SavedAdd your journal

Journals / International Journal of Medical Biochemistry / 2020 / Cilt: 3 - Sayı: 1

The effects of vitamin D and microfracture surgery technique on calcium and phosphorus: A pilot study

Duygu TARHAN
Okan TOK
Denizhan KARİS
Alev Meltem ERCAN
Pages
19–23
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Vitamin D supplementation before microfracture surgery may be beneficial and may prevent a de creased Ca/P ratio due to the effect of surgical stress.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Vitamin D has an important effect on calcium (Ca) and phosphorus (P) metabolism and bone health.
📊
Key Findings & Data:The aim of this study was to investigate the effects of vitamin D and minor surgical stress on Ca and P levels in the liver, kidneys, and serum in 24 New Zealand rabbits with cartilage defects.
💡
Conclusion & Impact:Vitamin D supplementation before microfracture surgery may be beneficial and may prevent a de creased Ca/P ratio due to the effect of surgical stress.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: Vitamin D has an important effect on calcium (Ca) and phosphorus (P) metabolism and bone health. It helps regulate the ratio of Ca and P. The aim of this study was to investigate the effects of vitamin D and minor surgical stress on Ca and P levels in the liver, kidneys, and serum in 24 New Zealand rabbits with cartilage defects. Methods: Experimental groups of MFS (only microfracture surgery), Vit D (only oral vitamin D supplementation), and MFS+Vit D (both microfracture surgery and oral vitamin D supplementation) were created. The levels of Ca and P in serum, liver, and kidney samples were measured using a spectrophotometric method. Results: The kidney Ca/P ratio was lower and the serum Ca/P ratio was higher in the MFS+Vit D groups than in the control group. The serum P level was significantly lower in the MFS and MFS+Vit D groups when compared with the control group. Conclusion: To the best of our knowledge, this is a novel study examining microfracture surgery and the effect on Ca and P. The Ca/P ratio revealed clinically valuable information about the important balance between Ca/P ratio and the adequacy of vitamin D. Vitamin D supplementation before microfracture surgery may be beneficial and may prevent a de creased Ca/P ratio due to the effect of surgical stress.

🔖

Cite This Article

TARHAN, D., TOK, O., KARİS, D., ERCAN, A. M. (2020). The effects of vitamin D and microfracture surgery technique on calcium and phosphorus: A pilot study. International Journal of Medical Biochemistry, Cilt: 3 - Sayı: 1, 19–23. https://ajindex.com/articles/155507

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Grande DA, Schwartz JA, Brandel E, Chahine NO, Sgaglione N. Articular cartilage repair: where we have been, where we are now, and where we are headed. Cartilage 2013;4:281–5
  2. Alford JW, BJ Cole BJ. Cartilage restoration, part I: basic science, historical perspective, patient evaluation and treatment options. Am J Sports Med 2005;33:295–306
  3. Buckwalter JA, Mankin HJ. Articular cartilage, part 1: tissue design and chondrocyte-matrix interaction. Instr Course Lect 1998;47:477–86
  4. Luo Y, Sinkeviciute D, He Y, Karsdal M, Henrotin Y, Mobasheri A, et al. The minor collagens in articular cartilage. Protein Cell 2017;8:560–72
  5. Poole AR, Kojima T, Yasuda T, Mwale F, Kobayashi M, Laverty S. Composition and structure of articular cartilage: a template for tissue repair. Clin Orthop Relat Res 2001;S26–33
  6. Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 2002;10:432–63
  7. O'Driscoll SW. Current concepts review-the healing and regeneration of articular cartilage. J Bone Joint Surg Am 1998;80:1795–812
  8. Bedi A, Feeley BT, Williams RJ 3rd. Management of articular cartilage defects of the knee. J Bone Joint Surg Am 2010;92:994– 1009
  9. Iglar PJ, Hogan KJ. Vitamin D status and surgical outcomes: a systematic review. Patient Saf Surg 2015;9:14
  10. Calışkan Ozcelik D, Kocer H, Kasım I, Sencan I, Kahveci R, Ozkara A. Vitamin D. Turk Med J 2012;6:61–7
  11. Yavuz D, Mete T, Yavuz R, Altunoglu A. Vitamin D, calcium & mineral metabolism, extraskeletal effects of vitamin D and the use of nutritional vitamin d in chronic kidney disease. Ankara Med J 2014;14:162–71
  12. Goretti Pinedo M, Alon US. Phosphate homeostasis and its role in bone health. Pediatr Nephrol 2017;32:1999
  13. Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper’s illustrated biochemistry. 26th ed. New York: McGraw-Hill Companies; 2001
  14. Brown FH. Diet and husbandry. Textbook of rabbit medicine. 3rd ed. Oxford: Butterworth-Heinemann, Elsevier Health Sciences; 2002
  15. Tetlow LC, Woolley DE. Expression of vitamin D receptors and matrix metalloproteinases in osteoarhritic cartilage and human articular chondrocytes in vitro. Osteoarthritis Cartilage 2001;9:423–31
  16. Castillo EC, Hernandez-Cueto MA, Vega-Lopez MA, Lavalle C, Kouri JB, Ortiz-Navarrete V. Effects of Vitamin D supplementation during the induction and progression of osteoarthritis in a rat model. Evid Based Complement Alternat Med