SavedAdd your journal

Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2019 / Cilt: 25 - Sayı: 3

Can Testicular Size Be a Predictive Factor for Successful Sperm Retrieval in Patients with Non-Obstructive Azoospermia?

Ömer Hamid YUMUŞAK
MEHMET ÇINAR
SERKAN KAHYAOĞLU
Gul Nihal BUYUK
Ayşegül ÖKSÜZOĞLU
Yasemin TAŞCI
Pages
153–157
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Testicular volume, serum follicle stimulating hormone and testosterone levels can be predictive factors for sperm retrieval in men with non-obstructive azoospermia.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:OBJECTIVE: Non-obstructive azoospermia, defined as absence of spermatozoa in the ejaculate caused by impaired spermatogenesis, is the most severe cause of male infertility.
📊
Key Findings & Data:STUDY DESIGN: The medical records of 80 non-obstructive men with azoospermia who underwent micro-TESE were retrospectively evaluated.
💡
Conclusion & Impact:Testicular volume, serum follicle stimulating hormone and testosterone levels can be predictive factors for sperm retrieval in men with non-obstructive azoospermia.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

OBJECTIVE: Non-obstructive azoospermia, defined as absence of spermatozoa in the ejaculate caused by impaired spermatogenesis, is the most severe cause of male infertility. It is typically presented as high serum follicle stimulating hormone levels and atrophic testis. The combination of intracytoplasmic sperm injection and Microdissection testicular sperm extraction allows these infertile men the opportunity to have their own children from their own testis. Our aim was to evaluate the outcomes of micro-Testicular sperm extraction in men with atrophic testis. STUDY DESIGN: The medical records of 80 non-obstructive men with azoospermia who underwent micro-TESE were retrospectively evaluated. We assessed clinical parameters; age, duration of infertility, smoking, chromosomal karyotype, Y chromosome microdeletion, follicle stimulating hormone, luteinizing hormone, total testosterone and testicular volume in relation with Microdissection testicular sperm extraction results. RESULTS: Testicular sperm retrieval rate was 53% in 80 patients. Testicular volume, serum follicle stimulating hormone and total testosterone concentrations showed correlation with the results of sperm retrieval. These three parameters were found to be significant risk factors with testicular sperm extraction negative patients (p<0.001). The odds ratios (95% CI) were 6.39 (1.25-26.58), 1.24 (1.11-1.36), 1.13 (0.99-1.21) respectively. Testicular volume was found to be a discriminative parameter in patients with negative sperm retrieval. The cut-off point was established as 6.75 mL for testicular volume with 88.1% sensitivity, 62.1% specificity. CONCLUSION: Microdissection testicular sperm extraction is the most effective procedure for patients with non-obstructive azoospermia. Testicular volume, serum follicle stimulating hormone and testosterone levels can be predictive factors for sperm retrieval in men with non-obstructive azoospermia.

🔖

Cite This Article

YUMUŞAK, Ö. H., ÇINAR, M., KAHYAOĞLU, S., BUYUK, G. N., ÖKSÜZOĞLU, A., TAŞCI, Y. (2019). Can Testicular Size Be a Predictive Factor for Successful Sperm Retrieval in Patients with Non-Obstructive Azoospermia?. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 25 - Sayı: 3, 153–157. https://ajindex.com/articles/161821

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Esteves SC. Clinical management of infertile men with non-obstructive azoospermia. Asian J Androl. 2015;17(3): 459-70
  2. Wostnitzer M, Goldstein M, Hardy MP. Review of azoospermia. Spermatogenesis. 2014; 4:e28218
  3. Esteves SC, Miyaoka R, Agarwal A. Sperm retrieval techniques for assisted reproduction. Int Braz J Urol. 2011; 37(5):570-83
  4. Schlegel PN, Li PS. Microdissection TESE: sperm retrieval in non-obstructive azoospermia. Hum Reprod Update. 1998; 4(4):439
  5. Schlegel PN. Nonobstructive azoospermia: a revolutionary surgical approach and results. Semin Reprod Med. 2009;27(2):165-70
  6. Bonarriba CR, Burgués JP, Vidaña V, Ruiz X, Pizá P. Predictive factors of successful sperm retrieval in azoospermia. Actas Urol Esp. 2012; 37(5):266-72
  7. WHO. World Health Organization: WHO Laboratory manual for the examination and processing of human semen - 5th ed. Geneva: WHO Press 2010
  8. Sakamoto H, Ogawa Y, Yoshida H. Relationship between testicular volume and testicular function: comparison of the prader orchidometric and ultrasonographic measurements in patients with infertility. Asian J Androl. 2008;10(2):319-24
  9. Devroey P, Liu J, Nagy Z, Goossens A, Tournaye H, Camus M, et al. Pregnancies after testicular sperm extraction and intracytoplasmic sperm injection in non-obstructive azoospermia. Hum Reprod. 1995;10(6):1457-60
  10. Schlegel PN. Testicular sperm extraction: microdissection improves sperm yield with minimal tissue excision. Hum Reprod. 1999;14(1):131-5
  11. Deruyver Y, Vanderschueren D, Van der Aa F. Outcome of microdissection TESE compared with conventional TESE in nonobstructive azoospermia: a systematic review. Andrology. 2014;2(1):20-4
  12. Bernie AM, Mata DA, Ramasamy R, Schlegel PN. Comparison of microdissection testicular sperm extraction, conventional testicular sperm extraction, and testicular sperm aspiration for nonobstructive azoospermia: a systematic review and meta-analysis. Fertil Steril. 2015; 104(5):1099-103.e1-3 13. Marconi M, Keudel A, Diemer T, Bergmann M, Steger K, Schuppe HC, et al. Combined trifocal and microsurgical testicular sperm extraction is the best technique for testicular sperm retrieval in “low-chance” nonobstructive azoospermia. Eur Urol. 2012; 62(4):713-9
  13. Bromage SJ, Falconer DA, Lieberman BA, Sangar V, Payne SR. Sperm retrieval rates in subgroups of primary azoospermic males. Eur Urol. 2007;51(2):534-9
  14. Ziaee SA, Ezzatnegad M, Nowroozi M, Jamshidian H, Abdi H, Hosseini Moghaddam SM. Prediction o