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Journals / International Journal of Medical Biochemistry / 2020 / Cilt: 3 - Sayı: 1

The relationship between homocysteine and autoimmune subclinical hypothyroidism

Mehmet BOLAL
Ihsan ATEŞ
Burak Furkan DEMİR
Mustafa ALTAY
Turan TURHAN
Nisbet YILMAZ
Pages
1–7
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our results indicated that homocysteine was associated with subclinical hypothyroidism.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Homocysteine, an atherosclerotic marker, is thought to be associated with chronic inflammation and autoimmunity.
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Key Findings & Data:Methods: A total of 100 cases, 50 patients who were older than 18 years of age and diagnosed with subclinical hypothyroidism due to Hashimoto’s thyroiditis and 50 controls with no known disease, were included in the study.
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Conclusion & Impact:Our results indicated that homocysteine was associated with subclinical hypothyroidism.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: Homocysteine, an atherosclerotic marker, is thought to be associated with chronic inflammation and autoimmunity. The aim of this study was to investigate the association between the homocysteine level, lipid parameters, high-sensitivity C-reactive protein (hs-CRP), and autoantibodies in subclinical hypothyroid patients. Methods: A total of 100 cases, 50 patients who were older than 18 years of age and diagnosed with subclinical hypothyroidism due to Hashimoto’s thyroiditis and 50 controls with no known disease, were included in the study. Results: Homocysteine (9.6 μmol/L vs 5.5 μmol/L; p<0.001), hs-CRP (2.4 mg/L vs 0.9 mg/L; p<0.001), and low-density lipoprotein-cholesterol levels (115.9±32.7 mg/dL vs 100.3±23.9 mg/dL) (p=0.008) were determined to be higher in the subclinical hypothyroidism group, and the high-density lipoprotein (HDL) cholesterol level (51.2±12.7 mg/dL vs 58.8±15.2 mg/dL; p=0.008) was lower in the subclinical hypothyroidism group compared with the healthy control group. A positive correlation was determined between the homocysteine level and the hs-CRP (r=0.312; p=0.027), anti-thyroid peroxidase (r=0.505; p<0.001), and anti-thyroglobulin (r=0.318; p=0.031) levels in the subclinical hypothyroidism group. Conclusion: In the regression analysis performed, HDL cholesterol, hs-CRP, and homocysteine levels were each found to be an independent risk factor for subclinical hypothyroidism. Our results indicated that homocysteine was associated with subclinical hypothyroidism.

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Cite This Article

BOLAL, M., ATEŞ, I., DEMİR, B. F., ALTAY, M., TURHAN, T., YILMAZ, N. (2020). The relationship between homocysteine and autoimmune subclinical hypothyroidism. International Journal of Medical Biochemistry, Cilt: 3 - Sayı: 1, 1–7. https://ajindex.com/articles/155691

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