Journals / Eskisehir Medical Journal / 2026 / Volume: 7 Issue: 2

A Rare Coexistence of Seropositive Rheumatoid Arthritis and HLA-B27 Positive Crohn-Related Spondyloarthritis

Seropozitif Romatoid artrit ve HLA-B27 pozitif Crohn ilişkili Spondiloartritin nadir bir birlikteliği

Yasemin Tombak(ANKARA ETLIK CITY HOSPITAL)0000-0003-0065-5376
Emel Eksioglu(ANKARA ETLIK CITY HOSPITAL)0000-0002-7695-0614
Ajda Bal(ANKARA ETLIK CITY HOSPITAL)0000-0002-3910-2851
Meltem Türk Alkan(ANKARA ETLIK CITY HOSPITAL)0000-0003-3975-331X
Pages
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Publication Date
2026-05-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This case emphasizes that skeletal involvement in CD can develop before bowel complaints, and patients with axial SpA experiencing bowel symptoms should be closely monitored for potential signs of inflammatory bowel disease.

📌 3 Key Takeaways

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Objective & Hypothesis:Rheumatoid arthritis (RA) is a symmetrical joint inflammation, whereas Crohn's disease (CD) is characterized by granulomatous inflammation.
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Key Findings & Data:Combining seropositive RA with axial spondyloarthritis (SpA) and human leukocyte antigen (HLA)-B27 positive CD is a rare occurrence.
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Conclusion & Impact:This case emphasizes that skeletal involvement in CD can develop before bowel complaints, and patients with axial SpA experiencing bowel symptoms should be closely monitored for potential signs of inflammatory bowel disease.
🔬Design:Case Report
📍Scope:Comprehensive Sample
⚙️Variables:Anti-TNF · crohn · rheumatoid arthritis

Abstract

Rheumatoid arthritis (RA) is a symmetrical joint inflammation, whereas Crohn's disease (CD) is characterized by granulomatous inflammation. Combining seropositive RA with axial spondyloarthritis (SpA) and human leukocyte antigen (HLA)-B27 positive CD is a rare occurrence. We report the case of a 64-year-old male patient with RA and axial SpA experienced diarrhea recently. He had previously experienced joint pain, swelling, and inflammatory type neck, back, and bilateral hip pain. The patient had discontinued treatment and failed to attend follow-up appointments. He had swollen joints, abdominal distension, tenderness, and inflammatory bowel disease. Colonoscopy revealed numerous linear ulcers in the terminal ileum and aphthous ulcers in the ileocecal valve and sigmoid colon. Histopathological examination indicated active ileitis signs consistent with CD. The patient responded well to subcutaneous anti-tumor necrosis factor (TNF) alpha therapy. This case emphasizes that skeletal involvement in CD can develop before bowel complaints, and patients with axial SpA experiencing bowel symptoms should be closely monitored for potential signs of inflammatory bowel disease.

Özet

Romatoid artrit (RA) simetrik bir eklem iltihabıdır, Crohn hastalığı (CH) ise granülomatöz iltihap ile karakterizedir. Seropozitif RA'nın aksiyel spondiloartropati (SpA) ve insan lökosit antijeni HLA-B27 pozitif CH ile birleşmesi nadir görülen bir durumdur. Bu çalışmada RA ve aksiyel SpA'sı olan ve yakın zamanda ishal olan 64 yaşında bir erkek hastayı bildiriyoruz. Hasta, daha önce eklem ağrısı, şişlik ve inflamatuar tipte boyun, sırt ve bilateral kalça ağrısı yaşamıştı. Tedavisini bırakmış ve takip randevularına katılmamıştı. Eklem şişliği, karında şişlik, hassasiyet ve inflamatuar bağırsak hastalığı vardı. Kolonoskopide terminal ileumda çok sayıda lineer ülser ve ileoçekal kapak ile sigmoid kolonda aftöz ülserler ortaya çıktı. Histopatolojik inceleme CH ile uyumlu aktif ileit bulguları gösterdi. Hastaya subkutan bir anti-TNF ajanı uygulandı. Bu vaka, CH'de iskelet tutulumunun bağırsak şikayetlerinden önce gelişebileceğini ve bağırsak semptomları yaşayan aksiyel SpA'lı hastaların olası inflamatuar bağırsak hastalığı belirtileri açısından yakından izlenmesi gerektiğini vurgulamaktadır.

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Cite This Article

Tombak, Y., Eksioglu, E., Bal, A., Alkan, M. T. (2026). A Rare Coexistence of Seropositive Rheumatoid Arthritis and HLA-B27 Positive Crohn-Related Spondyloarthritis. Eskisehir Medical Journal, Volume: 7 Issue: 2. https://ajindex.com/articles/1614210

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