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Journals / Uluborlu Mesleki Bilimler Dergisi / 2026 / Cilt: 9 Sayı: 2026

The Determınant Effect of Novel Inflammatory Markers on Pressure Ulcer Formatıon and Progressıon of Its Stages

Yeni İnflamatuvar Belirteçlerin Basınç Ülseri Oluşumu ve Evrelerinin İlerlemesi Üzerindeki Belirleyici Etkisi

Muhammed Enes Güngör(Banaz 1 nolu Aile Sağlığı Merkezi)0009-0000-0883-3304
Adem Durmaz(Kütahya Sağlık Bilimleri Üniversitesi)0000-0001-5890-3622
Çağla Özdemir(KUTAHYA HEALTH SCIENCES UNIVERSITY)0000-0002-9766-1918
Yasemin Korkut Kurtoğlu(KUTAHYA HEALTH SCIENCES UNIVERSITY)0000-0002-8293-8590
Pages
1–11
Publication Date
2026-09-28
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

It was found that, among the laboratory parameters, elevated CRP levels, elevated neutrophil and platelet counts, and a low MPV were significantly associated with the stage of pressure ulcers.The findings suggest that NLR and PLR may be potentially useful inflammatory markers in predicting ulcer development in patients at risk for pressure ulcers, while MPV may be useful in assessing stage progression in patients with existing pressure ulcers.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this retrospective case-control study, the relationship between new inflammatory markers and the development and stage progression of pressure ulcers (PUs) was evaluated in 1246 patients followed up for pressure ulcers.
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Key Findings & Data:A significant correlation was found between pressure ulcer development and age, immobility, and immobilization duration; in addition, high CRP, low hemoglobin, high neutrophil count, and high NLR and PLR values were found to be associated with pressure ulcer development.
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Conclusion & Impact:It was found that, among the laboratory parameters, elevated CRP levels, elevated neutrophil and platelet counts, and a low MPV were significantly associated with the stage of pressure ulcers.The findings suggest that NLR and PLR may be potentially useful inflammatory markers in predicting ulcer development in patients at risk for pressure ulcers, while MPV may be useful in assessing stage progression in patients with existing pressure ulcers.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Basınç ülseri · immobilite · MPV

Abstract

In this retrospective case-control study, the relationship between new inflammatory markers and the development and stage progression of pressure ulcers (PUs) was evaluated in 1246 patients followed up for pressure ulcers. Participants' sociodemographic characteristics, presence and stages of pressure ulcers, and neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and mean platelet volume (MPV) levels were examined. A significant correlation was found between pressure ulcer development and age, immobility, and immobilization duration; in addition, high CRP, low hemoglobin, high neutrophil count, and high NLR and PLR values were found to be associated with pressure ulcer development. A significant relationship was found between the stage of pressure ulcer and a body mass index above 30, immobility, and duration of immobility. It was found that, among the laboratory parameters, elevated CRP levels, elevated neutrophil and platelet counts, and a low MPV were significantly associated with the stage of pressure ulcers.The findings suggest that NLR and PLR may be potentially useful inflammatory markers in predicting ulcer development in patients at risk for pressure ulcers, while MPV may be useful in assessing stage progression in patients with existing pressure ulcers.

Özet

Bu retrospektif vaka kontrol çalışmasında, basınç ülseri (BÜ) nedeniyle takip edilen 1246 hastada yeni inflamatuar belirteçler ile basınç ülseri gelişimi ve evre progresyonu arasındaki ilişki değerlendirildi. Katılımcıların sosyodemografik özellikleri, basınç ülseri varlığı ve evreleri ile nötrofil/lenfosit oranı (NLR), trombosit/lenfosit oranı (PLR) ve ortalama trombosit hacmi (MPV) düzeyleri incelendi. Basınç ülseri gelişimi ile yaş, hareketsizlik ve immobilizasyon süresi arasında anlamlı korelasyon saptandı; ayrıca yüksek CRP, düşük hemoglobin, yüksek nötrofil sayısı ile yüksek NLR ve PLR değerlerinin basınç ülseri gelişimiyle ilişkili olduğu görüldü. Basınç ülseri evresi ile vücut kitle indeksinin 30’un üzerinde olması, hareketsizlik ve hareketsiz kalma süresi arasında anlamlı ilişki bulundu. Laboratuvar parametrelerinden CRP yüksekliği, nötrofil ve trombosit yüksekliği ile MPV düşüklüğünün basınç ülseri evresi ile anlamlı bir ilişki gösterdiği belirlendi. Bulgular, NLR ve PLR’nin basınç ülseri riski taşıyan hastalarda ülser gelişimini öngörmede, MPV’nin ise basınç ülseri mevcut hastalarda evre progresyonunu değerlendirmede potansiyel olarak yararlı inflamatuar belirteçler olabileceğini düşündürmektedir.

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Cite This Article

Güngör, M. E., Durmaz, A., Özdemir, Ç., Kurtoğlu, Y. K. (2026). The Determınant Effect of Novel Inflammatory Markers on Pressure Ulcer Formatıon and Progressıon of Its Stages. Uluborlu Mesleki Bilimler Dergisi, Cilt: 9 Sayı: 2026, 1–11. https://doi.org/10.71445/umbd.1899067

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