SavedAdd your journal

Journals / Experimental Biomedical Research / 2020 / Cilt: 3 - Sayı: 3

Serum levels of anti-carbonic anhydrase antibodies and erythrocyte oxidative stress markers in endometriosis

Ülkü Mete URAL
Ahmet ALVER
Hasan EFE
Ayşe ŞENTÜRK
İmran İNCE
Beril GÜRLEK
Pages
126–132
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Our results indicate that erythrocyte oxidative stress and anti-carbonic anhydrase antibodies may be involved in the pathophysiology of endometriosis.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To evaluate the serum levels of anti-carbonic anhydrase I-II antibodies and erythrocyte oxidative stress markers in endometriosis.
📊
Key Findings & Data:Serum anti-carbonic anhydrase I and II antibodies and erythrocyte oxidative stress markers (superoxide dismutase, malondialdehyde, glutathione peroxidase and catalase) were compared with control group (n = 30) in the endometriosis group (n = 33).
💡
Conclusion & Impact:Conclusions: Our results indicate that erythrocyte oxidative stress and anti-carbonic anhydrase antibodies may be involved in the pathophysiology of endometriosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Aim: To evaluate the serum levels of anti-carbonic anhydrase I-II antibodies and erythrocyte oxidative stress markers in endometriosis. Method: This case-control laboratory investigation was performed in the obstetrics and gynecology department of a tertiary center. Serum anti-carbonic anhydrase I and II antibodies and erythrocyte oxidative stress markers (superoxide dismutase, malondialdehyde, glutathione peroxidase and catalase) were compared with control group (n = 30) in the endometriosis group (n = 33). Correlation between carbonic anhydrase autoantibodies and oxidative stress markers were tested. Results: Serum levels of anti-carbonic anhydrase II antibodies were found to be significantly increased in the endometriosis group compared to controls. The erythrocyte antioxidant enzyme activities (superoxide dismutase, glutathione peroxidase and catalase) and malondialdehyde levels in erythrocytes were increased in endometriosis group; but only glutathione peroxidase activity and malondialdehyde levels were significantly higher in endometriosis group. No correlation was detected between anti-carbonic anhydrase antibodies and oxidative stress markers. Conclusions: Our results indicate that erythrocyte oxidative stress and anti-carbonic anhydrase antibodies may be involved in the pathophysiology of endometriosis.

🔖

Cite This Article

URAL, Ü. M., ALVER, A., EFE, H., ŞENTÜRK, A., İNCE, İ., GÜRLEK, B. (2020). Serum levels of anti-carbonic anhydrase antibodies and erythrocyte oxidative stress markers in endometriosis. Experimental Biomedical Research, Cilt: 3 - Sayı: 3, 126–132. https://ajindex.com/articles/160982

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility. Obstet Gynecol Clin North Am. 2012
  2. 39(4):535-49. [2]Gupta S, Agarwal A, Krajcir N, et al. Role of oxidative stress in endometriosis. Reprod Biomed Online. 2006
  3. 13(1):126-34. [3]Yeaman GR, Collins JE, Lang GA. Autoantibody responses to carbohydrate epitopes in endometriosis. Ann N Y Acad Sci. 2002
  4. Andrisani A, Donà G, Brunati AM, et al. Increased oxidation-related glutathionylation and carbonic anhydrase activity in endometriosis. Reprod Biomed Online. 2014
  5. 28(6):773-79. [5]Lang GA, Yeaman GR. Autoantibodies in endometriosis sera recognize a ThomsenFriedenreich-like carbohydrate antigen. J Autoimmun. 2001
  6. 16(2):151-61. [6]Supuran CT, Scozzafava A. Carbonic anhydrases as targets for medicinal chemistry. Bioorg Med Chem. 2007
  7. 15(13):4336-50. [7]Pertovaara M, Parkkila S, Korpela M. Anticarbonic anhydrase autoantibodies and serum beta-2 microglobulin correlate with the ClinESSDAI score in patients with Sjögren's syndrome. Clin Exp Rheumatol. 2017
  8. 35(2):351. [8]Alver A, Senturk A, Cakirbay H, et al. Carbonic anhydrase II autoantibody and oxidative stress in rheumatoid arthritis. Clin Biochem. 2011
  9. 44(17-18):1385-89. [9]Alver A, Mentese A, Karahan SC. Increased Serum Anti-Carbonic Anhydrase II Antibodies in patients with Graves ’ disease. Exp Clin Endocrinol. 2007
  10. 115(5):287-91. [10]Adamus G, Yang S, Weleber RG. Unique epitopes for carbonic anhydrase II autoantibodies related to autoimmune retinopathy and cancer-associated retinopathy. Exp Eye Res. 2016
  11. Iuchi Y, Okada F, Onuma K, et al. Elevated oxidative stress in erythrocytes due to SOD1 deficiency causes anemia and triggers autoantibody production. Biochem J. 2007
  12. 402(2):219-27. [12]Alver A, İmamoğlu M, Menteşe A, et al. Malondialdehyde and CA II autoantibody levels are elevated in children with undescended testes. World J Urol. 2014
  13. 32(1):209-13. [13]Carl H, Soumya R, Srinivas P, et al. Oxidative stress in erythrocytes of banked ABO blood. Hematology. 2016
  14. 21(10):630- 34. [14]Ansari FA, Ali SN, Mahmood R. Sodium nitrite-induced oxidative stress causes membrane damage, protein oxidation, lipid peroxidation and alters major metabolic pathways in human erythrocytes. Toxicol In Vitro. 2015
  15. 29(7):1878-86. [15]Caccavo D, Afeltra A, Rigon A, et al. Antibodies to carbonic anhydrase in patients with connective tissue diseases: relationship with lung