SavedAdd your journal

Journals / Experimental Biomedical Research / 2019 / Cilt: 2 - Sayı: 4

Frequency of uveitis and its associations with HLA B27 in ankylosing spondylitis patients

Ayse Kevser DEMİR
Hulya DEVECİ
Selim DEMİR
Pages
132–135
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In our study, no significant difference was found between the presence of uveitis and the presence of HLA B27 in patients with AS and this finding needs to be supported by randomized studies.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To investigate the prevalence of uveitis in ankylosing spondylitis (AS) patients and its relationship with HLA B27.
📊
Key Findings & Data:Methods: The data of 95 patients with AS who admitted to Tokat Gaziosmanpaşa University Internal Medicine and Rehabilitation Outpatient Clinics between 2010 and 2019 were analyzed retrospectively.
💡
Conclusion & Impact:In our study, no significant difference was found between the presence of uveitis and the presence of HLA B27 in patients with AS and this finding needs to be supported by randomized studies.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Özet

Aim: To investigate the prevalence of uveitis in ankylosing spondylitis (AS) patients and its relationship with HLA B27. Methods: The data of 95 patients with AS who admitted to Tokat Gaziosmanpaşa University Internal Medicine and Rehabilitation Outpatient Clinics between 2010 and 2019 were analyzed retrospectively. Demographic characteristics, HLA B27 positivity and detailed eye consultation notes of the patients were recorded. Results: Of the 95 patients, 65 (68%) were male and 30 (32%) were female. The mean age of the patients was 38.3 ± 11.6 years. The HLA B27 results of 10 patients could not be reached. 22% of the patients had at least one episode of uveitis attack. While 82% (70/85) of patients had HLA B27 positivity, this rate was 86% in (18/21) patients with uveitis. Conclusion: Uveitis is a disease that can cause permanent loss of vision. In our study, no significant difference was found between the presence of uveitis and the presence of HLA B27 in patients with AS and this finding needs to be supported by randomized studies.

🔖

Cite This Article

DEMİR, A. K., DEVECİ, H., DEMİR, S. (2019). Frequency of uveitis and its associations with HLA B27 in ankylosing spondylitis patients. Experimental Biomedical Research, Cilt: 2 - Sayı: 4, 132–135. https://ajindex.com/articles/159502

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Gouveia EB, Elmann D, Morales MS. Ankylosing spondylitis and uveitis: overview. Rev Bras Reumatol. 2012; 52(5): 742-56
  2. Sungur G, Yakin M, Uzman S, Balta O, Orman G, Ornek F. Clinical Features and Prognosis of Uveitis in a Turkish Patient Population with Ankylosing Spondylitis: Incidence and Management of Ocular Complications. Ocul Immunol Inflamm. 2019;27(4):551-59
  3. Osenbaum JT. Uveitis in spondyloarthritis including psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease. Clin Rheumatol. 2015; 34(6): 999- 1002
  4. Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984; 27(4): 361-68
  5. Qi J, Li Q, Lin Z, Liao Z, Wei Q, Cao S, et al. Higher risk of uveitis and dactylitis and older age of onset among ankylosing spondylitis patients with HLA-B*2705 than patients with HLA-B*2704 in the Chinese population. Tissue Antigens. 2013; 82(6): 380-86
  6. Laurence M, Asquith M, Rosenbaum JT. Spondyloarthritis, Acute Anterior Uveitis, and Fungi: Updating the Catterall-King Hypothesis. Front Med (Lausanne). 2018;5;5:80
  7. Gueudry J, Muraine M. Anterior uveitis. J Fr Ophtalmol. 2018;41(2):170-182
  8. Robinson PC, Leo PJ, Pointon JJ, Harris J, Cremin K, Bradbury LA, et al. The genetic associations of acute anterior uveitis and their overlap with the genetics of ankylosing spondylitis. Genes Immun. 2016; 17(1): 46-51
  9. Lee JH, Choi M, Rim THT, Lee SC, Lee CS. Clinical Characteristics and Prognostic Factors in Ankylosing Spondylitis Associated Uveitis. Ocul Immunol Inflamm. 2019;27(1):64-69
  10. Birnbaum AD, Jiang Y, Vasaiwala R, Tessler HH, Goldstein DA. Bilateral simultaneous-onset nongranulomatous acute anterior uveitis: clinical presentation and etiology. Arch Ophthalmol. 2012; 130(11): 1389-94
  11. Sun L, Wu R, Xue Q, Wang F, Lu P. Risk factors of uveitis in ankylosing spondylitis: An observational study. Medicine (Baltimore). 2016;95(28):e4233
  12. Ur Rehman S, Anand S, Reddy A, Backhouse OC, Mohamed M, Mahomed I, Atkins AD, James T. Poststreptococcal syndrome uveitis: a descriptive case series and literature review. Ophthalmology. 2006; 113(4): 701-6
  13. Valls Pascual E, Fontanilla Ortega P, Vicens Bernabeu E, Martínez-Costa L, Blanco Alonso R. Clinical characteristics, treatment and ocular complications of HLA-B27-related anterior uveitis and HLA-B27-non related anterior uveitis. Reumatol Clin. 201