Journals / ENT Updates / 2016 / Cilt: 6 - Sayı: 1

Efervesan tabletler: İlaç kullanımı için güvenli vepratik bir uygulama sistemi

Effervescent tablets: a safe and practical delivery system for drug administration

Pages
46–50
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review defines effervescent tablets in terms of thetechnology and describes the advantages and disadvantages.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Effervescence is defined as the evolution of gas bubbles from a liquid as aresult of a chemical reaction.
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Key Findings & Data:Effervescent tablets are used to simplify the handling of doses,provide optimal compatibility, promote superior and rapid absorption,increase a patient's liquid intake and circumvent the difficulty of swallowing large pills.
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Conclusion & Impact:This review defines effervescent tablets in terms of thetechnology and describes the advantages and disadvantages.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Effervescence is defined as the evolution of gas bubbles from a liquid as aresult of a chemical reaction. For medicinal use, effervescent tablets havespecific characteristics that allow rapid adsorption of the intended drug.In this manner, a medication can be absorbed easily and effectively if itdissolves easily in water and is present at a sufficient dose. Common acidsutilized for effervescent reactions are citric, malic, tartaric, adipic andfumaric acids. Citric acid is most commonly used for this application,which also adds a citrus-like taste to the products. Tartaric, adipic andfumaric acids are usually used in small amounts, due to their low watersolubility. Effervescent tablets are used to simplify the handling of doses,provide optimal compatibility, promote superior and rapid absorption,increase a patient's liquid intake and circumvent the difficulty of swallowing large pills. This review defines effervescent tablets in terms of thetechnology and describes the advantages and disadvantages.

Özet

Efervesans, bir sıvı içinde oluflan kimyasal reaksiyon sonucu, çözünme ve gaz kabarcıklarının oluflması olarak tarif edilmektedir. Tıbbi kullanımda efervesan tabletler, verilen ilacın hızlı emilimini sa¤lamaya yönelik bir özellik taflımaktadır. Verilen ilaç, e¤er su içinde yeterli dozda ve kolayca çözünürse daha hızlı ve etkin flekilde emilim sa¤lanacaktır. Kö- pürme reaksiyonu için genellikle sitrik, malik, tartarik, adipik veya fumarik asitler kullanılmaktadır. En sık tercih edilen, ürüne hafif bir limon aroması da veren sitrik asittir. Tartarik, adipik ve fumarik asitler, suda çözünürlükleri daha düflük oldu¤u için daha az miktarlarda kullanılırlar. Uygun ilaç dozu alımının sa¤lanması, ilaca uyumun kolaylafltı- rılması, hızlı ve daha iyi emilim, hastanın sıvı alımının artırılması ve bü- yük tabletlerin yutulma zorlu¤unun ortadan kaldırılması için efervesan tabletler kullanılmaktadır. Bu derlemede, teknolojik açıdan efervesan tabletler de¤erlendirilmifl, avantaj ve dezavantajları tanımlanmıfltır.

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Cite This Article

İPÇİ, K., ÖKTEMER, T., BİRDANE, L., ALTINTOPRAK, N., MULUK, N. B., PASSALI, D., LOPATİN, A., BELLUSSI, L., MLADİNA, R., PAWANKAR, R., CİNGİ, C. (2016). Efervesan tabletler: İlaç kullanımı için güvenli vepratik bir uygulama sistemi. ENT Updates, Cilt: 6 - Sayı: 1, 46–50. https://ajindex.com/articles/154574

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References (18)

  1. Rajlakshmi G, Vamsi C, Balchandar R, Damodharan N. Formulation and evaluation of effervescent tablets of diclofenac potassium. International Journal of Pharmaceutical and Biomedical Research 2011;2;237-43
  2. Mohrle R. Effervescent tablets. In: Liberman HA, Lachman L. Schwartz JB, editors. pharmaceutical dosage form-tablets. Vol. I. First Indian reprint. New York, NY: Marcel Dekker Inc.; 2005. p. 285-92
  3. Stahl H. Effervescent dosage manufacturing. Pharmaceutical Technology Europe 2003;15:25-8
  4. Swarbrick J, Boylon JC. Encyclopedia of pharmaceutical technology. Vol
  5. New York, NY: Marcel Dekker Inc.; 2002. p. 1037-49
  6. Tekade BW, Jadhao UT, Thakre VM, Bhortake LR. Formulation and evaluation of diclofenac sodium effervescent tablet. Innovations in Pharmaceuticals and Pharmacotherapy 2014;2:350-8
  7. Prabhakar CH, Krishna KB. A review on effervescent tablet. International Journal of Pharmacy and Technology 2011;3:704-12
  8. Sweetman SC. Martindle: the complete drug reference. 35th ed. London: Pharmaceutical Press; 2007
  9. Aslani A, Fattahi F. Formulation, characterization and physicochemical evaluation of potassium citrate effervescent tablets. Adv Pharm Bull 2013;3:217-25
  10. Pham JH. Understanding effervescent tableting technology [cited 2015 Nov 29]. Available from:.
  11. Tian XF, Bian BL. Development of effervescent tablet of Chinese traditional medicine and its technology study. [Article in Chinese] Zhongguo Zhong Yao Za Zhi 2004;29:624-7
  12. Lachman L, Liberman HA, Kanig JL. The theory and practice of industrial pharmacy. 3rd ed. Philadelphia, PA: Lea and Febiger; 1986
  13. Allen LV, Popovich NG, Ansel HC. Ansel's pharmaceutical dosage forms and drug delivery systems. 8th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2010
  14. Swarbrick J, Boylan JC. Encyclopedia of pharmaceutical technology. New York, NY: Marcel Dekker; 2002
  15. Altomare E, Vendemiale G, Benvenuti C, Andreatta P. Bioavailability of a new effervescent tablet of ibuprofen in healthy volunteers. Eur J Clin Pharmacol 1997;52:505-6
  16. Monrle R. Effervescent tablet. In: Liberman HA, Lachman I, Schwartz J, editors. Pharmaceutical dosage form: tablets. 2nd ed. New York, NY: Marcel Dekker Inc; 1980
  17. Callahan JC, Cleary GW, Elefant M, Kaplan G, Kensler T, Nash RA. Equilibrium moisture content of pharmaceutical excipients. Drug Dev Ind Pharm 1982;8:355-69
  18. Saleh