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Journals / HRÜ Uluslararası Diş Hekimliği ve Oral Araştırmalar Dergisi / 2025 / Volume: 5 Issue: 3

Therapeutic and Regenerative Applications of Propolis in Oral and Maxillofacial Surgery: A Current Review

Halil İbrahim Durmuş(HARRAN ÜNİVERSİTESİ)0000-0003-4762-4788
Kağan Fatih Kuşan(ADIYAMAN ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ)0009-0007-0080-8703
Tevfik Kızılseki(ADIYAMAN ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ)0009-0009-8173-0550
Karahan Uçar(ADIYAMAN ÜNİVERSİTESİ, DİŞ HEKİMLİĞİ FAKÜLTESİ)0009-0002-0656-2437
Pages
—
Publication Date
2025-12-31
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Keywords: Propolis; Oral and Maxillofacial Surgery; Bone Regeneration; MRONJ; Wound Healing; Dental Implant.

📌 3 Key Takeaways

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Objective & Hypothesis:Abstract Objective: This narrative review evaluates the therapeutic and regenerative uses of propolis in oral and maxillofacial surgery (OMFS), together with its chemical composition, biological effects, and clinical potential.
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Key Findings & Data:Materials and Methods: Experimental, clinical, and review studies published between 2000 and 2025 were searched in PubMed, Scopus, and Web of Science using the terms “propolis,” “oral surgery,” “bone regeneration,” “MRONJ,” “implant,” and “wound healing.” Results: Propolis—rich in flavonoids, phenolic acids, and terpenoids—supports oral wound healing and bone regeneration via anti-inflammatory, antioxidant, and antimicrobial mechanisms.
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Conclusion & Impact:Keywords: Propolis; Oral and Maxillofacial Surgery; Bone Regeneration; MRONJ; Wound Healing; Dental Implant.
🔬Design:Review & Systematic Survey
📍Scope:2000 Verileri
⚙️Variables:Propolis · Oral and Maxillofacial Surgery · Bone Regeneration

Abstract

Abstract Objective: This narrative review evaluates the therapeutic and regenerative uses of propolis in oral and maxillofacial surgery (OMFS), together with its chemical composition, biological effects, and clinical potential. Materials and Methods: Experimental, clinical, and review studies published between 2000 and 2025 were searched in PubMed, Scopus, and Web of Science using the terms “propolis,” “oral surgery,” “bone regeneration,” “MRONJ,” “implant,” and “wound healing.” Results: Propolis—rich in flavonoids, phenolic acids, and terpenoids—supports oral wound healing and bone regeneration via anti-inflammatory, antioxidant, and antimicrobial mechanisms. Preclinical and limited clinical data report accelerated epithelialization, enhanced osteogenic activity in bone defects, reduced peri-implant inflammation, and a potential protective effect against MRONJ. However, geographic/botanical variability in composition highlights the need for clinical standardization. Conclusion: Propolis is generally well tolerated and exhibits multimodal biological activity, with supportive potential in OMFS for wound healing, bone regeneration, and infection control. Confirmation of clinical efficacy and formulation standardization requires multicenter advanced-phase trials. Keywords: Propolis; Oral and Maxillofacial Surgery; Bone Regeneration; MRONJ; Wound Healing; Dental Implant.

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Cite This Article

Durmuş, H. İ., Kuşan, K. F., Kızılseki, T., Uçar, K. (2025). Therapeutic and Regenerative Applications of Propolis in Oral and Maxillofacial Surgery: A Current Review. HRÜ Uluslararası Diş Hekimliği ve Oral Araştırmalar Dergisi, Volume: 5 Issue: 3. https://doi.org/10.61139/ijdor.1803201

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