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Journals / The Eurasia Proceedings of Science Technology Engineering and Mathematics / 2026 / Issue: 2

Antioxidant and Antimicrobial Activities of Some Newly Synthesized 4-[1- (2,6-Dimethylmorpholin-4-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-1H-1,2,4- triazol-5-on-4-yl-azomethine]-2-methoxyphenyl benzoates

Yonca Yilmaz
Ahmet Harmankaya
Sevda Manap
Haydar Yuksek
Ozlem Gursoy Kol
Muzaffer Alkan
Pages
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Publication Date
2018-08-19
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The new compounds were examined in-vitro antimicrobial properties against 6 different microorganisms ( Bacillus substilis (ATCC11774) , BacilluscCereus (ATCC11778) , Staphylococcus aureus (ATCC6538), Escherichia coli (ATCC25922) , Pseudomonas aeruginosa (ATCC27853) and Klebsiella pneumonia (ATCC4352)) by the agar well method and the obtained results were evaluated.

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, 4-(3-alkyl/aryl-4,5-dihydro-1 H -1,2,4-triazol-5-one-4-yl-azomethine)-2-methoxyphenyl benzoates were treated with 2,6-dimethylmorpholine in the presence of formaldehyde according to the Mannich reaction to synthesize six novel 4-[1-(2,6-dimethylmorpholin-4-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-triazol-5-on-4-yl-azomethine]-2-methoxyphenyl benzoates.
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Key Findings & Data:The structures of synthesized six novel heterocyclic compounds were characterized by IR, 13 C-NMR and 1 H-NMR spectroscopic methods.
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Conclusion & Impact:The new compounds were examined in-vitro antimicrobial properties against 6 different microorganisms ( Bacillus substilis (ATCC11774) , BacilluscCereus (ATCC11778) , Staphylococcus aureus (ATCC6538), Escherichia coli (ATCC25922) , Pseudomonas aeruginosa (ATCC27853) and Klebsiella pneumonia (ATCC4352)) by the agar well method and the obtained results were evaluated.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Mannich base · 5-dihydro-1H-1 · 4-triazol-5-one

Abstract

In this study, 4-(3-alkyl/aryl-4,5-dihydro-1 H -1,2,4-triazol-5-one-4-yl-azomethine)-2-methoxyphenyl benzoates were treated with 2,6-dimethylmorpholine in the presence of formaldehyde according to the Mannich reaction to synthesize six novel 4-[1-(2,6-dimethylmorpholin-4-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-triazol-5-on-4-yl-azomethine]-2-methoxyphenyl benzoates. The structures of synthesized six novel heterocyclic compounds were characterized by IR, 13 C-NMR and 1 H-NMR spectroscopic methods. The novel 4-[1-(2,6-dimethylmorpholin-4-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-triazol-5-on-4-yl-azomethine]-2-methoxyphenyl benzoates were investigated in vitro antioxidant properties by using reducing power, free radical scavenging and metal chelating activity. For the measurement of the reductive ability, Fe 3+ -Fe 2+ transformation was investigated in the presence of compound using by the method of Oyaizu (1986). The hydrogen atoms or electrons donation ability of the synthesized compound was measured by DPPH . using the method of Blois (1958 ). The chelating effect of ferrous ions by the compound was determined according to the method of Dinis, Madeira & Almeida (1994 ). BHT, BHA, EDTA and α-tocopherol were used as reference antioxidant compounds. The new compounds were examined in-vitro antimicrobial properties against 6 different microorganisms ( Bacillus substilis (ATCC11774) , BacilluscCereus (ATCC11778) , Staphylococcus aureus (ATCC6538), Escherichia coli (ATCC25922) , Pseudomonas aeruginosa (ATCC27853) and Klebsiella pneumonia (ATCC4352)) by the agar well method and the obtained results were evaluated.

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Cite This Article

Yilmaz, Y., Harmankaya, A., Manap, S., Yuksek, H., Kol, O. G., Alkan, M. (2018). Antioxidant and Antimicrobial Activities of Some Newly Synthesized 4-[1- (2,6-Dimethylmorpholin-4-yl-methyl)-3-alkyl(aryl)-4,5-dihydro-1H-1,2,4- triazol-5-on-4-yl-azomethine]-2-methoxyphenyl benzoates. The Eurasia Proceedings of Science Technology Engineering and Mathematics, Issue: 2. https://ajindex.com/articles/1551569

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