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Journals / Turkish Journal of Health Science and Life / 2026 / Cilt: 4 Sayı: 2

EVALUATION OF SERUM LEVELS OF NETRIN-1 AS A POTENTIAL BIOMARKER FOR EARLY PREDICTION OF PREDIABETES

Çiğdem Aydın Acar(BURDUR MEHMET AKİF ERSOY UNIVERSITY)0000-0002-1311-2314
Suray Pehlivanoğlu(NECMETTIN ERBAKAN UNIVERSITY)0000-0001-7422-2974
Mehmet Kök(University of Health Sciences, Antalya Training and Research Hospital)0000-0002-5285-4513
Gizem Yılmaz(NECMETTIN ERBAKAN UNIVERSITY)0000-0001-6183-5771
Pages
70–76
Publication Date
2021-08-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

These results suggested that netrin-1 could be used as a biomarker for the early detection or screening of prediabetes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Prediabetes is a candidate status for Type 2 diabetes, typically identified glycemic values range above normal but below diabetes thresholds.
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Key Findings & Data:Early and accurate diagnosis of this period would be helpful to prevent the diabetes and its consequences.
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Conclusion & Impact:These results suggested that netrin-1 could be used as a biomarker for the early detection or screening of prediabetes.
🔬Design:Araştırma Makalesi
📍Scope:Comprehensive Sample
⚙️Variables:Netrin-1 · Prediabetes · Biomarker

Abstract

Objectives: Prediabetes is a candidate status for Type 2 diabetes, typically identified glycemic values range above normal but below diabetes thresholds. Early and accurate diagnosis of this period would be helpful to prevent the diabetes and its consequences. Netrin-1 is a potential metabolic biomarker that has been associated with diabetes. Previous studies are scarce and have yielded contrasting results on serum netrin-1 levels in diabetes. The aim of this study was to investigate the correlation between serum netrin-1 levels and prediabetes. Methods: Sixty nine participants with prediabetes and 35 healthy controls were included in this study. Serum netrin-1 levels were determined using the Enzyme Linked Immunosorbent Assay (ELISA) method. Correlation analysis were done to assess the relationship between serum netrin-1 levels and biochemical parameters. Results: Serum netrin-1 levels were significantly decreased in the prediabetes group compared to the healthy control group (P<0.0001). A significant negative correlation was observed between serum netrin-1 levels and age, hemoglobin A1c (HbA1c), sedimantation, fasting blood glucose (FBG) and C-reactive protein (CRP) (r = -0.2738, 0.2886, r = -0.3180; P<0.01, r = -0.3439 and r = -0.3987; P<0.01, respectively. Conclusion: Serum netrin-1 significantly negative-correlated with prediabetes and also with FBG and HbA1c. These results suggested that netrin-1 could be used as a biomarker for the early detection or screening of prediabetes.

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Cite This Article

Acar, Ç. A., Pehlivanoğlu, S., Kök, M., Yılmaz, G. (2021). EVALUATION OF SERUM LEVELS OF NETRIN-1 AS A POTENTIAL BIOMARKER FOR EARLY PREDICTION OF PREDIABETES. Turkish Journal of Health Science and Life, Cilt: 4 Sayı: 2, 70–76. https://ajindex.com/articles/1556538

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