SavedAdd your journal

Journals / Ege Üniversitesi Diş Hekimliği Fakültesi / 2017 / Cilt: 38 - Sayı: 1

Drug-induced Gingival Enlargement and Treatment Modalities

İlaca Bağlı Dişeti Büyümeleri ve Tedavi Yaklaşımları

ALİ ÇEKİCİ
ÜLKÜ BAŞER
Hikmet Gamsız IŞIK
DENİZ GÖKÇE ERBİL
FUNDA YALÇIN
AYŞEN GÜLDEN IŞIK
Pages
1–6
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This article is about the prevalence, risk factors, pathogenesis, and clinical management of drug-induced gingival enlargement.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Anticonvulsants, calcium channel blockers and immunosuppressants are the main drug groups that may lead to gingival enlargement.
📊
Key Findings & Data:Although the underlying mechanism of drug-induced gingival enlargement is uncertain, it has been reported several factors such as age, genetics and pharmacokinetic properties of the drugs can play role in pathogenesis of gingival enlargement.
💡
Conclusion & Impact:This article is about the prevalence, risk factors, pathogenesis, and clinical management of drug-induced gingival enlargement.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Anticonvulsants, calcium channel blockers and immunosuppressants are the main drug groups that may lead to gingival enlargement. Although the underlying mechanism of drug-induced gingival enlargement is uncertain, it has been reported several factors such as age, genetics and pharmacokinetic properties of the drugs can play role in pathogenesis of gingival enlargement. The effect of drug on gingiva can vary depending on the genetic characteristics of individuals. This article is about the prevalence, risk factors, pathogenesis, and clinical management of drug-induced gingival enlargement.

Özet

Antikonvülsanlar, kalsiyum kanal blokerleri ve immünosupresanlar dişeti büyümesine neden olan temel ilaç gruplarındandır. İlaca bağlı dişeti büyümelerinin nasıl meydana geldiği tam olarak bilinmese de yaş, genetik ve ilaçların farmakokinetik özellikleri gibi birçok faktörün dişeti büyümesi patogenezinde rol oynayabildiği bildirilmiştir. Bireyin genetik özelliklerine bağlı olarak, ilacın dişeti üzerine etkisi değişebilmektedir. Bu makale, ilaca bağlı dişeti büyümelerinin prevalansı, risk faktörleri, patogenezi ve tedavi yöntemleri ile ilgili bir derlemedir.

🔖

Cite This Article

ÇEKİCİ, A., BAŞER, Ü., IŞIK, H. G., ERBİL, D. G., YALÇIN, F., IŞIK, A. G. (2017). Drug-induced Gingival Enlargement and Treatment Modalities. Ege Üniversitesi Diş Hekimliği Fakültesi, Cilt: 38 - Sayı: 1, 1–6. https://ajindex.com/articles/154287

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (17)

  1. Goncalves SC, Diaz-Serrano KV, de Queiroz AM, Palioto DB, Faria G. Gingival overgrowth in a renal transplant recipient using cyclosporine A. J Dent Child (Chic) 2008;75(3):313-7
  2. Carranza FAH, E.L. Gingival Enlargement. In: Newman GMT, H.H.; Klokkevold, P.R.; Carranza, F.A., editor. Clinical Periodontology. 11 ed. St. Louis, Missouri: Elsevier Saunders, 2012:84-96
  3. Lederman D, Lumerman H, Reuben S, Freedman PD. Gingival hyperplasia associated with nifedipine therapy. Report of a case. Oral Surg Oral Med Oral Pathol 1984;57(6):620-2
  4. Seymour RA, Smith DG, Rogers SR. The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients. A longitudinal study. J Clin Periodontol 1987;14(10):610-3
  5. Marshall RI, Bartold PM. Medication induced gingival overgrowth. Oral Dis 1998;4(2):130-51
  6. Ayanoglou CM, Lesty C. Cyclosporin A-induced gingival overgrowth in the rat: a histological, ultrastructural and histomorphometric evaluation. J Periodontal Res 1999;34(1):7-15
  7. Casamassimo PS. Relationships between oral and systemic health. Pediatr Clin North Am 2000;47(5):1149-57
  8. Kimball O. Treatment of epilepsy with sodium diphenylhydantoinate. J Am Dent Assoc 1939;112:2
  9. Seymour RA, Ellis JS, Thomason JM. Risk factors for drug-induced gingival overgrowth. J Clin Periodontol 2000;27(4):217-23
  10. Dongari-Bagtzoglou A. Drug-associated gingival enlargement. J Periodontol 2004;75(10):1424-31
  11. Seymour RA, Heasman PA. Drugs and the periodontium. J Clin Periodontol 1988;15(1):1-16
  12. Marshall RI, Bartold PM. A clinical review of drug-induced gingival overgrowths. Aust Dent J 1999;44(4):219-32
  13. Kayaalp OS. İmmün Sistem Bozuklukları ve İmmünomodülatör İlaçlar. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. 11 ed: HacettepeTaş Yayınevi, 2005
  14. Ramos ET, NL.; Ravenscraft, MD. Clinical Aspects of Renal Transplantation. In: Brenner BR, FC., editor. The Kidney. 4 ed. Philadelphia, PA: WB Saunders, 1991:2361-407
  15. Kahan BD. Individualization of cyclosporine therapy using pharmacokinetic and pharmacodynamic parameters. Transplantation 1985;40(5):457-76
  16. Rateitschak-Pluss EM, Hefti A, Lortscher R, Thiel G. Initial observation that cyclosporin-A induces gingival enlargement in man. J Clin Periodontol 1983;10(3):237-46
  17. Thomason JM, Seymour RA, Ellis JS, Kelly PJ, Parry G, Dark J, et al. Determinants of gingival overgrowth severity in organ transplant patients. An examination of the role of HL