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Journals / Experimental Biomedical Research / 2020 / Cilt: 3 - Sayı: 2

A prospective study of serum concentrations of leptin, homocysteine and insulin resistance in children with steroid-sensitive nephrotic syndrome

İpek GÜNEY VARAL
Mahmut CİVİLİBAL
Nilgun SELÇUK DURU
Murat ELEVLİ
Pages
79–89
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Insulin resistance could also develop as a result of steroid use in a short period of time in these patients.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: To measure serum leptin, homocysteine concentrations and insulin resistance in active and remission stages of children with nephrotic syndrome (NS) and to investigate their role in NS pathogenesis.
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Key Findings & Data:Methods: A total of 70 children were included in the study, 40 patients who had been diagnosed with NS and 30 healthy patients were control.
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Conclusion & Impact:Insulin resistance could also develop as a result of steroid use in a short period of time in these patients.
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Aim: To measure serum leptin, homocysteine concentrations and insulin resistance in active and remission stages of children with nephrotic syndrome (NS) and to investigate their role in NS pathogenesis. Methods: A total of 70 children were included in the study, 40 patients who had been diagnosed with NS and 30 healthy patients were control. Changes in plasma concentration of the serum homocysteine, leptin, and insulin were measured and compared with the other parameters in the groups. Results: Serum leptin concentrations in active phase were lower than the remission phase (1.48 ± 0.09 ng/dl, 1.84 ± 1.64 ng/ml, p<0.05). Also, serum homocysteine concentrations in NS group during the active phase were lower than the remission phase and the control group (6.45±2.54 ng/dl, 9.35±2.99 ng/ml, 7.76± 1.97 ng/ml, p<0.05). The serum fasting insulin concentrations and homeostatic model assessment for insulin resistance (HOMA-IR) values of remission phase were significantly higher than those of active phase p<0.05). A positive relationship was found between the homocysteine concentrations and the body mass index of the patient; whereas, a negative relationship was detected between erythrocyte sedimentation rate (ESR), and the LDL-cholesterol concentrations (p<0.05). ESR was found as the only factor associated with lower concentrations of homocysteine during the active phase (r:-0.592, p<0.05). Conclusion: In this study, we demonstrated that serum leptin and homocysteine concentrations decreased in active phase and increased in remission phase in children with NS. Insulin resistance could also develop as a result of steroid use in a short period of time in these patients.

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Cite This Article

VARAL, İ. G., CİVİLİBAL, M., DURU, N. S., ELEVLİ, M. (2020). A prospective study of serum concentrations of leptin, homocysteine and insulin resistance in children with steroid-sensitive nephrotic syndrome. Experimental Biomedical Research, Cilt: 3 - Sayı: 2, 79–89. https://ajindex.com/articles/156989

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