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Journals / Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni / 2026 / Cilt: 17 Sayı: 2026

New Approaches to the Treatment of Osteoarthritis in Horses

ATLARDA OSTEOARTRİT TEDAVİSİNE YENİ YAKLAŞIMLAR

Merve Atasever(HARRAN ÜNİVERSİTESİ, SAĞLIK BİLİMLERİ ENSTİTÜSÜ)0000-0001-9743-1488
Füsun Temamoğulları(Harran University Faculty of Veterinary Medicine Department of Pharmacology and Toxicology)0000-0001-7738-1145
Pages
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Publication Date
2026-06-06
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review compares the advantages and disadvantages of current therapeutic modalities and provides perspectives on the present and future management of OA in horses.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Osteoarthritis (OA) is one of the most common degenerative joint diseases in horses, characterized by the progressive breakdown of cartilage, and represents a leading cause of lameness and loss of performance.
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Key Findings & Data:Conventional treatment strategies, including non-steroidal anti-inflammatory drugs, corticosteroids, and viscosupplementation, are effective in alleviating symptoms but remain limited in halting disease progression.
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Conclusion & Impact:This review compares the advantages and disadvantages of current therapeutic modalities and provides perspectives on the present and future management of OA in horses.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:osteoartrit · tedavi · Horse

Abstract

Osteoarthritis (OA) is one of the most common degenerative joint diseases in horses, characterized by the progressive breakdown of cartilage, and represents a leading cause of lameness and loss of performance. In this review, the pathogenesis, clinical manifestations, diagnostic methods, and therapeutic approaches for equine OA are discussed in light of the current literature. Conventional treatment strategies, including non-steroidal anti-inflammatory drugs, corticosteroids, and viscosupplementation, are effective in alleviating symptoms but remain limited in halting disease progression. In recent years, regenerative therapies have gained prominence. Among these, polysulfated glycosaminoglycans, mesenchymal stem cell therapies, gene therapies, and mitochondrial injections are highlighted as biological approaches with the potential to alter the course of OA. This review compares the advantages and disadvantages of current therapeutic modalities and provides perspectives on the present and future management of OA in horses.

Özet

Osteoartrit (OA), atlarda en sık görülen, kıkırdağın tamamen bozulması ile sonuçlanabilen dejeneratif eklem hastalıklarından biri olup, topallık ve performans kaybının başlıca nedenleri arasında yer alır. Bu derlemede, atlarda OA'nın patogenezi, klinik belirtileri, tanı yöntemleri ve tedavi yaklaşımları güncel literatür doğrultusunda ele alınmıştır. Geleneksel tedavi yöntemleri olan non-steroid antiinflamatuvar ilaçlar, kortikosteroidler ve viskosuplementler, semptomların hafifletilmesinde etkili olmakla birlikte hastalığın ilerleyişini durdurmada sınırlı kalmaktadır. Buna karşılık, son yıllarda rejeneratif tedavi yöntemleri ön plana çıkmıştır. Polisülfatlı glikozaminoglikanlar, mezenkimal kök hücre tedavileri, gen terapileri ve mitokondri enjeksiyonu gibi biyolojik yaklaşımların OA'nın seyrini değiştirme potansiyeli üzerinde durulmaktadır. Derlemede, mevcut tedavi yaklaşımlarının avantaj ve dezavantajları karşılaştırılarak, OA yönetiminde güncel ve geleceğe yönelik perspektifler sunulmuştur.

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Cite This Article

Atasever, M., Temamoğulları, F. (2026). New Approaches to the Treatment of Osteoarthritis in Horses. Veteriner Farmakoloji ve Toksikoloji Derneği Bülteni, Cilt: 17 Sayı: 2026. https://doi.org/10.38137/vftd.1800292

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References (29)

  1. Andersen C, Jacobsen S, Walters M, Lindegaard C. (2022). A detailed macroscopic scoring system for experimental post-traumatic Osteoarthritis in the equine middle carpal joint. BMC Research Notes, 15(1), 226.
  2. Beck AA, Paz LB, Frank MI, Pereira RC, De La Côrte FD. (2025). Lameness improvement in horses with distal tarsal pain after intra-articular injection of botulinum neurotoxin type A. American Journal of Veterinary Research, 1, 1-7.
  3. Cassano JM, Marycz K, Horna M, Nogues MP, Morgan JM et al. (2023). Evaluating the Safety of Intra-Articular Mitotherapy in the Equine Model: A Potential Novel Treatment for Osteoarthritis. Journal of Equine Veterinary Science, 120, 104164.
  4. Christensen L, Camitz L, Illigen K, Hansen M, Sarvaa R, et al. (2016). Synovial incorporation of polyacrylamide hydrogel after injection into normal and osteoarthritic animal joints. Osteoarthr Cartil, 24(11), 1999–2002.
  5. Clarke EJ, Lima C, Anderson JR, Castanheira C, Beckett A, et al. (2022). Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls. Analytical Methods: Advancing Methods and Applications, 14(37), 3661-3670.
  6. Donnell J, Frisbie D. (2014). Use of firocoxib for the treatment of equine osteoarthritis. Vet Med (Auckl), 5, 159-168.
  7. Flood J, Stewart AJ. (2022). Non-Steroidal Anti-Inflammatory Drugs and Associated Toxicities in Horses. Animals: An Open Access Journal from MDPI, 12(21), 2939.
  8. Flood J, Byrne D, Bauquier J, Agne GF, Wise JC, et al. (2023). Right dorsal colitis in horses: A multicenter retrospective study of 35 cases. Journal of Veterinary Internal Medicine, 37(6), 2535-2543.
  9. Frisbie DD, Kawcak CE, McIlwraith CW, Werpy NM. (2009b). Evaluation of polysulfated glycosaminoglycan or sodium hyaluronan administered intra-articularly for treatment of horses with experimentally induced osteoarthritis. American Journal of Veterinary Research, 70(2), 203-209.
  10. Frisbie DD, Kawcak CE, Werpy NM, Park RD, McIlwraith CW. (2007). Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis. American Journal of Veterinary Research, 68(3), 290-296.
  11. Frisbie DD, McIlwraith CW, Kawcak CE, Werpy NM, Pearce GL. (2009a). Evaluation of topically administered diclofenac liposomal cream for treatment of horses with experimentally induced osteoarthritis. American Journal of Veterinary Research, 70(2), 210-215.
  12. Goodrich LR, McIlwraith CW, Grieger J, Kraus VB, Stabler T, et al. (2024). IL-1ra gene therapy in equine osteoarthritis improves physiological, anatomical, and biological outcomes of joint degeneration. Journal of the American Veterinary Medical Association, 262(S1), 109-120.
  13. Hunter DJ, Bierma-Zeinstra S. (2019). Osteoarthritis. Lancet (London, England), 393(10182), 1745-1759. Jacobs CC, Schnabel LV, McIlwraith CW, Blikslager AT (2022). Non-steroidal anti-inflammatory drugs in equine orthopaedics. Equine Vet J, 54(4), 636-648.
  14. Jammes M, Contentin R, Cassé F, Galéra P. (2023). Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies. Frontiers in Veterinary Science, 10, 1115774.
  15. Keegan KG. (2007). Evidence-based lameness detection and quantification. The Veterinary Clinics of North America. Equine Practice, 23(2), 403-423).
  16. Lacitignola L, Imperante A, Staffieri F, De Siena R, De Luca P, et al. (2020). Assessment of Intra- and Inter-observer Measurement Variability in a Radiographic Metacarpophalangeal Joint Osteophytosis Scoring System for the Horse. Veterinary Sciences, 7(2), 39.
  17. Manivong S, Cullier A, Audigié F, Banquy X, Moldovan F, et al. (2023). New trends for osteoarthritis: Biomaterials, models and modeling. Drug Discovery Today, 28(3), 103488.
  18. McIlwraith CW, Frisbie DD, Kawcak CE, Fuller CJ, Hurtig M, et al. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the horse. Osteoarthritis and Cartilage, 18(3), 93-105.
  19. McIlwraith CW, Frisbie DD, Kawcak CE. (2012a). The horse as a model of naturally occurring osteoarthritis. Bone & Joint Research, 1(11), 297-309.
  20. McIlwraith CW, Frisbie DD, Kawcak CE. (2012b). Evaluation of intramuscularly administered sodium pentosan polysulfate for treatment of experimentally induced osteoarthritis in horses. American Journal of Veterinary Research, 73(5), 628-633.
  21. Montero C, Riquelme G, Del Campo M, Lagos N. (2021). Neosaxitoxin, a Paralytic Shellfish Poison phycotoxin, blocks pain and inflammation in equine osteoarthritis. Toxicon: Official Journal of the International Society on Toxinology, 204, 5-8.
  22. Perrone G, Lastra Y, González C, Caggiano N, Giménez R, et al. (2020). Treatment with Platelet Lysate Inhibits Proteases of Synovial Fluid in Equines with Osteoarthritis. Journal of Equine Veterinary Science, 88, 102952.
  23. Reis IL, Lopes B, Sousa P, Sousa AC, Caseiro AR, et al. (2024). Equine Musculoskeletal Pathologies: Clinical Approaches and Therapeutical Perspectives—A Review. Veterinary Sciences, 11(5), 190.
  24. Seabaugh K, Rao S, Koenig JB, Pezzanite L, Dow S, et al. (2024). A Pilot Study to Assess the Safety and Efficacy of Umbilical Cord Blood-Derived Mesenchymal Stromal Cells for the Treatment of Synovitis in Horses. Animals: An Open Access Journal from MDPI, 14(23), 3406.
  25. Smith AD, Morton AJ, Winter MD, Colahan PT, Ghivizzani S, et al. (2016). Magnetic Resonance Imaging Scoring of An Experimental Model of Post-Traumatic Osteoarthritis in the Equine Carpus. Veterinary Radiology & Ultrasound: The Official Journal of The American College of Veterinary Radiology and The International Veterinary Radiology Association, 57(5), 502–514.
  26. Thampi P, Samulski RJ, Grieger JC, Phillips JN, McIlwraith CW, et al. (2022). Gene therapy approaches for equine osteoarthritis. Frontiers in Veterinary Science, 28(9), 962898.
  27. Tischmacher A, Wilford S, Allen K, Mitchell RD, Parkin T, et al. (2022). Retrospective Analysis of the Use of Tiludronate in Equine Practice: Safety on 1804 Horses, Efficacy on 343 Horses. Journal of Equine Veterinary Science, 115, 104007.
  28. Tnibar A. (2022). Intra-articular 2.5% polyacrylamide hydrogel, a new concept in the medication of equine osteoarthritis: A review. Journal of Equine Veterinary Science, 119, 104143.
  29. Van Hecke L, Magri C, Duchateau L, Beerts C, Geburek F, et al. (2021). Repeated intra-articular administration of equine allogeneic peripheral blood-derived mesenchymal stem cells does not induce a cellular and humoral immune response in horses. Veterinary Immunology and Immunopathology, 239, 110306.