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Journals / Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni / 2026 / Cilt: 16 Sayı: 2

INTERACTION BETWEEN MICROBIOME AND IMMUNE SYSTEM: MECHANISMS OF HOMEOSTASIS AND TOLERANCE

MİKROBİYOM VE BAĞIŞIKLIK SİSTEMİ ARASINDAKİ ETKİLEŞİM: HOMEOSTAZ VE TOLERANS MEKANİZMALARI

Abdoul Bassirou Ouedraogo(KIRIKKALE ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ, MİKROBİYOLOJİ (DR) (VETERİNER))0000-0002-5660-1222
Efsun Melike Çeçen(KIRIKKALE ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK ÖNCESİ BİLİMLERİ BÖLÜMÜ, VETERİNERLİK MİKROBİYOLOJİSİ ANABİLİM DALI)0000-0002-3237-9073
Murat Yıldırım(KIRIKKALE ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ, KLİNİK ÖNCESİ BİLİMLERİ BÖLÜMÜ, VETERİNERLİK MİKROBİYOLOJİSİ ANABİLİM DALI)0000-0002-9576-2280
Pages
53–63
Publication Date
2025-08-31
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review aims to elucidate the role of the microbiome in the development of the immune system, the interaction between the microbiota and the immune system, and host-microbiota tolerance mechanisms.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The microbiome plays a significant role in maintaining health and influencing physiological processes, especially during early life when mucosal surfaces are colonized.
📊
Key Findings & Data:Understanding the underlying mechanisms of interaction between the microbiome and the immune system is essential for developing therapeutic strategies aimed at improving immune health and preventing diseases.
💡
Conclusion & Impact:This review aims to elucidate the role of the microbiome in the development of the immune system, the interaction between the microbiota and the immune system, and host-microbiota tolerance mechanisms.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Bağışıklık sistemi · Homeostaz · İmmün tolerans

Abstract

The microbiome plays a significant role in maintaining health and influencing physiological processes, especially during early life when mucosal surfaces are colonized. Colonization shapes immune responses that continue throughout an individual's life. Recent studies have emphasized the importance of the microbiome beyond digestive health, particularly in the regulation of immune responses. Diverse microbial communities in the gut and other mucosal sites contribute to the development of immune cells and the modulation of immune tolerance, enabling the host to differentiate between harmful pathogens and beneficial microorganisms. Disruptions in this balance can lead to immune dysfunction, resulting in autoimmune diseases and allergies. Understanding the underlying mechanisms of interaction between the microbiome and the immune system is essential for developing therapeutic strategies aimed at improving immune health and preventing diseases. This review aims to elucidate the role of the microbiome in the development of the immune system, the interaction between the microbiota and the immune system, and host-microbiota tolerance mechanisms.

Özet

Mikrobiyom, özellikle mukozal yüzeylerin kolonize olduğu erken yaşam döneminde, sağlığın korunmasında ve fizyolojik süreçlerin etkilenmesinde önemli bir rol oynar. Kolonizasyon, bireyin yaşamı boyunca devam eden bağışıklık tepkilerini şekillendirir. Son zamanlarda yapılan çalışmalar, mikrobiyomun sindirim sağlığının ötesinde, özellikle bağışıklık tepkilerinin düzenlenmesindeki önemini vurgulamıştır. Bağırsak ve diğer mukozal bölgelerdeki çeşitli mikrobiyal topluluklar, bağışıklık hücrelerinin gelişimine ve bağışıklık toleransının modülasyonuna katkıda bulunarak konağın zararlı patojenler ile faydalı mikroorganizmalar arasında ayrım yapmasını sağlar. Bu dengedeki bozulmalar, otoimmün hastalıklar ve alerjilerle sonuçlanan bağışıklık fonksiyon bozukluğuna yol açabilir. Mikrobiyom ve bağışıklık sistemi arasındaki etkileşimlerin altında yatan mekanizmaların anlaşılması, bağışıklık sağlığını iyileştirmeyi ve hastalıkları önlemeyi amaçlayan terapötik stratejiler geliştirmek için gereklidir. Bu derleme, mikrobiyomun bağışıklık sisteminin gelişimindeki rolünü, mikrobiyota ve bağışıklık sistemi arasındaki etkileşimi ve konak mikrobiyota tolerans mekanizmalarını ortaya koymayı amaçlamaktadır.

🔖

Cite This Article

Ouedraogo, A. B., Çeçen, E. M., Yıldırım, M. (2025). INTERACTION BETWEEN MICROBIOME AND IMMUNE SYSTEM: MECHANISMS OF HOMEOSTASIS AND TOLERANCE. Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni, Cilt: 16 Sayı: 2, 53–63. https://doi.org/10.38137/vftd.1618052

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