Journals / Çocuk Enfeksiyon Dergisi / 2017 / Cilt: 11 - Sayı: 2

Evaluation of Roseala Infantum Cases in Terms of Demographic Properties and Laboratory Values

Roseola İnfantum Olgularının Demografik ve Laboratuvar Değerleri Açısından Değerlendirilmesi

Pages
63–70
DOI
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Conclusion: Under three years of age children (especially young infants) with fever without source accompanying neutropenia, relative lymphocytosis, mild AST elevation and negative CRP roseola infantum should be considered as an etiological factor.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: To share our experince from demographic and labaratory results of 46 patients who applied to our policlinic with complaints of fever and rash and diagnosed as roseola infantum between 2012-2016.
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Key Findings & Data:Material and Methods: Labaratory and demographic findings of 41 patients who diagnosed as roseola infantum clinically had been evaluated.
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Conclusion & Impact:Conclusion: Under three years of age children (especially young infants) with fever without source accompanying neutropenia, relative lymphocytosis, mild AST elevation and negative CRP roseola infantum should be considered as an etiological factor.
🔬Design:Research Article
📍Scope:2012-2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Objective: To share our experince from demographic and labaratory results of 46 patients who applied to our policlinic with complaints of fever and rash and diagnosed as roseola infantum between 2012-2016. Material and Methods: Labaratory and demographic findings of 41 patients who diagnosed as roseola infantum clinically had been evaluated. Roseala infantum cases were diagnosed as 10 mo old infant with high temperature over three days and nontoxic maculopapuller rash on the trunk and after making differential diagnosis of other diseases that courses with skin rash and high body temperature. Neutrophil counts between 0-500, 500-1000 and 1000-1500 were accepted as high, medium and low, respectively. Results: 25 of the patients were female (54.3%), 21 of them were male (45.7%), mean age was 11.5 ± 7.02 (3-36 months) and peak age of onset was 9-11 months. 76% of patients were (35/46) under one years of age. Disease was seen all year round but it was seen least at September and October and was seen mostly at December. Mean labaratory leves were found as: Hb 11.8 ± 0.97 g/L, HCT 35.0% ± 3.2, MCV 73.7 ± 5.10 fL, platelet count 299 ± 128.8 x 109/L, leukocyte count 7.6 ± 2.8 x 109/L, neutrophil count 1.7 ± 1.30 x 109/L, lymphocyte count 5.0 ± 2.2 x 109/L, mean C-reactive protein 4.0 ± 4.5 mg/L, AST 50 ± 14.8 U/L, ALT 24 ± 10.7 U/L, LDH 385 ± 96.6 U/L. 57.5% of the patients had neutropenia (10% severe, 35% moderate and 12.5% mild) and neutropenia resolved in one months. Mean lymphocyte/neutrophil rate was calculated as 2.94 (relative lymphocytosis). None of the patients experienced infections secondary to neutropenia and febrile convulsion. Conclusion: Under three years of age children (especially young infants) with fever without source accompanying neutropenia, relative lymphocytosis, mild AST elevation and negative CRP roseola infantum should be considered as an etiological factor.

Özet

Giriş: Bu çalışmanın amacı 2012-2016 yılları arasında yüksek ateş, dö- küntü nedeniyle polikliniğimize başvuran klinik olarak roseola infantum tanısı konan 46 hastanın demografik ve laboratuvar bulgularından edi- nilen deneyimi paylaşmaktır. Gereç ve Yöntemler: Klinik olarak roseola infantum tanısı konan 41 hastanın laboratuvar ve demografik bulguları değerlendirildi. Hastalı- ğın tanısı ateş ve döküntüye neden olabilecek diğer hastalıkların ayı- rıcı tanısı yapıldıktan sonra, “üç günden beri devam eden yüksek ateş, toksik olmayan 10 aylık bir bebeğin gövdesinde makülopapüler dö- küntü” olması roseola infantum olarak değerlendirildi. Nötrofil sayısı 0-500 ise ağır, 500-1000 ise orta, 1000-1500 ise hafif nötropeni olarak değerlendirildi. Bulgular: Hastaların 25 (%54.3)’i kız, 21 (%45.7)’i erkek, yaş ortalaması 11.5 ± 7.02 (3-36 ay) ve başlangıç pik yaşı 9-11 ay idi. Hastaların %76’sı (35/46) bir yaşın altında idi. Hastalık tüm yıl boyunca görülmekle bir- likte en az Eylül ve Ekim ayında, en çok Aralık ayında gözlendi. Hasta- ların sırasıyla ortalama Hb 11.8 ± 0.97 g/L, HCT %35.0 ± 3.2, MCV 73.7 ± 5.10 fL, trombosit sayısı 299 ± 128.8 x 109/L, lökosit sayısı 7.5 ± 2.8 x 109/L, nötrofil sayısı 1.7 ± 1.30 x 109/L, lenfosit sayısı 5.0 ± 2.2 x 109/L, ortalama C-reaktif protein (CRP) değeri 4.0 ± 4.5 mg/L, AST 50 ± 14.8 U/L, ALT 24 ± 10.7 U/L, LDH 385 ± 96.6 U/L olarak bulundu. Hastaların %57.5’inde nötropeni (%10 ağır, %35 orta ve %12.5 hafif) vardı. Ortalama lenfosit/nötrofil oranı 2.94 (rölatif lenfositoz) olarak hesaplandı. Hastaların hiçbirinde nötropeniye sekonder enfeksiyon ve febril kon- vülzyon gözlenmedi. Sonuç: Nötropeni, relatif lenfositoz, hafif AST yüksekliği ve CRP negatif- liği saptanan üç yaşın altındaki çocuklarda (özellikle bir yaşın altındaki bebeklerde) kaynağı saptanamayan ateş nedeni olarak roseola infantum da akla gelmelidir.

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Cite This Article

BIÇAKCI, Z., ARVAS, M. H., BİÇER, C., AKAY, A., ÜSTEBAY, S., ÜSTEBAY, D. Ü. (2017). Evaluation of Roseala Infantum Cases in Terms of Demographic Properties and Laboratory Values. Çocuk Enfeksiyon Dergisi, Cilt: 11 - Sayı: 2, 63–70. https://ajindex.com/articles/161573

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References (2)

  1. De Bolle L, Naesens L, De Clercq E. Update on human herpesvirus 6 biology, clinical features, and therapy. Clin Microbiol Rev 2005;18:217- 45. [CrossRef] Ward KN. The natural history and laboratory diagnosis of human herpesviruses-6 and -7 infections in the immunocompetent. J Clin Virol 2005;32:183-93. [CrossRef] Bates M, Monze M, Bima H, et al. Predominant human herpesvirus 6 variant A infant infections in an HIV-1 endemic region of Sub-Saharan Africa. J Med Virol 2009;81:779-89. [CrossRef] Pruksananonda P, Hall CB, Insel RA, et al. Primary human herpesvirus 6 infection in young children. N Engl J Med 1992;326:1445-50. [CrossRef] Caserta MT. Roseola (Human Herpesviruses 6 and 7). In: Kliegman RM, Stanton BF, ST Geme JW, Schor NF, Behrman RE (eds). Nelson Textbook of Pediatrics, 19th ed. Philadelphia (PA): Elsevier Saunders, 2011;1594- 7. Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children. A prospective study of complications and reactivation. N Engl J Med 1994;331:432-8. [CrossRef] Caserta MT, Mock DJ, Dewhurst S. Human herpesvirus 6. Clin Infect Dis 2001;33:829-33. [CrossRef] Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest 2003;111:1805-12. [CrossRef] Markanday A. Acute phase reactants in infections: evidence-based review and a guide for clinicians. Open Forum Infect Dis 2015;2:ofv098. [CrossRef] Miura H, Kawamura Y, Ozeki E, Ihira M, Ohashi M, Yoshikawa T. Pathogenesis of severe neutropenia in patients with primary human herpesvirus 6B infection. Pediatr Infect Dis J 2015;34:1003-7. [CrossRef] Husain EH, Mullah-Ali A, Al-Sharidah S, Azab AF, Adekile A. Infectious etiologies of transient neutropenia in previously healthy children. Pediatr Infect Dis J 2012;31:575-7. [CrossRef] Abbas AK, Lichtman AH, Pillai S. Cytokines. In: Abbas AK, Lichtman AH, Pillai S (eds). Cellular and molecular immunology (6th ed). Philadelphia, PA: Saunders, 2007:267-301.
  2. Knox KK, Carrigan DR. In vitro suppression of bone marrow progenitor cell differentiation by human herpesvirus 6 infection. J Infect Dis 1992;165:925-9. [CrossRef] Isomura H, Yamada M, Yoshida M, et al. Suppressive effects of human herpesvirus 6 on in vitro colony formation of hematopoietic progenitor cells. J Med Virol 1997;52:406-12. [CrossRef] Hall CB, Caserta MT. Human Herpesviruses 6 and 7 (Roseola, Exanthem Subitum). In: Long SS, Pickering LK, Prober CG (eds). Principles and Practice of Pediatric Infectious Diseases. 4th ed. China: Elsevier Saunde