3 ± 2.1 years, and 59.1% were male. The comorbidity rate was 38.1%. Rhinovirus/enterovirus was the most common viral agent (36.6%), followed by RSV (31.5%). The mean PICU stay for RSV-positive patients was 6.8 ± 2.9 days, which was longer compared to the rhinovirus/enterovirus group. Multiple regression analysis identified age, CRP level, and the presence of comorbidity as independent predictors of longer length of stay (p < 0.05). RSV cases showed a marked increase during the winter months. Conclusions: RSV bronchiolitis continues to represent a significant clinical burden in pediatric intensive care practice. Early identification of factors associated with prolonged hospitalization is crucial for optimizing the management and monitoring of high-risk children. Seasonal clustering underscores the importance of appropriate resource planning and preventive strategies.

Özet

Amaç: Solunum sinsityal virüsü (RSV), çocukluk çağında alt solunum yolu enfeksiyonlarının en sık nedenlerinden biridir ve özellikle yüksek riskli gruplarda yoğun bakım yatışlarına önemli ölçüde katkıda bulunur. Bu çalışmada, bir yıllık dönemde RSV bronşioliti nedeniyle çocuk yoğun bakım ünitesine (ÇYBÜ) yatırılan hastaların demografik, klinik ve laboratuvar özelliklerinin değerlendirilmesi ve yatış süresi ile ilişkili faktörlerin belirlenmesi amaçlandı. Materyal ve Metot: Bu retrospektif çalışmada, 1 Ocak–31 Aralık 2024 tarihleri arasında solunum yolu enfeksiyonu nedeniyle ÇYBÜ’ye yatırılan 257 çocuğun verileri incelendi. Tüm hastaların nazofaringeal sürüntü örnekleri, çoklu solunum yolu patojenlerini saptayabilen ticari bir multipleks PCR paneli ile değerlendirildi. Demografik özellikler, komorbiditeler, laboratuvar parametreleri ve ÇYBÜ yatış süresi kaydedildi. Gruplar arası karşılaştırmalar için uygun parametrik ve non-parametrik testler kullanıldı; yatış süresinin bağımsız belirleyicileri çoklu doğrusal regresyon analizi ile değerlendirildi. Bulgular: RSV pozitif hastaların ortalama yaşı 3,3 ± 2,1 yıl olup %59,1’i erkekti. Komorbidite oranı %38,1 olarak bulundu. En sık saptanan viral etken rinovirüs/enterovirüs (%36,6) iken bunu RSV (%31,5) izledi. RSV pozitif hastalarda ortalama ÇYBÜ yatış süresi 6,8 ± 2,9 gün olup, bu süre rinovirüs/enterovirüs grubuna kıyasla daha uzundu. Çoklu regresyon analizinde yaş, CRP düzeyi ve komorbidite varlığı daha uzun yatış süresinin bağımsız belirleyicileri olarak saptandı (p < 0,05). RSV olgularında kış aylarında belirgin bir artış gözlendi. Sonuç: RSV bronşioliti, çocuk yoğun bakım pratiğinde önemli bir klinik yük oluşturmaya devam etmektedir. Uzamış hastane yatışı ile ilişkili faktörlerin erken dönemde belirlenmesi, yüksek riskli çocukların izlem ve yönetiminin optimize edilmesi açısından kritik öneme sahiptir. Mevsimsel kümelenme, kaynak planlaması ve koruyucu stratejilerin önemini vurgulamaktadır.

🔖

Cite This Article

Gülyüz, A., Poyraz, N., Ataş, S. Y., Arıkanoğlu, E. (2025). RSV Bronchiolitis in the Pediatric Intensive Care Unit: A Retrospective Single-Center Study. Journal of Medical Topics and Updates, Cilt: 4 Sayı: 3, 84–88. https://doi.org/10.58651/jomtu.1827660

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (20)

  1. Li Y, Wang X, Blau DM, et al. Global burden of acute lower respiratory infections due to RSV in children younger than 5 years in 2019. Lancet. 2022;399(10340):2047–2064.
  2. doi: 10.1016/S0140-6736(22)00563-4 2. Hall CB, Weinberg GA, Iwane MK, et al. The burden of RSV infection in young children. N Engl J Med. 2009;360(6):588–598. doi: 10.1056/NEJMoa0804877
  3. Ghazaly M, Nadel S. Characteristics of children admitted to intensive care with acute bronchiolitis. Eur J Pediatr. 2018;177(6):913–920. doi: 10.1007/s00431-018-3142-x
  4. Mahony JB. Detection of respiratory viruses by molecular methods. Clin Microbiol Rev. 2008;21(4):716–747. doi: 10.1128/CMR.00037-08
  5. Clark TW, Lindsley K, Wigmosta TB, et al. Rapid multiplex PCR for respi-ratory viruses: a systematic review and meta-analysis. J Infect. 2023;86(5):462– 475. doi: 10.1016/j.jinf.2023.02.019
  6. Esen AB, Erol M, Kafadar D, et al. Progression of disease and viral agents in infants hospitalized for LRTIs. J Pediatr Res. 2019;6(4):314–321. doi: 10.4274/jpr.galenos.2019.89146
  7. Yüksel H, Yılmaz Ö, Akçalı S, et al. Viral etiologies of community-acquired lower RTIs in young children. Turk Arch Pediatr. 2020;14(1):27–32. doi: 10.14744/TurkPediatriArs.2019.19047
  8. Hammitt LL, Dagan R, Yuan Y, et al. Nirsevimab for prevention of RSV in infants. N Engl J Med. 2022;386(9):837–846. doi: 10.1056/NEJMoa2110275
  9. Troeger C, Blacker B, Khalil IA, et al. Estimates of morbidity, mortality, and etiologies of lower respiratory infections in 195 countries, 1990–2016. Lancet Infect Dis. 2018;18(11):1191–1210. doi: 10.1016/S1473-3099(18)30310-4
  10. World Medical Association. World Medical Association Declaration of Helsinki. JAMA. 2013;310(20):2191–2194. doi: 10.1001/jama.2013.281053
  11. Brendish NJ, Malachira AK, Armstrong L, et al. Routine molecular point-of-care testing for respiratory viruses. Lancet Respir Med. 2017;5(5):401– 411. doi: 10.1016/S2213-2600(17)30120-0
  12. Meissner HC. Viral bronchiolitis in children. N Engl J Med. 2016;374(1):62– 72. doi: 10.1056/NEJMra1413456
  13. Heikkinen T, Järvinen A. The common cold. Lancet. 2003;361(9351):51–59. doi: 10.1016/S0140-6736(03)12162-9
  14. O’Brien KL, Baggett HC, Brooks WA, et al. Causes of severe pneumonia requiring hospital admission in children without HIV infection (PERCH study). Lancet. 2019;394(10200):757–779. doi: 10.1016/S0140-6736(19)30721-4
  15. Jacobs SE, Lamson DM, Kirsten S, et al. Human rhinoviruses. Clin Microbiol Rev. 2013;26(1):135–162. doi: 10.1128/CMR.00077-12
  16. Calvo C, García-García ML, Blanco C, et al. Multiple viral infections in infants with acute RTIs. J Clin Virol. 2008;42(3):268–272. doi: 10.1016/j.jcv.2008.02.011
  17. Esposito S, Mencacci A, Cenci E, et al. Multiplex platforms for identification of respiratory pathogens. Front Cell Infect Microbiol. 2019;9:196. doi: 10.3389/fcimb.2019.00196
  18. Killien EY, Keller MR, Watson RS, et al. Epidemiology of intensive care admissions among US children, 2001–2019. JAMA Pediatr. 2023;177(5):506– 515. doi: 10.1001/jamapediatrics.2022.6449
  19. Perez A, Lively JY, Curns A, et al. Respiratory virus surveillance in children — 2016–2021. MMWR Morb Mortal Wkly Rep. 2022;71(40):1253–1259. doi: 10.15585/mmwr.mm7140a2
  20. Griffiths C, Drews SJ, Marchant DJ. Respiratory syncytial virus: infection, detection, prevention, and treatment. Clin Microbiol Rev. 2017;30(1):277–319. doi: 10.1128/CMR.00090-16