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Journals / Experimental Biomedical Research / 2020 / Cilt: 3 - Sayı: 2

Role of uric acid and other parameters in sudden sensorineural hearing loss

Meltem İLANCIOĞLU
Ahmet Turhan URAL
Bengu ÇOBANOĞLU
Asim ÖREM
Pages
99–109
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, we have encountered evidence supporting the possible role of serum uric acid levels in the prognosis of sudden hearing loss.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To investigate the levels of metabolites (predominantly uric acid) effective on biochemical, and coagulation parameters and evaluate their effects on the onset, and course of the disease.
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Key Findings & Data:Methods: In this retrospective study, files of 92 patients hospitalized between January 2007, and December 2013, in our clinic with established diagnosis of sudden hearing loss were screened.
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Conclusion & Impact:However, we have encountered evidence supporting the possible role of serum uric acid levels in the prognosis of sudden hearing loss.
🔬Design:Research Article
📍Scope:2007 Verileri
⚙️Variables:Domain Parameters

Özet

Aim: To investigate the levels of metabolites (predominantly uric acid) effective on biochemical, and coagulation parameters and evaluate their effects on the onset, and course of the disease. Methods: In this retrospective study, files of 92 patients hospitalized between January 2007, and December 2013, in our clinic with established diagnosis of sudden hearing loss were screened. The biochemical (predominantly uric acid), and hematological parameters were compared with those of the control group. In addition, the patient group was divided into two groups according to uric acid levels and the difference between the groups was investigated in terms of the onset or course of the disease. Results: A significant difference was not detected between the patient, and the control groups regarding mean uric acid levels. Among biochemical parameters glucose, creatinine, and international normalized ratio (INR) were significantly higher (p<0.05) while a significant intergroup difference was not detected as for other parameters. A significant intergroup difference was not detected in mean pure- tone averages, and mean hearing gain at admission between two groups formed based on uric acid levels, while post-treatment pure-tone average was significantly better in patients with higher serum uric acid levels. In the patient group, uric acid levels were significantly higher in patients with partial hearing loss relative to those with total loss. Conclusion: In our study, we could not find a significant difference between the patient and the control groups as for uric acid levels. However, we have encountered evidence supporting the possible role of serum uric acid levels in the prognosis of sudden hearing loss.

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Cite This Article

İLANCIOĞLU, M., URAL, A. T., ÇOBANOĞLU, B., ÖREM, A. (2020). Role of uric acid and other parameters in sudden sensorineural hearing loss. Experimental Biomedical Research, Cilt: 3 - Sayı: 2, 99–109. https://ajindex.com/articles/156990

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References (14)

  1. Kuhn M, Heman-Ackah SE, Shaikh JA, et al. Sudden sensorineural hearing loss: a review of diagnosis, treatment, and prognosis. Trends Amplif. 2011
  2. 15(3):91– 105. [2]Byl FM Jr. Sudden hearing loss: eight years' experience and suggested prognostic table. Laryngoscope. 1984
  3. 94(5 Pt 1):647– 61. [3]Kakarlapudi V, Sawyer R, Staecker H. The effect of diabetes on sensorineural hearing loss. Otol Neurotol. 2003
  4. 24(3):382–86. [4]Tavil Y, Kaya MG, Oktar SO, et al. Uric acid level and its association with carotid intima media thickness in patients with hypertension. Atherosclerosis. 2008:197(1):159–16. [5]Alvarez-Lario B, Macarrón-Vicente J. Is there anything good in uric acid? QJM. 2011
  5. 104(12):1015–1024. [6]Siegel LG. The treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Clin North Am. 1975:8(2):467- 73. [7]Colclasure JB, Graham SS. Intracranial aneurysm occurring as sensorineural hearing loss. Otolaryngol Head Neck Surg. 1981
  6. 89(2):283–87. [8]Jaffe BF. Sudden deafness--a local manifestation of systemic disorders: fat emboli, hypercoagulation and infections. Laryngoscope. 1970
  7. 80(5):788– 801. [9]Mattox DE, Lyles CA. Idiopathic sudden sensorineural hearing loss. Am J Otol. 1989
  8. 10(3):242–47. [10]Capaccio P, Ottaviani F, Cuccarini V, et al. Genetic and acquired prothrombotic risk factors and sudden hearing loss. Laryngoscope. 2007
  9. 117(3):547–51. [11]Yasan H, Tüz M, Yariktaş M, et al. The significance of routine laboratory parameters in patients with sudden sensorineural hearing loss. Indian J Otolaryngol Head Neck Surg. 2013
  10. 65(Suppl 3):553–56 [12]Ryu OH, Choi MG, Park CH, et al. Hyperglycemia as a potential prognostic factor of idiopathic sudden sensorineural hearing loss. Otolaryngol Head Neck Surg. 2014
  11. 150(5):853–58. [13]Karli R, Alacam H, Unal R, et al. Mean platelet volume: is it a predictive parameter in the diagnosis of sudden sensorineural hearing loss?. Indian J Otolaryngol Head Neck Surg. 2013
  12. 65(4):350–53. [14]Cadoni G, Agostino S, Scipione S, et al. Sudden sensorineural hearing loss: our experience in diagnosis, treatment, and outcome. J Otolaryngol. 2005
  13. 34(6):395– 401. [15]Waring WS, Webb DJ, Maxwell SR. Effect of local hyperuricemia on endothelial function in the forearm vascular bed. British J Clin Pharmacol. 2000:49(1):511. [16]Kanellis J, Kang DH. Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol. 2005
  14. 25(1):39–42. [17]: Gonick HC, Rubini MD, Gleason IO, et al. Th